Various drugs

Question 1

Symptoms of systemic calicylic acid toxicity (salicylism)

Answer 1

tinnitus, dizziness, hyperpnea, psychological disturbances

Question 2

Isotretinoin (Accutane)

Answer 2

Acne medication that can elevate triglyceride levels; blood triglyceride levels should be measured befor treatment and periodically during; cannot be taken with vitamin A supplement becauese of potential of increased toxicity since it’s a metabolite of vitamin A

Question 3

Azelaic acid (Azelex)

Answer 3

acne medication to treat mild to moderate acne by supressing growth of Propionibacterium acnes and decreasing proliferation of keratinocytes

Question 4

silver sulfadiazine (Silvadene)

Answer 4

an antibacrial that has a broad spectrum of activity against gram-negative bacteria, gram-positive bacteria and yeast; applied directly to wound to assist in healing. does not stain skin.

Question 5

Bleomycin

Answer 5

an antineoplastic medication that can cause interstitial pneumonitis which can progress to pulmonary fibrosis; pulmonary function studies along with hematological, hepatic and renal function tests need to be monitored. nurse checks lung sounds for dyspnea nad crackles which indicat pulmonary toxicity.

Question 6

Busulfan (Myleran, Busulfex)

Answer 6

used to treat myelocytic leukemia; can cause an increase in uric acid level; hyperuricemia can produce uric acid nephropathy, renal stones and acute renal failure

Question 7

Etoposide (Toposar)

Answer 7

Antineoplastic medicatoin that causes orthostatic hypotension specifically.

Question 8

Vincristine (Oncovin, Vincasar)

Answer 8

Antineoplastic drug with specific side efect of peripheral neuropathy.

Question 9

Asparaginase (Elspar)

Answer 9

Antineoplstic drug contraindicated if hypersensitivity eists, in pancreatits or if the client has a history of pancreatitis; it impairs pancreatic function and pancreatic function tests should e performed; monitor for S&S of pancreatitis: nausea, vomiting, ab pain.

Question 10

Tamoxifen

Answer 10

Antineoplstic med that competes with estradiol for binding to estrogen in tissue containing high concentrations of receptrs; used to Tx metatstatic breast carcinoma in F and M; also effective in delaying recurrence of cancer following mastectomy.; it reduces DNA synthesis and estrogen response; it may increase calcium, cholesterol and triglyceride levels.

Question 11

Cyclophosphamide

Answer 11

Antineoplastic drug that can cuase cstitis; pt must drink copious amounts of fluid; monitor urine output for hematuria; take on empty stomach; can cause hyperkalemia.

Question 12

Daunorubicin (DaunoXome)

Answer 12

Antineoplastic drug that can cause cardiotoxicity; can manifest as CHF; bown marrow depression too; nausea and vomitting is frequesnt side efect that begins a few hours after admin and lasts 24048 hrs; fever is frequent side effect; diarrhea ocassionally.

Question 13

Extravasation

Answer 13

Redness and swelling and slowed infusion; infusion is stopped and physician is notified. Ice or heat may be prescribed for application to the site and an antidote may be prescribed t.