Coagulation Factors

Question 1

Process by which blood is maintained within the vessel walls

Answer 1

Hemostasis

Question 2

Platelets adhere to each other

Answer 2

Aggregation

Question 3

Platelet roll and “cling to non-platelet surfaces”

Answer 3

Adhesion

Question 4

Primary substrate of thrombin

Answer 4

Fibrinogen

Question 5

Coagulation factor that stabilizes fibrin clot

Answer 5

Factor XIII

Question 6

Other name for Factor XIII

Answer 6

Transglutaminase

Question 7

Required for the assembly of coagulation complexes on platelet or cell membrane phospholipid

Answer 7

Calcium

Question 8

Glycoprotein receptor for fibrinogen

Answer 8

GP IIb/IIIa

Question 9

Glycoprotein receptor for Von Willebrand Factor

Answer 9

GP Ib

Question 10

Induces smooth muscle relaxation and subsequent vasodilation, inhibits platelet activation

Answer 10

Nitric oxide

Question 11

Controls activation of the tissue factor pathway

Answer 11

Tissue factor pathway inhibitor (TFPI)

Question 12

Syndrome in which the platelet GP Ib/IX/V receptor is absent

Answer 12

Bernard-Soulier syndrome

Question 13

Syndrome in which the platelet GP IIb/IIIa receptor is absent

Answer 13

Glanzmann thrombasthenia

Question 14

transmembrane receptor for factor VIIa

Answer 14

Tissue Factor

Question 15

Where can you find Tissue Factor?

Answer 15

Fibroblast and Smooth Muscles

Question 16

Factors V and VIII

Answer 16

Labile Factors

Question 17

tenase complex that composed of factor Xa and its cofactor Va

Answer 17

Prothrombinase

Question 18

Storage site of von Willebrand Factor in the endothelium

Answer 18

Weibel-Palade bodies

Question 19

adhesion molecule that promotes platelets and leukocyte binding

Answer 19

P-selectin

Question 20

protein that inhibits plasmin generation and fibrinolysis

Answer 20

Plasminogen Activator Inihibitor 1

Question 21

Removal of fibrin to restore vessel patency

Answer 21

Fibrinolysis

Question 22

Converts plasminogen to plasmin

Answer 22

Tissue Plasminogen Activator

Question 23

Protein that digest fibrin clot

Answer 23

Plasmin

Question 24

Primary inhibitor of free plasmin

Answer 24

Alpha 2 - Antiplasmin

Question 25

Final stage of coagulation

Answer 25

Fibrinolysis

Question 26

cleaves fibrinopeptides A and B

Answer 26

Thrombin

Question 27

Storage site of von Willebrand factor in platelets

Answer 27

α-granules

Question 28

Condition wherein there’s FVIII deficiency

Answer 28

Hemophilia A

Question 29

Condition wherein there’s FIX deficiency

Answer 29

Hemophilia B

Question 30

Condition wherein there’s FXI deficiency

Answer 30

Hemophilia C o Rosenthal Syndrome

Question 31

Tenase complex which is composed of factor IXa and its cofactor VIIIa; also activates factor X

Answer 31

Intrinsic tenase

Question 32

Tenase complex which is composed of factor VIIa and tissue factor

Answer 32

Extrinsic tenase

Question 33

Converts arachidonic acid to prostaglandin

Answer 33

Cyclooxygenase

Question 34

Most coagulation factors are synthesized in what organ?

Answer 34

Liver

Question 35

Carboxylates the factors allowing calcium binding

Answer 35

Vitamin K

Question 36

Converts fibrinogen to fibrin

Answer 36

Thrombin

Question 37

Catalyzes the activation of the protein C pathway

Answer 37

Thrombomodulin

Question 38

A glycosaminoglycan that enhances the activity of antithrombin

Answer 38

Heparan Sulfate

Question 39

Initial response of the body upon vascular injury

Answer 39

Vasoconstriction

Question 40

Coagulation factors in Vitamin K Dependent Group/Prothrombin Group

Answer 40

Coagulation Factors II, VII, IX, X

Question 41

Coagulation factors in Contact Factor Group

Answer 41

Coagulation Factors XI, XII, PreKallikrein, HMWK

Question 42

Coagulation factors in Fibrinogen Group

Answer 42

Coagulation Factors I, V, VIII, X

Question 43

True or False: Tissue Factors can be expressed by leukocytes during inflammation?

Answer 43

True