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Oral Path 2 Finals > Vascular Lesions > Flashcards

Vascular Lesions Flashcards

1
Q

Congenital vascular lesions

A

Lymphangioma and hemangioma

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2
Q

Neoplasm vascular lesion

A

Angiosarcoma and kaposi sarcoma

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3
Q

Benign vascular lesion composed of a localized collection of dilated lymphatic channels

A

Lymphangioma

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4
Q

Presents as painless, nodular, vesicle like swellings when superficial or as submucosal masses when located deeper

Diagnosed within the first two decades of life

A

Lymphangioma

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5
Q

Location of intraoral lymphangioma

And extraoral lymphangioma

A

Tongue most common
Palate, buccal mucosa gingiva and lips

Skin and subcutaneous tissues

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6
Q

Lymphangioma of the lip may cause a ____

A

Macrocheilia (permanent swelling of the lip)

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7
Q

A diffuse soft tissue swelling that may be life threatening because it involves vital structures of the neck

A

Lymphangioma of the neck

Aka

Cystic hygroma, hygroma colli or cavernoius lymphangioma

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8
Q

Histopathological feature

Variably sized, irregular, this walled fluid - filled spaces are lined by lymphatic epithelium ad surrounded by a stroma of fibrous, smooth muscle and adipose tissue along with lymphocytes

A

Lymphangioma

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9
Q

Histopathological feature of lymphagioma

A

Variably sized, irregular, this walled fluid - filled spaces are lined by lymphatic epithelium ad surrounded by a stroma of fibrous, smooth muscle and adipose tissue along with lymphocytes

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10
Q

IHC profile of lymphangioma

A

D2-40 (podoplanin, transmembrane mucoprotein)

CD31, SMA on walls of lymphatic vessels

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11
Q

Treatment for lymphangiooma

A

Surgical excision

Recurrence are common die to its non-encapsulated nature

Pwede pd sclerotherapy

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12
Q

Etiology of kaposi sarcoma

A

Human herpersivrus 8

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13
Q

The lesion consists of an unencapsulated proliferation of anaplastic endothelial cells enclosing irregular luminal spaces

A

Angiosarcoma

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14
Q

Benign vasular lesion/ tumor

Abnormal endothelial cell proliferation

A

Hemangioma

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15
Q

Subtype of hemangioma:

Proliferation of capillaries with plump endothelial cells in a fibromyxoid stroma, arranged in lobules

A

Lobullar capillary hemangioma

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16
Q

Subtype of hemangioma

Multiple, large cystic, thin-walled, blood filled spaces lined by endothelial cells and separated by scant connective tissue stroma

A

Cavernous hemangioma

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17
Q

Essential diagnostic criteria

Polypoid, lobular circumscribed nastomosing network of capillaries

Plump endothelial cells

Fibroymxoid stroma arranged in one or more lobules

A

Hemangioma

18
Q

Treatment for hemangioma

A

Excision

45% recurrence, more common in children if not completely eradicated

M,ay regress spontaneously

19
Q

Two vascular malformationt that was introduced in the topi

A

Struge weber syndrome (encephalotrigeminal angiomatosis)

And

Rendu-osler weber syndrome (hereditary hemorrhagic telangiectasia)

20
Q

Malignant neoplasm that represents the morphological and iHC features of endothelial cells and unknown origin

A

Angiosarcoma

21
Q

Usual location or amgiosarcomas

A

Scalp

Occasionally in maxillary sinus and oral cavity

22
Q

Unencapsulated prliferation of anaplastic endothelial cells enclosing irregular luminal spaces

Has an aggressive clinical course and a poor prognosis

A

Angiosarcoma

23
Q

Non specific, general signs and symptoms of enlarging tumor

Invasion of vital structures and bone erosion

5th decade = male

39mm

A

Angiosarcoma

24
Q

Less than 15mm in size __

More than 39mm in size

A

<15 mm hemagioma

39mm > angiosarcoma

25
Q

Histologic features

Anastomosing vascular space line by atypical endothelial cells; infiltrative growth; endothelial multilayering; marked nuclear atypia; brisk mitotic activity

A

Angiosarcoma

26
Q

IHC for angiosarcoma

A

ERG transcription factor - most commonly used
CD34, CD31

27
Q

40% reoccur

60% overall srvival rate

Metastasis spread most commonly to the lungs, liver, spleen and bone

A

Angiosarcoma

28
Q

Also of endothelial origin but known to be caused by the human herpesvirus 8 (HHV8)

A

Kaposi sarcoma

29
Q

Locally agressive vascular endothelial proliferation assciated with HHV-8

Immunocompromised, AIDS related

A

Kaposi sarcoma

30
Q

Multiple reddish to purple macules that progress into plaques or nodules, which may ulcerate

A

Kaposi sarcoma

31
Q

Etiologic agent for kaposi sarcome

A

Herpesvirus
Aids

32
Q

Kaposi sarcoma that is predominntly in older men living in the mediterranean basin

A

Classic type kaposi sarcoma

33
Q

Kaposi sarcoma that apears multifocal reddish brown nodules primarily in the skin of the lower extremities , organ may also be affected

Indolent course and only a fair prognosis

A

Classic type kaposi sarcoma

34
Q

Was identified in africa, where it is considered endemic

Seen in extremities of blacks

Most commonly affected organ is the skin

A

Endemic type of kaposi sarcoma

35
Q

Kaposi sarcoma seen in patients with immunodeficiency status, includes with organ transplants and commonly associated with AIDS

A

Immunodeficiency type of kaposi sarcoma

36
Q

Hypercellular foci containing bland-appearing spindle cells, ill-defined vascular channels and extravasated RBC

A

Kaposi sarcoma

37
Q

IHC for kaposi sarcoma

A

CD31, CD34 and
factor VIII-related antigen will identify endothelial cell derived tumors

38
Q

DD of kaposi

A

Hemangioma
Erythroplakia
Melanoma
Pyogenic granuloma

39
Q

Treatment of kaposi

A

Highly active antiretroviral therapy (HAART)

40
Q

Small, slit like vascular spaces with extravasated RBC

Mildly atypical cell with surrounding bland spindle cells

Lymphocytic infiltrate is present

Unencapsulated infiltrating fascicles of spondle cells with atypia and mitoses

A

Kaposi sarcoma

41
Q

Extraoral; unilateral epixstasis

Oral: solitary, red hemorrhagic papule

A

Hemangioma

Oral Path 2 Finals (9 decks)

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