Cephalosporins Flashcards
Cephalosporins - groups
Generations 1-4 + advanced generation, cephamycins
Cephamycins (2 drugs)
Cefotetan
Cefoxitin
1st generation cephalosporins (2 drugs)
Cephalexin
Cefazolin
Cephalexin - indications
Skin & soft tissue inf
Cefazolin - indications
Perioperative prophylaxis
Cefotetan - indications
Intra-abdominal inf
Gynecological inf
Biliary tract inf
2nd generation cephalosporins (4 drugs)
Cefprozil
Cefuroxime
Cefotetan
Cefoxitin
Cefprozil and cefuroxime - indications
Respiratory tract, skin, soft tissue infections
Cefoxitin - indications
Surgical prophylaxis
3rd generation cephalosporins (4 drugs)
Ceftazidime
Cefpodoxime
Cefotaxime
Ceftriaxone
Ceftriaxone - indications
Gonorrhea, UTIs, otitis, meningitis, pneumonia, Lyme disease
Single dose treatment for gonorrhea (2 drugs)
Ceftriaxone
Cefpodoxime
Ceftazidime - indications
UTIs
Pneumonia
4th generation cephalosporin (1 drug)
Cefepime
Cefepime - indications
Intra-abdominal inf, UTI, pneumonia, skin & soft tissue inf
Cefepime - adverse effects
Encephalopahty
Advanced-generation cephalosporin (1 drug)
Ceftaroline
Ceftaroline - indications
Pneumonia, skin, soft tissue inf
Cephalosporins - adverse effects
Hypersensitivity and cross-sensitivity with penicillins
Cephalosporins - contraindications
Severe hypersensitivity to penicillin
Cephalosporins associated with additional side effects (4 drugs)
Cefotetan
Cefmetazole
Cefamandole
Cefoperazone
Cefotetan, cefmetazole, cefamandole, cefoperazone - adverse effects
Platelet dysfunction & bleeding
Disulfiram-like reaction with alcohol
Can cephalosporins be used in pt with allergy to other betalactams?
No
