Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Oral Path 2 Finals > Muscular Lesions > Flashcards

Muscular Lesions Flashcards

1
Q

A muscular reactive lesion

A

Myositis ossificans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Location of myositis ossificans

A

Sternocleidomastoid, masster

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Muscular lesion in neoplasm origin

A

Leiomyoma/leiomyosarcoma

Rhabdomyoma/rhabdomyosarcoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

IHC profile for skeletal lesions

A

+ myogenin , myoglobin , desmin

  • smooth muscle actin , calponin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

IHC profile for smooth muscle lesion

A

+ desmin , smooth muscle actin , calponin

  • myogenin , myoglobin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Location of leiomyoma/sarcoma

A

Non-specific, blood vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Location of rhabdomyoma/sarcoma

A

Floor of the mouth , soft palate , tongue , buccal mucosa , masticatory muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Uncommon reactive lesion of skeletal muscle

A

Myositis ossificans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Myositis ossificans is an ____ inflammatory process in which ossification occurs

A

Intramuscular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Two forms of myositis ossificans

A

Progressive systemic disease ( myositis ossificans progresiva )

Focal single - muscle disorder ( traumatic myositis ossificans )

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Etiology of Progressive systemic disease ( myositis ossificans progresiva )

A

Unknown cause

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Etiology of Focal single - muscle disorder ( traumatic myositis ossificans )

A

Acute or chronic trauma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Most common location of myositis ossificans in the head and neck region

A

Sternocleidomastoid and masseter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Radiographic feature of myositis ossificans

A

Delicate feathery opacification

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Essential diagnostic feature of myositis ossificans

A

Maturation and organization of the osseous tissue peripheral to the central cellular zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Treatment for myositis ossificans

A

Surgical excision

Little tendency to recur

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Most common arise from leiomyosarcoma

A

In the retroperitoneum, mesentery, omentum or subcutaneous and in deep tisues of the limbs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Most common arise of leiomyomas

A

Muscularis layer of the gut and in the body of the uterus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Presents as slow-groing, asymptomatic subucosal masses

Usually in the tongue, hard palate or buccal mucosa

Sinonasal tract, mandible

Any age

A

Leiomyomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Subtype of leiomyoma

A

Angioleiomyoma (vascular leiomyoma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Treatment for leiomyomas

A

Surgically excised, recurrence is unexpected

22
Q

A small cytoplasmic filament, about 5nm in diameter that has contractile properties

A

Actin

23
Q

Treatment for leiomyosarcomas

A

Wide surgical excision + chemo/radio

Distant metastasis to lungs (50%)

24
Q

Clinical features of leiomyoma

A

Soft tissue swelling

1% leiomyoma are located in H&N
- 12-15% are angioleiomyomas

M=F predilection

25
Q

20% 5-year survival rate

A

Leiomyosarcoma

26
Q

50% of case, distant metastasis to lungs

A

Leiomyosarcoma

27
Q

Bland, spindled tumor cells are arranged in intersecting fascicles. Cells are oval to elongated with cigar-shaped nuclei, without atypia. Mitoses are absent to sparse

A

Leiomyoma

28
Q

Histopathological feature of leiomyoma

A

Bland, spindled tumor cells are arranged in intersecting fascicles. Cells are oval to elongated with cigar-shaped nuclei, without atypia. Mitoses are absent to sparse

29
Q

Histopathological features of angioleiomyoma

A

Prominent vasculature surrounded by smooth muscle cells associated with vessels

30
Q

Prominent vasculature surrounded by smooth muscle cells associated with vessels

A

Angioleiomyoma

31
Q

IHC profile for leiomyoma

A

Desmin

HMB45

32
Q

Essential diagnostic rieria of leiomyosarcoma or angioS

A

Fascicles of eosinophilic spindled cells with blunt ended nuclei with variable pleomorphism and mitoses

33
Q

Fascicles of eosinophilic spindled cells with blunt ended nuclei with variable pleomorphism and mitoses

A

Leiomyosarcoma / angiosarcoma

34
Q

Localization of rhabdomyoma

A

Momuth and soft tissues of the neck

Parapharyngeal space, salivary glands, larynx

35
Q

Two types of rhabdomyoma

A

Adult type (ARM)
Fetal typee (FRM)

36
Q

Age and gender predilection for the two types of rhabdomyoma

A

ARM - 60yo , M:F = 3:1

FRM - 4.5-60yo , M:F = 5:1

37
Q

Histopathological features of rhabdomyoma

For ARM and FRM

A

ARM: large polygonal cells having abundant eosinophilic, granular or vacuolated cytoplasm (spider cells) with focal cross striation or crystalline (rod-like or jack straw like) inclusion

FRM: primitive round to spindle cells and myotube-like rhabdomyoblasts with eosinophilic cytoplasm and cross-striations set in a myxoid matrix

38
Q

IHC for rhabdomyoma

A

Myogenin
Desmin
Myoglobin

39
Q

Treatment for rhabdoymyoma

A

Complete excision

No metastasis

40
Q

Subtype of rhabdomyosarcoma thatt occurs in children

A

Embryonal and alveolar

41
Q

Histopathological feature

Primitive round to spindle cells, with scant cytoplasm and hyper chromatic nuclei, scattered rhabdomyoblasts

A

Embryonal rhabdomyosarcoma

42
Q

Histopathological feature

Fibrovascular septa separating cellular nests of small sized monomorphic round cells with scant cytoplasm, rhabdoid

A

Alveolar rhabdomyosarcoma

43
Q

Histopathological feature

Fasciculated proliferation of spindle cells with elongated nuclei and pale indistinct cytoplasm, with interspersed spindled or polygonal rhabdomyoblasts with abundant, brightly eosinophilic cytoplasm

A

Spindle rhabdomyosarcoma

44
Q

Treatment for rhabdomyosarcoma

A

Surgical excision, chemo/radio

Most adult patients are stage IV at presentation

RMS poor prognosis (40-45% 5-year survival rate)

45
Q

Subtype of rhabdomyosarcoma that has an excellent prognosis

A

Spindle ell and botryoid type

46
Q

When it occurs in the head and neck region, it is typically seen in children. When it occurs outside, it is typically seen in adults

A

Rhabdomyosarcoma

47
Q

Rapidly growing mass that may cause pain or paresthesia if jaw involvement ocurs.

A

Rhabdomyosarcoma

48
Q

The most common subtype of rhabdoymyosarcoma

A

Embryonal type

49
Q

IHC for rhabdoymosarcoma

A

Desmin , acting , myogenin , myoD1

50
Q

Two consistent and reproducible chromosome translocation that is associated with alveolar rhabdomyosarcoma

A

T(12:13) (q35;q14)
And
T(1:13)(p36q14) - less common

These translocation juxtapose the PAX3 or PAX7 gene on chromosomes 2 and 1

Oral Path 2 Finals (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions