carbapenems Flashcards
1
Q
classification
A
imipenem
doripenem
meropenem
ertapenem
2
Q
MOA
A
similar to penicillin
3
Q
imipenem spectrum
A
g+ organisms
G- rods
P. aeruginosa
anaerobes
4
Q
imipenem
A
cilastatin
inhibit renal dehydropeptidase 1
inc. plasma half life
inhibit formation of potentially nephrotoxic metabolites
5
Q
drug of choice
A
serratia
citrobacter
enterobacter
6
Q
spectrum
Clark KEEPS PENS In BAG
A
Clarck Clostriduim K Klebsiella pneumoniae E Enterobacter E E.Coli P Proteus mirabilis ,Pseudomonas S Serretia P Providencia species E Enterobacter aerogenes N Neisseria species S Styphylococci,Streptococci,Salmonella species In Influnza B Bacteriodes A Acinetobacter species G Gardnerella vaginalis
7
Q
not effect
A
against MRSA
8
Q
ertapenum
A
no activity against
acinetobacter
pseudomonas
9
Q
for pseudomonal infections
A
carbapenems + aminoglycosides
10
Q
toxicity
Cr, GR seEMS Confused
A
1 carbapenems 2 gi irritation 3 rashes 4 encephlopathy 5 confusion cross allergenicity with penicillins reaction at infusion site
11
Q
therapeutic uses treatment
A
nosocomial infections:
intraabdominal inf.
UTI
pneumonia`
12
Q
treatment
A
febrile neutropenic patients
mixed aerobic + anaerobic inf.
g- bacterial inf.
