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Infection Case Studies > EBV? > Flashcards

EBV? Flashcards

1
Q

Type of microbe?

A

Double stranded DNA

Enveloped

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2
Q

Clinical significance?

A

Infection mononucleosis

Burkit’s lymphoma

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3
Q

Signs and symptoms of IM?

A 
Pharyngitis 
Enlarged cervical lymph nodes 
Splenomegaly 
Elevated LFTs 
Atypical lymphocytes - blood film 
Lymphocytosis
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4
Q

How to test for infection?

A

IgM/ IgG Anti-VCA for EBV

Viral capsid antigen

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5
Q

Treatment?

A

Acyclovir

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6
Q

Pathogenesis?

A

Initially replicates - oropharynx`
Infect B cells (C3b receptor blinding)
Latency and immortilsation of B cells

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7
Q

Virulence factors?

A

EBNA1 - segregates epitomes into daughter cells following cell division
Lymphokine - B-cell growth factors

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Infection Case Studies (12 decks)

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