vancomycin Flashcards
vancomycin
tricyclic
glycopeptide
bacteriocidal
MOA
bind to D-ala D-ala terminal-nascent peptidoglycan pentapeptide side chain
inhibit transglycosylation
interfere with
1- elongation of peptidoglycan chain
2- cross-linking
resistance
d-ala d-ala replaced by d-ala d-lactate
enterococci
staphylococci
broad spectrum
g + bacteria
active against
MRSA
activity against
g + anaerobes c. dificile
resistance against
all g - bacilli
treatment of inf. due to PRSP
ceftriaxone + vancomycin
toxicity
phlebitis red man syndrome (flushing due to histamine release) chills fever ototoxicity nephrotoxicity
absorption
poor
oral - bacterial enterocolitis
IV
distribution - widely distributed
excretion
glomerular filtration
MRSA
1- community acquired pneumonia OR pneumonia
2- endocarditis
3- blood stream inf.
meningitis
1-community acquired
2- nosocomial
with gentamycin
enterococcal endocarditis
penicillin allergic patients
endocarditis
strep. viridians
pen. allergic patients
