Vascular Part 1 Flashcards
State five reasons why a thrombus does not normally form in intact vessels.
- Smooth surface
- Prostacyclin
- heparan sulfate
- tissue factor pathway inhibitor (TFPI)
- Thrombomodulin
Platelete activation inhibitor
Prostacyclin
Activates antithrombin
Heparan sulfate
Inactivates VIIa…controls TF/extrinsic pathway
TFPI- Tissue factor pathway inhibitor
Activates protein C pathway
Thrombomodulin
State four procoagulant properties of the vascular intima that lend to thrombus formation during vascular damage.
- Vasoconstriction
- Basement membrane exposes collagen
- von Willebrand factor secreted
- Tissue factor exposed
Necessary for platelets to adhere to subendothelial collagen in arterioles; (and eventual) platelet aggregation.
von Willebrand factor secreted
Activates plasma coagulation system (factor VII)
Tissue factor exposed
Discuss thrombopoiesis:
List the four stages of maturation.
- Megakaryoblast
- promegakaryocyte
- megakaryocyte
- platelets (thrombocytes)
Nucleus round; 2-6 nucleoli; chromatin is homogeneous, loosely organized; cystoplasm basophilic
Megakaryoblast
Nucleus indented; nucleoli are variable; chromatin is condensed and cytoplasm is basophilic
Promegakaryocyte
Nucleus-2-32 lobes (8 lobes are most common); cytoplasm is blue to pink and abundant; granules reddish blue.
Megakaryocyte
No nucleus; light blue to colorless cytoplasm; red to violet, abundant granules.
Platelet (thrombocytes)
Regulatory mechanism of thrombopoiesis.
Growth factor, specifically hormone called thrombopoietin
Sites of platelet production
Medullary=BM; extramedullary=lungs