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Ch. 13 Female Genital System and Gestational > Ovarian Tumors > Flashcards

Ovarian Tumors Flashcards

1
Q

what are the 3 cell types in ovary

A

surface epithelium
germ cells
sex cordstroma

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2
Q

what is the most common type of ovarian tumor

A

surface epithelial tumor

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3
Q

surface epithelial tumors are derived from what

A 
coelomic epithelium that lines ovary
....also lines:
-fallopian tube ( serous cells)
-endometrium 
-endocervix ( mucinous cells)
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4
Q

what are 2 common subtypes of surface epithelium

A

serous and mucinous

both usually cystic

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5
Q

benign tumors ( cystadenomas) are composed of what

A

single cyst with simple, flat lining

premenopausal women 30-40

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6
Q

malignant tumors ( cystadenocarcinomas) are composed of what

A

complex cysts with thick, shaggy lining

post menopausal women 60-70

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7
Q

BRCA1 mutation carrier have an increased risk for what

A

serous carcinoma of ovary and fallopian tube

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8
Q

What is a Brenner tumor

A

Subtype surface epithelial tumor: bladder-like epithelium, benign

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9
Q

when do surface tumors clinically present and how do they present

A

late with vague abdominal symptoms (pain and fullness) or signs of compression (urinary frequency)

Poor prognosis

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10
Q

where does surface epithelial carcinomas tend to spread

A

peritoneum

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11
Q

what is the 2nd most common type of ovarian tumor

A

germ cell tumor

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12
Q

who usually gets germ cell tumor

A

women of reproductive age

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13
Q

What is a choriocarcinoma

A

cytrotrophoblasts and syncytiotrophoblasts

- mimics placental tissue but villi absent

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14
Q

What is an endodermal sinus tumor

A

mimics yolk sac

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15
Q

What is a dysgerminoma

A

mimics oocytes

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16
Q

What is a cystic teratoma

A

fetal tissue

BENIGN

17
Q

struma oavarii is a teratoma composed of what

A

thyroid tissue

18
Q

What is the most common malignant germ cell tumor

A

Dysgerminoma

19
Q

what is the testicular counterpart of Dysgerminoma

A

seminoma

20
Q

What are serum levels for dysgerminoma

A

LDH may be elevated

21
Q

what is the most common germ cell tumor in children

A

endodermal sinus tumor

22
Q

what is serum levels for endodermal sinus tumor

A

AFP often elevated

23
Q

what is seen in histo for endodermal sinus tumor

A

Schiller-Duval bodies ( glomerulus-like structures)

24
Q

what hormone levels are high for choriocarcinoma tumor? What can this lead to

A

beta-hCG ( produced by syncytiotrophoblasts)

- thecal cysts in ovary

25
Q

Is embryonal carcinoma aggressive

A

yes

early metastasis

26
Q

what is sex cord-stromal tumors

A

resemble sec cord-stromal tissues of ovary

27
Q

What are 3 types of sex cord-stromal tumors

A

Granulosa-theca cell tumor
Sertoli-Leydig cell tumor
Fibroma

28
Q

what is granulosa-theca cell tumor

A

neoplastic proliferation of granulosa and theca cells

29
Q

what are clinical signs for granulosa-theca cell tumor

A

estrogen increased

  • prior to puberty: precocious puberty
  • reproductive age: menorrhagia and metrorrhagia
  • postmenopause ( most common): endometrial hyperplasia with uterine bleeding
30
Q

histo for Sertoli-leydig tumor

A

Reinke crystals

31
Q

what is fibroma

A

benign tumor of fibroblasts

32
Q

what is fibroma associated with

A

pleural effusions and ascites (miegs syndrome)

33
Q

what is Meigs syndrome

A

triad of benign ovarian tumor with ascites and pleural effusion that resolves after resection of the tumor.

34
Q

What is Krukenberg tumor

A

metastatic mucinous tumor
- both ovaries

cause: metastatic gastric carcinoma

35
Q

what is pseudomyxoma peritonei

A

massive amounts of mucus in peritoneum

Cause: mucinous tumor of appendix
mats to ovary

36
Q

What is an endometrioid tumor

A

Subtype surface epithelial tumor: endometrial-like glands, malignant

Ch. 13 Female Genital System and Gestational (7 decks)

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