Varicella-zoster Flashcards
1
Q
Type of microbe?
A
Double stranded DNA enveloped
2
Q
Spread?
A
Casual contact and respiratory droplets
3
Q
Clinical significance?
A
Primary infection - (chicken pox)
Reye syndrome (acute encaphalopathy + fatty liver)
Recurrent infection - herpes zoster or shingles
4
Q
Where does it remain latent?
A
Trigeminal and thoracic/ lumbar dorsal root ganglia
5
Q
Treatment?
A
Acyclovir
6
Q
Pathogenesis?
A
Upper-respiratory Spreads to regional lymph nodes Spreads to spleen and liver Infection - vesicular rash Enters cutaneous neurones - migrates to the ganglia - latency
