Coagulation Factors Flashcards
Process by which blood is maintained within the vessel walls
Hemostasis
Platelets adhere to each other
Aggregation
Platelet roll and “cling to non-platelet surfaces”
Adhesion
Primary substrate of thrombin
Fibrinogen
Coagulation factor that stabilizes fibrin clot
Factor XIII
Other name for Factor XIII
Transglutaminase
Required for the assembly of coagulation complexes on platelet or cell membrane phospholipid
Calcium
Glycoprotein receptor for fibrinogen
GP IIb/IIIa
Glycoprotein receptor for Von Willebrand Factor
GP Ib
Induces smooth muscle relaxation and subsequent vasodilation, inhibits platelet activation
Nitric oxide
Controls activation of the tissue factor pathway
Tissue factor pathway inhibitor (TFPI)
Syndrome in which the platelet GP Ib/IX/V receptor is absent
Bernard-Soulier syndrome
Syndrome in which the platelet GP IIb/IIIa receptor is absent
Glanzmann thrombasthenia
transmembrane receptor for factor VIIa
Tissue Factor
Where can you find Tissue Factor?
Fibroblast and Smooth Muscles
Factors V and VIII
Labile Factors
tenase complex that composed of factor Xa and its cofactor Va
Prothrombinase
Storage site of von Willebrand Factor in the endothelium
Weibel-Palade bodies
adhesion molecule that promotes platelets and leukocyte binding
P-selectin
protein that inhibits plasmin generation and fibrinolysis
Plasminogen Activator Inihibitor 1
Removal of fibrin to restore vessel patency
Fibrinolysis
Converts plasminogen to plasmin
Tissue Plasminogen Activator
Protein that digest fibrin clot
Plasmin
Primary inhibitor of free plasmin
Alpha 2 - Antiplasmin
Final stage of coagulation
Fibrinolysis
cleaves fibrinopeptides A and B
Thrombin
Storage site of von Willebrand factor in platelets
α-granules
Condition wherein there’s FVIII deficiency
Hemophilia A
Condition wherein there’s FIX deficiency
Hemophilia B
Condition wherein there’s FXI deficiency
Hemophilia C o Rosenthal Syndrome
Tenase complex which is composed of factor IXa and its cofactor VIIIa; also activates factor X
Intrinsic tenase
Tenase complex which is composed of factor VIIa and tissue factor
Extrinsic tenase
Converts arachidonic acid to prostaglandin
Cyclooxygenase
Most coagulation factors are synthesized in what organ?
Liver
Carboxylates the factors allowing calcium binding
Vitamin K
Converts fibrinogen to fibrin
Thrombin
Catalyzes the activation of the protein C pathway
Thrombomodulin
A glycosaminoglycan that enhances the activity of antithrombin
Heparan Sulfate
Initial response of the body upon vascular injury
Vasoconstriction
Coagulation factors in Vitamin K Dependent Group/Prothrombin Group
Coagulation Factors II, VII, IX, X
Coagulation factors in Contact Factor Group
Coagulation Factors XI, XII, PreKallikrein, HMWK
Coagulation factors in Fibrinogen Group
Coagulation Factors I, V, VIII, X
True or False: Tissue Factors can be expressed by leukocytes during inflammation?
True
