Valvular Heart Disease: Aortic and Mitral Flashcards
As stenosis develops:
Resistance to flow ____
Pressure must ____ to maintain flow
If pressure cannot be ____, then flow will ____
increase
increase
increased; decrease
Formula for Flow
Flow = ?
Pressure/Resistance
Compensatory Mechanisms for Valve Stenosis include?
Hypertrophic remodeling
Increased contractility
As regurgitation develops:
Flow of blood will occur towards the area of?
Hemodynamic consequences depend on?
least resistance
chamber compliance
Formula for Delta Pressure
Delta Pressure = ?
Delta Volume / Compliance
Valve Regurgitation Compensatory mechanisms include?
Chamber dilation to increase compliance and decrease pressure
Increase total stroke volume in order to maintain forward stroke volume
Consequences of Valve Dysfunction
Chamber remodeling results in?
enlargement and hypertrophy
Consequences of Valve Dysfunction
Pressure Overload occurs from which valve dysfunction?
Causes what type of hypertrophy?
Pulmonic Stenosis and Aortic Stenosis
Concentric ventricular hypertrophy
Consequences of Valve Dysfunction
Volume overload occurs from which valve dysfunction?
Causes what type of hypertrophy?
Tricuspid Regurgitation and Mitral Regurgitation
Eccentric Ventricular Hypertrophy
Consequences of Valve Dysfunction
Cardiac ____
Pulmonary ____
Clinical symptoms of?
fibrosis
hypertension
heart failure
Bicuspid Aortic Valve occurs in what % of the population?
These patients are more prone to?
This condition is associated w/?
1-2%
endocarditis
aortopathy and coarctation
Aortic Stenosis Patho
Valvular obstruction leads to?
Leading to what?
Increased Intraventricular pressure to maintain CO
Ventricular walls hypertrophy to reduce wall stress
Aortic Stenosis Patho
Laplace’s Law: Wall Stress = ?
Pressure x radius / 2 x thickness
Aortic Stenosis Patho
LVH leads to?
Decreased compliance
Impaired passive filling
Increased preload dependence on atrial contraction
Aortic Stenosis Patho
Increased LVEDP leads to?
Subendocardial ischemia (decreased myocardial pressure) & pulmonary congestion
Aortic Stenosis Patho
Increased LVEDP and associated problems leads to?
Progressive valvular obstruction
Hypertrophy
Fibrosis
Increasing wall stress
Aortic Stenosis Patho
Progressive valvular obstruction, Hypertrophy, Fibrosis, & Increasing wall stress leads to?
Ischemia
Arrhythmia
Increased filling pressure
Ventricular dilation
Contractile Dysfunction
Decreased EF
Aortic Stenosis Patho
Ischemia, Arrhythmia, Increased filling pressure, Ventricular dilation, Contractile Dysfunction, & Decreased EF leads to?
Angina
Syncope
Dyspnea
Aortic Stenosis Symptoms
Heart failure
SOB/DOE
D/t diastolic dysfunction from hypertrophied LV there is increased pulmonary venous pressure; eventually leading to systolic dysfunction
Aortic Stenosis Symptoms
Angina
Increased LVEDP & Decreased coronary perfusion pressure in setting of LVH leads to subendocardial ischemia,
Concomitant CAD
Aortic Stenosis Symptoms
Occurs due to decreased blood flow to brain?
Syncope
Aortic Stenosis PE
Asymmetric BP in young patients could suggest?
Pulsus tardus et parvus means?
Coarctation w/ a bicuspid valve
Delayed/weak carotid upstroke
Aotric Stenosis PE
Auscultation:
Systolic murmur where?
Murmur intensity correlates w/?
Gallavardin phenomenon is when?
Soft or absent S2 sounds occurs when?
at base radiating to neck
severity
dissociation of the harsh and musical components of murmur
severe
Aortic Stenosis - Diagnostic Testing
Echocardiogram:
Transthoracic shows?
Transesophageal shows?
AVA, Pressure gradients, leflet number, LV function, LVH, Pulmonary HTN
Clarify leaflet number, measure aortic dimension
Aortic Stenosis - Diagnostic Testing
EKG shows?
LVH
LAE
may develop Afib
Aortic Stenosis - Diagnostic Testing
Lab work to collect?
BNP
Aortic Stenosis - Diagnostic Testing
Cardiac Cath shows?
evaluate CAD & hemodynamics
Aortic Stenosis Treatment
Indications for surgery
Severe AS w/ Symptoms
Severe AS w/ EF < 50%
Severe AS undergoing another cardiac surgery
Aortic Stenosis Treatment
Medical Therapy
No medical therapy specifically for AS
Treat concomitant HTN, CAD, Afib
Less invasive option for AVR is?
TAVR - Transcatheter Aortic Valve Replacement
AR -Etiology
More Common (chronic causes)?
Bicuspid aortic valve
Calcific degeneration
Dilated Aorta
Rheumatic HD
AR Etiology
Acute Causes
Infective endocarditis
Dissection of the ascending aorta
Trauma
AR Patho
Regurgitation of the arotic valve occurs because of incomplete closure of the valve due to one or both of the following?
Valve problem
Dilation of the aorta
AR Patho
Sudden large regurgitant volume imposed on LV of normal (or small) size w/ normal (or decreased) compliance leads to?
Rapid increased LVEDP and Increased LAP
LV attempts to maintain CO w/ Increased HR and Increased Contractility
AR Patho
Attempts to maintain forward SV/CO may be inadequate leading to which three problems?
Pulmonary Edema (Increased LVEDP and Increased LAP)
Cardiogenic Shock (Decreased forward SV/CO)
Myocardial Ischemia (decreased CPP, Increased myocardial O2 demand)
AR Patho
Regurgitant Volume leads to what compensatory mechanism?
1) Increased LV dilation leading to Increased LVED volume & Increased Chamber compliance
2) Increased LV hypertrophy (eccentric & concentric) stimulated by Increased LV afterload
AR patho
The compensatory mechanisms maintain what?
a relatively low LVEDP, adequate forward SV/CO, and sufficient coronary perfusion pressure
AR Patho
Compensation leads to Decompensation which results in?
Steadily increasing regurgitant volume load
Further ventricular dilation leading to wall stress
Inability to continue further hypertrophy to decrease afterload
Contractile dysfunction leading to Decreased EF/SV/CO and Increased LVEDP
AR Patho
Decompensation results in what?
CHF Symptoms
Angina (decreased CPP and Marked LVH)
Acute AR - Presentation
Hx includes
Dissection
Endocarditis
Severe dyspnea
Respiratory distress
Acute AR - Presentation
PE includes
Pulmonary Edema
LV heave w/ hyperdynamic precordium
Soft diastolic murmur at left lower sternal border; may not be audible
Physical signs of endocarditis or dissection
Chronic AR - Presentation
Hx includes
Symptoms will depend on LV function
DOE, fatigue, HF