Vaginitis and vaginosis Flashcards
Opportunistic caused of vaginitis/vaginosis
Candida albicans and glabrata
Gardnerella vaginalis
Mobiluncus
Disruption of what kind of normal flora promotes growth of Candida, Gardnerella, and Mobiluncus?
Lactobacilli, flora that help maintain and acidic pH and produce H2O2
List some factors associated with opportunistic vaginitis/vaginosis.
Abx, douching, tight underwear, onset of menses, initial use of IUD, pregnancy, sex
Besides the vagina, where else are Candida, Gardnerella, and Mobiluncus found?
Intestine
Is trichomonas sexually transmitted?
YES! NOT part of normal flora
What else does trich cause besides vaginitis/osis?
Urethritis in males
White discharge
Candida or BV
Yellow discharge
Trich
Clumpy discharge
Candida
Discharge uniformly coats vagina
BV
Fishy smell
BV
Lactobacilli predominate in microscopy
Normal
Normal vaginal pH
4.5
Discharge pH > 4.5
BV, trich
Leukocytes in discharge
Candida, trich
Clue cells
BV (Gardnerella coating epithelial cells)
Scant discharge
Candida
Profuse discharge
Trich
Frothy discharge
Trich
Dysuria
Candida, trich
Cystitis, pyelo, cervicitis
Vulvar itching
Candida, trich
No erythema
Normal, BV
Introitus
Candida
Colpitis macularis
“Strawberry cervix” = trich
Vulvar fissure
Candida
normally open but can look closed d/t Candidiasis-induced edema
Mycelia/pseudomycelia on microscopy
Candida
mass of branching hyphae
Leukocytes in the urine
Cystitis
WBC/RBC casts in the urine
Pyelo
Suprapubic pain
Cystitis, pyelo
Fever
Pyelo
Mucopurulent discharge
Cervicitis
Flank/back pain
Pyelo
> 10^5 bacteria in the urine
Cystitis. pyelo
(T/F): BV and Candidiasis cannot be passed from a female to a male
False; they can be sexually transmitted but generally are d/t overgrowths
Candidiasis vs. trichomoniasis
Both will have dysuria, discharge, vulvar erythema and itching, but Candida will produce scant, clumpy, white discharge with pH ~ 4.5 while trich will produce abundant, yellow, frothy discharge with pH > 4.5
Candida vs. BV
Both will have white, clumpy discharge but BV D/C will be stanky with pH > 4.5; Candida will cause vulvar edema and erythema and have leukocytes on microscopy
BV vs. trichomoniasis
Both will cause discharge, pH > 4.5, and can be smelly but BV will cause adherent white discharge with Clue cells while trich causes yellow, frothy discharge with leukocytes and vulvar erythema
Clear discharge
Normal
Use KOH in diagnosis
Candida - to isolate
BV - for whiff test
What causes malodorous smell of BV discharge during whiff test?
KOH causes amine release, which has a fishy smell
Usually the only sx of BV is:
Discharge
Can be cultured
Candida or trich if clinical signs suggest infection but other tests are negative
Tx candidiasis
Azoles
Tx trich
Metronidazole
Tx BV
Metronidazole or clindamycin
Required tx of partner
Trich
A patient returns to your office with persistent white vaginal discharge and vulvar itching despite stated compliance with a 7 day course of imidazole prescribed 9 days ago. What might be the problem?
Infection with Candida glabrata, which is associated with treatment failure “not uncommonly”