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38 Inhibitors of bacterial cell wall synthesis > Vancomycin, telavancin, bacitracin, fosfomycin > Flashcards

Vancomycin, telavancin, bacitracin, fosfomycin Flashcards

1
Q

Vancomycin - MOA

A

Inhibits transglycosylase, preventing elongation of peptidoglycan and cross-linkage, thus inhibiting cell wall synthesis.

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2
Q

Vancomycin - indications

A

Bone, joint, skin, soft tissue infections.

Pneumonia, septicemia, endocarditis

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3
Q

Vancomycin - adverse effects

A

Red man syndrome + hypotension (when infused at excessive rate).
Nephrotoxicity, ototoxicity (vestibular, cochlear)

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4
Q

Bacitracin - MOA

A

Block the lipid carrier molecule, inhibiting wall synthesis

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5
Q

Bacitracin - Indications

A

Minor skin & ocular infections

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6
Q

Bacitracin - adverse effects

A

Nephrotoxic!! not given systemically

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7
Q

Fosfomycin - MOA

A

Irreversible inhibition of enolpyruvyl transferase, blocking peptidoglycan synthesis

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8
Q

Fosfomycin - Indications

A

Uncomplicated UTI

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38 Inhibitors of bacterial cell wall synthesis (5 decks)

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