The Fibrinolytic System: DIC

Question 0

What are five substances in which plasmin is capable of digesting?

Answer 0

The fibrinogen group (I, V, VIII, XIII) plus fibrin

Question 1

What are the five components of the fibrinolytic system?

Answer 1

plasminogen, plasmin, plasminogen activators, plasminogen and plasmin inhibitors, and fibrinogen/fibrin

Question 2

What is the general mode of action/function of plasminogen activators?

Answer 2

To convert plasminogen to plasmin

Question 3

What is the primary plasminogen activator and its source of origin?

Answer 3

Tissue Plasminogen Activator (TPA) and is found in the endothelial cells that line the vessels

Question 4

What is the consequence of a plasminogen activator deficiency?

Answer 4

Thrombosis

Question 5

What is the general mode of action/function of plasminogen and plasmin inhibitors?

Answer 5

serve as a check on fibrinolysis by forming an irreversible complex with plasminogen or plasmin

Question 6

What is the primary inhibitor of plasminogen?

Answer 6

Plasminogen Activator Inhibitor 1 (PAI-1)

Question 7

What is the primary inhibitor of plasmin?

Answer 7

Alpha-2-antiplasmin

Question 8

What is the consequence of a deficiency in plasminogen?

Answer 8

Thrombosis

Question 9

What is the consequence of a deficiency in plasmin inhibitors?

Answer 9

bleeding

Question 10

This is a substrate in which plasmin acts upon and involves hydrolytic digestion of this by plasmin to form soluble degradation products.

Answer 10

Fibrinogen/Fibrin

Question 11

Plasmin has the ability to degrade both fibrinogen and fibrin into a series of well characterized end products known as _____ and _____ .

Answer 11

FDP and FSP

Question 12

What are the two Early degradation products?

Answer 12

Fragments X and Y

Question 13

What kind of clotting do fragments X and Y do when fibrin acts on them?

Answer 13

“Slow Clotting”

Question 14

What are the two late degradation products?

Answer 14

Fragments D and E

Question 15

Fragments D and E have an ________ effect and don’t allow fibrin monomers to line up to form loose bonding.

Answer 15

antipolymerization effect

Question 16

What are the final split products generated from one fibrinogen molecule?

Answer 16

2D and 1E

Question 17

How are degradation products cleared from the body?

Answer 17

?

Question 18

This is an intermediate degradation product formed when plasmin acts upon fibrin that was transmitted through the action of XIIIa. It is formed because plasmin cannot degrade the cross-linked covalent bonds between the D domains.

Answer 18

D-Dimer

Question 19

What is the nomenclature for D-Dimer?

Answer 19

DD or D2E

Question 20

What is the significance of a positive D-Dimer?

Answer 20

indicates a clot was/is present

Question 21

What are two synonyms for DIC?

Answer 21

Consumption Coagulopathy and Defibrination Syndrome

Question 22

What are seven clinical states associated with DIC? (will write on test)

Answer 22

OB “complications”, Trauma, Sepsis, Intravascular hemolysis, Liver Disease, Promyelocytic Leukemia, and burn patients