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Oral Path 2 Finals > Connective Tissue Lesion Neural > Flashcards

Connective Tissue Lesion Neural Flashcards

1
Q

Part of a neuron

Receive signals from other neuron cells

A

Dendrites

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2
Q

Part of a neuron

Contains the cell nucleus

A

Cell body

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3
Q

Part of a neuron

Conducts electrical impulses along the neuron cell

A

Axon

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4
Q

Part of a neuron

Insulates the axon to help protect the neuron cell and speed up transmission of electrical impulses

A

Myelin sheath

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5
Q

Part of a neuron

Transmits electrical and chemical signals to other neuron cells and effector cells

A

Axon terminal

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6
Q

Etiology of traumatic neuromas

A

From tooth extraction, local anesthesia injection, from accident

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7
Q

Most common location of traumatic neuroma

A

Mental foramen

Palate - if soft tissue location

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8
Q

Microscopically, bundles of nerves in a haphazard or tortuous arrangement are found admixed with dense collagenous fibrous tissue

A

Traumatic neuroma

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9
Q

Treatment for traumatic neuroma

A

Surgical excision

No recurrence

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10
Q

Clinical features of traumatic lesion

A

50% cases are associated with pain

Radiating facial pain

Wide age range, mostly seen in adults

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11
Q

Is traumatic neuroma encapsulated?

A

Yes = good prognosis

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12
Q

Benign neoplasm that is derived from a proliferation of Schwann cells of the neurilemma or nerve sheath

A

Schwannoma

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13
Q

Capable of regeneration

Prerequisite for regenrating neurons of the PNS

The nerve is pushed aside (does not entangle within the tumor)

A

Schwannoma (neurilemmoma)

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14
Q

Encapsulated mass, asymptomatic lump in any age

Tongue = favored location

40S% occur in head and neck

A

Schwannoma

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15
Q

Well defined radiolucent pattern with a corticated periphery and may cause pain or pasthesia

A

Schwannoma

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16
Q

Encapsulated tumor, spindle cells with two different pattern. Antoni A and Antoni B

A

Schwannoma

17
Q

IHC immunoprofile of schwannoma

A

S-100

Negative for actin and desmin

18
Q

Consists of spindle cell organized in palisaded whorls and waves

Often surround an acellular eosinophilic zone (verocay body)

Representing reduplicated basement membrane and cytoplasmic cellular processes

A

Antoni A of schwannoma

19
Q

Consists of spindle cells haphazardly distributed in a delicate fibrillar microcystic matrix

A

Antoni B Of schwannoma

20
Q

Hyopercellular
Nuclear palisading
Whorls and waves
Verocay bodies

A

Antoni A

21
Q

Hypocelular
Loosely arranged
Haphazard
Myxoid background

A

Antoni B

22
Q

Essential diagnostic criteria of schwannoma (neurilemmoma)

A

Hypecellular spindled areas and loose hypocellular myxoid bodies

Spindle cells with buckled, elongated, fusiform nuclei, palisaded

S-100, SOX10 positive

23
Q

Treatment for schwannoma

A

Surgical excision

Good prognosis - encapsulated

24
Q

May appear as solitary lesion or as multiple lesions as part of the neurofibromatosis (von recklinghausen’s disease of skin)

A

Neurofibroma

25
Q

An inherited autosomal-dominant trait that has two subsets: one associated with NF1 gene and the other with the NF2 gene

A

Neurfibroma

26
Q

Cell of origin of:

Schwannoma
Neurofibroma
Mucosal neuroma
PEN

A

Schwann cell
Schwann cell and perineural fibroblast
Nerve tissue, hamartoma
Schwann cell

27
Q

Age

Schwannoma
Neurofibroma
Mucosal neuroma
PEN

A

Any
Any
Children, young adults
Adults

28
Q

Site

Schwannoma
Neurofibroma
Mucosal neuroma
PEN

A

Any, especially tongue
Any, especially tongue, buccal mucosa
Tongue, lip, buccal mucosa
Palate, lip

29
Q

Number

Schwannoma
Neurofibroma
Mucosal neuroma
PEN

A

Solitary
Solitary to multiple
Multiple
Solitary

30
Q

Bone lesions

Schwannoma
Neurofibroma
Mucosal neuroma
PEN

A

Occasionally
Frequently
No
No

31
Q

Syndrome associated

Schwannoma
Neurofibroma
Mucosal neuroma
PEN

A

Neurofibromatosis
Neurofibromatosis
MEN III
None

32
Q

Malignant potential

Schwannoma
Neurofibroma
Mucosal neuroma
PEN

A

Rarely with sydrome
Infrequently with syndrome
No
No

33
Q

clinical features of neurofibroma

A

Asymptomatic submucosal mass (neoplastic)

Unencapsulated

Tongue, buccal mucosa and vestibule - most commonly affected

NF1: multiple neurofibroma. Cafe-au-lait, bone abnormalities, CNS changes

34
Q

Histopath

Non-encapsulatd

Random distribution o spindle cells in myxoid to collagenous stroma

Nuclei are wavy and tapered

A

Neurofibroma

35
Q

IHC of neurofibroma

A

S-100, SOX10, CD34

36
Q

Contains the genetic material of the neuron cell

A

Nucleus

Oral Path 2 Finals (3 decks)

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