Vascular Part 1 Flashcards

1
Q

State five reasons why a thrombus does not normally form in intact vessels.

A
  • Smooth surface
  • Prostacyclin
  • heparan sulfate
  • tissue factor pathway inhibitor (TFPI)
  • Thrombomodulin
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2
Q

Platelete activation inhibitor

A

Prostacyclin

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3
Q

Activates antithrombin

A

Heparan sulfate

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4
Q

Inactivates VIIa…controls TF/extrinsic pathway

A

TFPI- Tissue factor pathway inhibitor

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5
Q

Activates protein C pathway

A

Thrombomodulin

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6
Q

State four procoagulant properties of the vascular intima that lend to thrombus formation during vascular damage.

A
  • Vasoconstriction
  • Basement membrane exposes collagen
  • von Willebrand factor secreted
  • Tissue factor exposed
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7
Q

Necessary for platelets to adhere to subendothelial collagen in arterioles; (and eventual) platelet aggregation.

A

von Willebrand factor secreted

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8
Q

Activates plasma coagulation system (factor VII)

A

Tissue factor exposed

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9
Q

Discuss thrombopoiesis:

List the four stages of maturation.

A
  • Megakaryoblast
  • promegakaryocyte
  • megakaryocyte
  • platelets (thrombocytes)
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10
Q

Nucleus round; 2-6 nucleoli; chromatin is homogeneous, loosely organized; cystoplasm basophilic

A

Megakaryoblast

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11
Q

Nucleus indented; nucleoli are variable; chromatin is condensed and cytoplasm is basophilic

A

Promegakaryocyte

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12
Q

Nucleus-2-32 lobes (8 lobes are most common); cytoplasm is blue to pink and abundant; granules reddish blue.

A

Megakaryocyte

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13
Q

No nucleus; light blue to colorless cytoplasm; red to violet, abundant granules.

A

Platelet (thrombocytes)

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14
Q

Regulatory mechanism of thrombopoiesis.

A

Growth factor, specifically hormone called thrombopoietin

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15
Q

Sites of platelet production

A

Medullary=BM; extramedullary=lungs

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16
Q

Describe the morphology of a normal platelet when stained with wright’s stain.

A

chromomere aka granulomere; Hyalomere

Outside of platelets is light color and round

17
Q

Name the two pools into which platelets are distributed

A

Circulatory pool (2/3) and splenic pool (1/3)

18
Q

state the average life span of the platelet

A

8-12 days

19
Q

Discuss four platelet functions.

A

Source of PF3
Source of PF4
Maintain vessel integrity
formation of platelet plug

20
Q

Phospholipid found within platelet membrane and is essential reaction site in the cascade.

A

source of PF 3

21
Q

Protein found in platelet’s alpha granules and is capable of neutralizing heparin

A

Source of PF 4

22
Q

What is the job of maintaining vessel integrity in platelet?

A

Platelets adhere to the subendothelial collagen, and fill in the gaps until new endothelial cells grow

23
Q

List four causes of platelet activation caused by traumatic venipuncture and/or shaking of the sodium citrate tube

A

Subsequent release of PF4
PF4 will neutralize heparin in blood sample
falsely shorten APTT
potential for subsequent over anticoagulation of the paitent

24
Q

In the formation of the platelet plug: Is it primary or secondary hemostasis?

A

Primary

25
Q

In the formation of the platelet plug: does it have short or long term effect?

A

Short term effect

26
Q

In the formation of the platelet plug: list two hemostatic systems involved in primary hemostasis?

A

Vascular intimia and Platelets

27
Q

In the formation of the platelet plug: List type of bleeding with disorder of Primary hemostasis?

A

Temporarily arrests bleeding; excessive bruising & mucocutaenouse

28
Q

In the formation of the platelet plug: type of test are used for diagnostic purposes?

A

Platelet tests

29
Q

List the three steps involved in primary hemostasis.

A

Platelet adhesion
Platelet activation
Platelet aggregation

30
Q

Discuss the platelet adhesion.

A
  • Platelets first adhere to collagen
    • GPIb binds platelet to vWF (bridge)
    • GPIb/IX necessary to attach vWF bridge to the subendothelium for platelet adhesion
31
Q

Discuss the platelet activation.

A

Platelets release procoagulant factors and synthesize prostaglandins to activate platelets

32
Q

Discuss the platelet aggregation

A

Fibrinogen bridge and glycoprotein IIB/IIIa complex needed for platelets to attach to one another that is platelet aggregation

33
Q

List three zones of platelet ultrastructure.

A

Peripheral zone
Sol-gel zone
Organelle Zone

34
Q

Functions as receptor and transmitter region as well as it is essential for adhesion and aggregation.

A

Peripheral zone

35
Q

Functions as cytoskeletal/contractile region.

A

Sol gel zone

36
Q

Functions as metabolic/organelle region and has two types of granules.

A

Organelle zone

37
Q

List two types of granules in organelle zone

A

Alpha and Dense bodies

38
Q

Differentiate quantitative vs. qualitative platelet testing.

A

Quantitative tests– number!!
- Platelet count or slide estimate
Qualitative Tests- Function!!
- Bleeding time, platelet function analyzer (PFA-100), platelet aggregation, clot retraction

39
Q

Indicate why EDTA is the anticoagulant of choice when performing electronic platelets counts.

A

It prevents the clumping of platelets