Vagina Flashcards
what is epithelium of vagina
mucosa lined by non-keratinizing squamous epithelium
what is vaginal adenosis
focal persistence of columnar epithelium in upper vagina
what is the epithelium of lower 1/3 vagina during development? what is it derived from
squamous epithelium
urogenital sinus
what is epithelium of upper 2/3 vagina during development? What is it derived from?
columnar epithelium
Mullerian ducts
describe the vaginal development
squamous epithelium grows upward to replace columnar epithelium
who usually gets vagina adenosis
females who were exposed to diethylstilbestrol (DES) in utero
what is clear cell adenocarcinoma of vagina
malignant proliferation of glands with clear cytoplasm
clear cell adenocarcinoma of the vagina is a complication of what
DES-associated vaginal adenosis
what is embryonal rhabdomyosarcoma
malignant mesenchymal proliferation of immature skeletal muscle
clinical feature of embryonal rhabdomyosarcoma
bleeding and grape-like mass protruding from vagina or penis of child ( 5 yrs or less)
another name for embryonal rhabdomyosarcoma
sarcoma botryoides
what is a characteristic cell of sarcoma botryoides name? and describe it
Rhabdomyoblast
- cytoplasmic cross-striations
- positive immunohistochemical staining for desmin and myogenin
what is vaginal carcinoma
carcinoma arising from squamous epithelium lining the vaginal mucosa
what is vaginal carcinoma usually related to
high-risk HPV
what is the precursor lesion for vaginal carcinoma
vaginal intraepithelial neoplasia ( VAIN)
