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Elle Flashcards - Hematology 2 > Reviewer > Flashcards

Reviewer Flashcards

1
Q

Stages of Hemostasis

A

Vasoconstriction
Primary Hemostasis
Secondary Hemostasis
Fibrinolysis

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2
Q

secretes vWF and tissue factor (F3)

A

Endothelial cells

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3
Q

causes fibrinolysis, activates plasminogen

A

tPA

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4
Q

stops platelet aggregation

A

Prostacyclin

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5
Q

injury to subendothelial wall/ exposed collagen, vWF attaches to collagen with GPIb (Platelet Adhesion), Platelets attach and produce GIIb/IIIa and fibrinogen (Platelet aggregation)

A

Platelet activation

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6
Q

-APTT
-Factors 12,11,9,8
-HMWK activates 12a and 11a
-Activated by collagen

A

Intrinsic Pathway

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7
Q

-PT
-Factor 7, 3
Tissue factor (3) causes factor 7 activation

A

Extrinsic pathway

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8
Q

-starts at Factor 10
-Prothrombin converts to thrombin

A

Common pathway

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9
Q

-converts fibrinogen to fibrin
-activates Factor 13 to support fibrin clot
-Activates Protein C

A

Thrombin

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10
Q

Vitamin K dependent factors

A

2, 7, 9, 10

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11
Q

Prothrombin group

A

2, 7, 9, 10

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12
Q

Fibrinogen group

A

1, 5, 8, 13

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13
Q

plasminogen activates plasmin to dissolve clot

A

Fibrinolysis

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14
Q

-attacks fibrin to degrade it into FDP and D-dimers
-Fibrinogen goes into FDP
-Fibrin goes into D-dimers

A

Plasmin

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15
Q

-neutralizes thrombin, 9a, 10a, 11a, 12a, and plasmin
-heparin acts as cofactor to stop coagulation

A

Antithrombin inhibitor

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16
Q

-most potent fibrinolytic inhibitor
-alpha-2 antiplasmin
-neutralizes plasmin when clot is gone

A

Antiplasmin inhibitor

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17
Q

complexes with Protein S

A

Protein C

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18
Q

-cofactor to APC
-inactivates 5a and 8a

A

Protein S

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19
Q

-in vivo assessment of platelet function
-screens for von Williebrand disease

A

Bleeding time

20
Q

-measures platelet function on chart
-ADP, Epinephrine, collagen, ristocetin and arachidonic acid
-AA: aspirin ingestion screening

A

Platelet aggregometry

21
Q

screen for inhibitors/factor deficiency in extrinsic or common pathway

22
Q

screen for inhibitors/factor deficiency in intrinsic or common pathway

23
Q

-Factor 10 inhibition
-monitors heparin therapy

A

Anti-Xa assay

24
Q

-measures common pathway, hypofibrinogenemia, hyper fibrinogenemia.
-conversion to fibrinogen to fibrin
-Most sensitive for heparin

A

Thrombin Time

25
-measures functional fibrinogen levels -decrease= DIC, fibrinogen lysis, liver disease
Fibrinogen assay
26
- mix patient sample with normal plasma to correct factor deficiencies -No correction= inhibitor present
Mixing studies
27
determines which factor is deficient
Factor Assay
28
- measures Factor 8 inhibitors -Hemophilia A patients
Bethesda titer assay
29
initial LUPUS anticoagulant screen
drVVT
30
measure platelet aggregation
vWF testing
31
- 5M Urea Test -detects abnormal clot formation due to Factor 13
Factor 13 screening test
32
fibrin degradation monitor for DIC
D-Dimer
33
- decrease will cause poor response to heparin -DIC, liver disease
Antithrombin
34
-screens for Factor 5 Leiden -cannot degrade Factor 5 Leiden -results in prolonged coagulation and clot formation
APCR
35
- defect in collagen production -Increase BT
Ehlers-Danlos syndrome
36
-decrease vitamin C -causes vessel defects
Scurvy
37
-autoantibodies take platelets to spleen -decrease platelets
Immune thrombocytopenia
38
-common side effect of Unfractionated heparin -heparin binds to F4
Heparin Induced thrombocytopenia
39
-decrease vWF production -nosebleeds, increase BT, variable APTT -abnormal Ristocetin in aggregation (correct when vWF added)
vonWilliebrand's disease
40
-lacks GPIb to bind to vWF -thrombocytopenia, abnormal platelet morphology/function, increase BT -Abnormal Ristocetin in aggregation
Bernard-Souliers
41
-defective GPIIb/IIIa -normal platelet count, increase BT, abnormal clot retraction -Abnormal ADP, collagen, and epinephrine in aggregation
Glanzmann's thrombosthenia
42
-decrease ADP release -Increase BT -Abnormal ADP, collagen, and epinephrine in aggregation
Storage Pool Disease
43
-decrease alpha granules -increase BT, mild thrombocytopenia -normal aggregation
Gray platelet syndrome
44
-inactivates cyclooxyrgenase enzyme -increases BT -destroys platelet permenantly
Aspirin
45
-factor 8 deficiency -spontaneous bleeding, easy bruising, family history -Increase APTT Perform mixing studies and factor assay
Hemophilia A

Elle Flashcards - Hematology 2 (4 decks)

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