Vaccine Delivery

Question 1

Some vaccines can be administered topically, such as the ___ vaccine.

Answer 1

HPV

Question 2

Some vaccines can be administered into the skin, such as the___ vaccine.

Answer 2

BCG

Question 3

Methods of vaccine delivery

Answer 3

1. Injection
2. Oral
3. Nasal
4. Topical
5. Intradermal

Question 4

Delivery of antigens from oil-based adjuvants such as ___ adjuvant led to a reduction in the number of doses of vaccine to be administered.

Answer 4

Freunds

Question 5

FDA approved adjuvants for human uses are

Answer 5

aluminium hydroxide & aluminium phosphate

Question 6

Liposomes and their derivatives ____ (liposome/DNA complexes) are hollow spherical constructs of phospholipid bilayers capable of entrapping hydrophilic moieties in the ___ compartment and hydrophobic moieties in the ____ with cholesterol imparting rigidity to the bilayer.

Answer 6

“lipoplexes”, aqueous, lipid bilateral

Question 7

Micelles

Answer 7

self aggregated clusters of amphiphilic surfactant molecules.

Question 8

Nano-sized emulsion particles may exist in the form of oil in water and water in oil, where the droplet size may vary from _________

Answer 8

50 nm to 600 nm

Question 9

Vaccine delivery systems

Answer 9

1. Liposomal delivery systems
2. Emulsion delivery system
3. Micellar delivery system
4. Edible vaccines
5. Virus-like particles
6. Polymeric nanoparticles
7. Emulsions

Question 10

Components of vaccine delivery systems

Answer 10

1. Cold
2. Vaccine supply
3. Vaccine administration
4. Vaccine monitoring
5. Vaccine information