Cardiac Drugs Flashcards
Indications for ACE inhibitors
Hypertension, heart failure, diabetic and nondiabetic nephropathy, myocardial infarction, and prevention of cardiovasucular events in patients at risk.
Suffix for ACE inhibitors
“pril”: i.e.benazepril, captopril, enalapril, enalaprilat, fosinopril, lisinopril…
Common AEs of ACE inhibitors
first-dose hypotension, hyperkalemia, cough, angioedma, renal failure, and fetal injury!
Indications for ARBs
hypertension, heart failure, diabetic nephropathy and MI, and prevention of cardiovasucar ivents in patients at risk.
AEs of ARBs
Angioedema, fetal harm, renal failure and possibly cancer., hypotension
Aliskiren
The only Direct Renin Inhibitor
Indications for Aliskiren
Hypertension only
AEs of Aliskiren
Not much at low doses; at high does - diarrhea fetal injury
Aldosterone antagonists
Only 2: eplerenone and spironolactone; indicated for hypertension and heart failure.
Calcium Channel blockers: 3 classes
dihydropyridines, phenyallkylamine and benzothiazepine
examples of Dihydropyridines
Nifedipine, amlodipine, clevidipine, felodipine, isradipine, nicardipine, nimodipine, nisoldipine
Site of action of dihydropyridines
primarily on arterioles
Site of action of verapmil and diltiazem
arterioles and the heart
Indications of verapamil
angina pectoris, essential hypertension, cardiac dysrhythmias.
AEs of verapamil:
constipation, dizziness, facial flushing, headache, and edema of ankles and feet (all due to vasodilation)