Non-neoplastic - female

Question 1

How would this lesion look histologically?

Answer 1

Multinucleated cells with intra-nuclear inclusion

(HSV)

Question 2

A woman with this endometrial finding is at increased risk of:

Answer 2

Osteoporosis/hip fracture

(Atrophic endometrium = postmenopausal = decreased estrogen)

Question 3

Dx?

Answer 3

Simple endometrial hyperplasia

(Glandular crowding + irregularly shaped glands)

Question 4

Risk factors for this type of infection?

Answer 4

DM, pregnancy, OCP

(Candidiasis - note curdy white appearance)

Question 5

How would infection with these organisms present in a female?

Answer 5

Heavy, foamy vaginal discharge

Itchy

Cervicovaginitis

(Trichomoniasis)

Question 6

Which hormone is elevated in the patient from which this tissue was biopsied?

Answer 6

Estrogen

(Straight glands - proliferative phase)

Question 7

Dx?

Answer 7

Simple atypical hyperplasia

(Nuclear atypica + good amount of stroma)

Question 8

A pregnant patient presents with vaginal itching and a white discharge. What might you expect to see on PE?

Answer 8

Curdled, white discharge with a white mucosal surface

(Pregnancy predisposes to Candidiasis, which will be itchy with a white discharge)

Question 9

What event preceded this phase of endometrial growth?

Answer 9

Ovulation

(Cysts in cytoplasm of simple epithelial cells lining glands = early secretory phase)

Question 10

If a biopsy of the endometrium was taken 2 days before menses, how would the endometrium look?

Answer 10

Tortuous, dilated glands, spiral arteries

Question 11

Dx?

Answer 11

Complex atypical endometrial hyperplasia

(Notice almost all glands without stroma)