Cardiac Drugs Flashcards

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1
Q

Indications for ACE inhibitors

A

Hypertension, heart failure, diabetic and nondiabetic nephropathy, myocardial infarction, and prevention of cardiovasucular events in patients at risk.

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2
Q

Suffix for ACE inhibitors

A

“pril”: i.e.benazepril, captopril, enalapril, enalaprilat, fosinopril, lisinopril…

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3
Q

Common AEs of ACE inhibitors

A

first-dose hypotension, hyperkalemia, cough, angioedma, renal failure, and fetal injury!

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4
Q

Indications for ARBs

A

hypertension, heart failure, diabetic nephropathy and MI, and prevention of cardiovasucar ivents in patients at risk.

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5
Q

AEs of ARBs

A

Angioedema, fetal harm, renal failure and possibly cancer., hypotension

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6
Q

Aliskiren

A

The only Direct Renin Inhibitor

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7
Q

Indications for Aliskiren

A

Hypertension only

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8
Q

AEs of Aliskiren

A

Not much at low doses; at high does - diarrhea fetal injury

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9
Q

Aldosterone antagonists

A

Only 2: eplerenone and spironolactone; indicated for hypertension and heart failure.

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10
Q

Calcium Channel blockers: 3 classes

A

dihydropyridines, phenyallkylamine and benzothiazepine

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11
Q

examples of Dihydropyridines

A

Nifedipine, amlodipine, clevidipine, felodipine, isradipine, nicardipine, nimodipine, nisoldipine

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12
Q

Site of action of dihydropyridines

A

primarily on arterioles

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13
Q

Site of action of verapmil and diltiazem

A

arterioles and the heart

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14
Q

Indications of verapamil

A

angina pectoris, essential hypertension, cardiac dysrhythmias.

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15
Q

AEs of verapamil:

A

constipation, dizziness, facial flushing, headache, and edema of ankles and feet (all due to vasodilation)

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16
Q

the only benzothiazepine

A

Diltiazem; very much like verapamil

17
Q

The drug of the Phenylalkylamines

A

Verapamil

18
Q

Examples of Dihydropyridines

A

Nifedipine, amlodipine (Norvasc)), clevidipine OCleviprex), isradipine (DynaCirc), Nicardipine (Cardene), Nimodipine (Nimotop) and nisoldipine (Sular)

19
Q

MOA of hydralazine

A

causes selective dilation of arterioles; little or no effect on veins; effect on arteriles results from direct action on vascular smooth muscle