The Cascade System (PART 1)

Question 0

What a factor becomes activated, it is referred to as what?

Answer 0

serine protease

Question 1

What are clotting factors that circulate in blood as distinct entities in an inactive form?

Answer 1

zymogens

Question 2

What binds to a particular serine protease to stabilize and increase reactivity?

Answer 2

Cofactors

Question 3

This Factor is a substrate for thrombin and polymerizes to form fibrin.

Answer 3

Factor I-Fibrinogen

Question 4

This factor is a cofactor for II —> IIa and is a part of the prothrombinase complex

Answer 4

Factor V-Labile factor

Question 5

This factor is a cofactor for X –> Xa

Answer 5

VIII:C

Question 6

This factor is a carrier protein for VIII:C and is needed for platelet adhesion to collagen.

Answer 6

vWF

Question 7

This factor is a transglutaminase which converts loose hydrogen bonds of fibrin monomers to covalent bonds.

Answer 7

XIII-Fibrin stabilizing factor

Question 8

This factor is a serine protease and a precursor to thrombin.

Answer 8

Factor II-Prothrombin

Question 9

This factor is a serine protease and activates X and IX (in vivo).

Answer 9

Factor VII-Stabile Factor

Question 10

This factor is a serine protease and with help of the cofactor VIIIa it converts X—>Xa

Answer 10

Factor IX-Christmas Factor

Question 11

This factor is a serine protease that is a part of the prothrombinase complex which converts II—>IIa

Answer 11

Factor X- Stuart Prower Factor

Question 12

This factor is a serine protease that converts IX–>IXa

Answer 12

Factor XI-Plasma Thromboplastin Antecedant

Question 13

This factor is a serine protease (in vivo) that is activated in the presence of HMWK and PK to activate XI–>XIa

Answer 13

Factor XII-Hageman Factor

Question 14

This factor is a serine protease (in vivo) and with the help of cofactor HMWK it activates XI–>XIa

Answer 14

Factor PK- Fletcher Factor

Question 15

This factor is a cofactor that participates in the (in vitro) contact activation of XI–>XIa and activates the Kinin System.

Answer 15

Factor HMWK- Fitzgerald Factor

Question 16

Which factors are synthesized in the liver? (12 of them)

Answer 16

Factors I, V, VIII:C, XIII, II, VII, IX, X, XI, XII, PK, and HMWK

Question 17

Which cofactors are synthesized in the endothelial cells and megakaryocytes?

Answer 17

vWF

Question 18

Which enzyme is generated from the coagulation pathway that is needed to convert fibrinogen to fibrin?

Answer 18

Thrombin*

Question 19

Which site provides the surface for the coagulation cascade?

Answer 19

PF3 (PL)

Question 20

Initiation of coagulation by ______ is sufficient to initiate activation of both pathways.

Answer 20

TF or Factor VII complex