Ovarian Tumors Flashcards
what are the 3 cell types in ovary
surface epithelium
germ cells
sex cordstroma
what is the most common type of ovarian tumor
surface epithelial tumor
surface epithelial tumors are derived from what
coelomic epithelium that lines ovary ....also lines: -fallopian tube ( serous cells) -endometrium -endocervix ( mucinous cells)
what are 2 common subtypes of surface epithelium
serous and mucinous
both usually cystic
benign tumors ( cystadenomas) are composed of what
single cyst with simple, flat lining
premenopausal women 30-40
malignant tumors ( cystadenocarcinomas) are composed of what
complex cysts with thick, shaggy lining
post menopausal women 60-70
BRCA1 mutation carrier have an increased risk for what
serous carcinoma of ovary and fallopian tube
What is a Brenner tumor
Subtype surface epithelial tumor: bladder-like epithelium, benign
when do surface tumors clinically present and how do they present
late with vague abdominal symptoms (pain and fullness) or signs of compression (urinary frequency)
Poor prognosis
where does surface epithelial carcinomas tend to spread
peritoneum
what is the 2nd most common type of ovarian tumor
germ cell tumor
who usually gets germ cell tumor
women of reproductive age
What is a choriocarcinoma
cytrotrophoblasts and syncytiotrophoblasts
- mimics placental tissue but villi absent
What is an endodermal sinus tumor
mimics yolk sac
What is a dysgerminoma
mimics oocytes
What is a cystic teratoma
fetal tissue
BENIGN
struma oavarii is a teratoma composed of what
thyroid tissue
What is the most common malignant germ cell tumor
Dysgerminoma
what is the testicular counterpart of Dysgerminoma
seminoma
What are serum levels for dysgerminoma
LDH may be elevated
what is the most common germ cell tumor in children
endodermal sinus tumor
what is serum levels for endodermal sinus tumor
AFP often elevated
what is seen in histo for endodermal sinus tumor
Schiller-Duval bodies ( glomerulus-like structures)
what hormone levels are high for choriocarcinoma tumor? What can this lead to
beta-hCG ( produced by syncytiotrophoblasts)
- thecal cysts in ovary
