Vascular Disorder Flashcards
Tendency to bruise easily or bleed spontaneously yields normal platelet and blood coagulation
Vascular disorder
3 Hereditary vascular disorders
Hereditary hemorrhagic telangiectasia
Hemangioma thrombocytopenia syndrome
Ehlers Danlos syndrome
Organisms that causes HUS (Hemolytic Uremic Syndrome)
Shigella dysenteriae
E coli 0157:H7
Hereditary hemorrhagic telangiectasia also known as
Osler-Weber-Rendu disease
Cardinal signs of HUS (Hemolytic Uremic Syndrome)
Hemolytic anemia
Renal failure
Thrombocytopenia
Autosomal dominant resulting in dilated superficial blood vessels, thin walled blood vessel with discontinuous endothelium and inadequate or missing elastin and most common inherited vascular disorder
Hereditary hemorrhagic telangiectasia
Activation of coagulation cascade resulting to consumptive coagulopathy that entraps platelets in the intravascular fibrin clots
Disseminated Intravascular Coagulation (DIC)
3 Other disorder with telangiectasia
Cherry red hemangiomas
Ataxia telangiectasia
Chronic actinic telangiectasia
Type of DIC which is D dimer positive
Acute DIC (Disseminated Intravascular Coagulation)
Telangiectasia in older men and women
Cherry red hemangiomas
Type of DIC may not be detachable or slightly increased, usually causes by another underlying condition
Chronic DIC (Disseminated Intravascular Coagulation)
Telangiectasia associated with louis bar syndrome
Ataxia telangiectasia
3 Big spleen syndromes
Gaucher
Hodgkin
Sarcoidosis
Hemangioma thrombocytopenia syndrome also known as
Kasabach-meritt syndrome
secondary thrombocytosis
below 800,000 plts
moderate increase and asymptomatic
Reactive thrombocytosis
associated with giant cavernous hemangioma, tumor, thrombocytopenia, bleeding diathesis
other features: acute and chronic DIC and microangiopathic hemolytic anemia
Hemangioma-Thrombocytopenia syndrome
Primary thrombocytosis
elevated platelets (more than millions)
markedly increase
Autonomous thrombocytosis
Treatment for HTS (Hemangioma thrombocytopenia syndrome)
corticosteroid therapy and surgery
6 Acquired vascular disorders
- Allergic purpura
- Senile purpura
- Paraproteinemia and amyloidosis
- Drug induced vascular purpura
- Vitamin C deficiency
- Henoch-Schonlein purpura
2 Qualitative disorders of platelets
Bernard-Soulier syndrome
Glanzmann thrombasthenia
Group of nonthrombocytopenic purpura characterized by apparently allergic manifestations. It is associated with certain foods, drugs, cold, insect bites
Allergic purpura
giant platelet syndrome, lack gp Ib/Ix/V, autosomal recessive
Bernard-Soulier syndrome
autoimmune vascular injury, immunologic damage to EC, affecting boys ages 3-7 years of age after respiratory infection, palpable purpura, elevated: WBC and ESR
Henoch-Schonlein Purpura
Drugs that causes drug induced vascular purpura
Aspirin
Warfarin
Barbiturates
Diuretics
Digoxin
Methyldopa
Sulfonamides
Iodides