other drugs

Question 1

fosfomycin(F)

Answer 1

antimetabolite inhibitor

cystolic enolpyruvate transferase

Question 2

MOA

Answer 2

prevent formation of N-ACETYL-MURAMIC ACID

essential precorsor - peptidoglycan chain formation

Question 3

resistance

Answer 3

dec. IC accumulation

multiple dosing resistance occurs rapidly

Question 4

excretion

Answer 4

kidneys

urinary level - exceed min. inhibitory conc.

Question 5

toxicity

Answer 5

diarrhea rapidly

Question 6

synergism

Answer 6

betalactam + quinolones

7-days treatment with flouroquinolone

Question 7

bacitracin

Answer 7

peptide antibiotic
late stage of cell wall syn.
g+ bacteria
marked nephrotoxicity

Question 8

cycloserine

Answer 8

antimetabolite
block incorporation of d-ala into pentapeptide side chain
potential neurotoxicity (tremors + seizures + phycosis)
only to treat tubercolosis ( org. resistant to 1st line drugs

Question 9

daptomycin

Answer 9

cyclic lipopeptide
spectrum similar to vancomycin
active against VRE +VRS
inserts in cell mem. — cause K+ leak —cell death
elimination – kidney
creatinine phosphokinase should be monitered —cause myopathy