The Fibrinolytic System: DIC Flashcards
What are five substances in which plasmin is capable of digesting?
The fibrinogen group (I, V, VIII, XIII) plus fibrin
What are the five components of the fibrinolytic system?
plasminogen, plasmin, plasminogen activators, plasminogen and plasmin inhibitors, and fibrinogen/fibrin
What is the general mode of action/function of plasminogen activators?
To convert plasminogen to plasmin
What is the primary plasminogen activator and its source of origin?
Tissue Plasminogen Activator (TPA) and is found in the endothelial cells that line the vessels
What is the consequence of a plasminogen activator deficiency?
Thrombosis
What is the general mode of action/function of plasminogen and plasmin inhibitors?
serve as a check on fibrinolysis by forming an irreversible complex with plasminogen or plasmin
What is the primary inhibitor of plasminogen?
Plasminogen Activator Inhibitor 1 (PAI-1)
What is the primary inhibitor of plasmin?
Alpha-2-antiplasmin
What is the consequence of a deficiency in plasminogen?
Thrombosis
What is the consequence of a deficiency in plasmin inhibitors?
bleeding
This is a substrate in which plasmin acts upon and involves hydrolytic digestion of this by plasmin to form soluble degradation products.
Fibrinogen/Fibrin
Plasmin has the ability to degrade both fibrinogen and fibrin into a series of well characterized end products known as _____ and _____ .
FDP and FSP
What are the two Early degradation products?
Fragments X and Y
What kind of clotting do fragments X and Y do when fibrin acts on them?
“Slow Clotting”
What are the two late degradation products?
Fragments D and E
Fragments D and E have an ________ effect and don’t allow fibrin monomers to line up to form loose bonding.
antipolymerization effect
What are the final split products generated from one fibrinogen molecule?
2D and 1E
How are degradation products cleared from the body?
?
This is an intermediate degradation product formed when plasmin acts upon fibrin that was transmitted through the action of XIIIa. It is formed because plasmin cannot degrade the cross-linked covalent bonds between the D domains.
D-Dimer
What is the nomenclature for D-Dimer?
DD or D2E
What is the significance of a positive D-Dimer?
indicates a clot was/is present
What are two synonyms for DIC?
Consumption Coagulopathy and Defibrination Syndrome
What are seven clinical states associated with DIC? (will write on test)
OB “complications”, Trauma, Sepsis, Intravascular hemolysis, Liver Disease, Promyelocytic Leukemia, and burn patients
