UWorld Review 2 Flashcards
Describe the etiology, presentation, diagnosis, lab findings, and management of infectious mononucleosis.
- most commonly caused by EBV
- presents with prolonged course of fever, fatigue, pharyngitis with or without exudates, tender cervical or diffuse lymphadenopathy, and hepatosplenomegaly
- a rash may appear if given amoxicillin
- diagnosis is typically with a mono spot test positive for heterophiles antibodies; perform anti-EBV antibody testing instead for children under 4
- blood smear will show atypical lymphocytes and labs show a transient hepatitis
- manage with avoidance of contact sports for at least four weeks due to the risk of splenic rupture
What are the Centor criteria?
a set of criteria used to evaluate for GAS pharyngitis
- age 14 or less
- cervical adenopathy
- pharyngeal exudates
- fever
- absence of a cough
for those with 2-3 points, perform GAS testing; for those with 4-5 points consider empiric treatment with amoxicillin
Describe the presentation, diagnosis, and treatment of GAS pharyngitis.
- presents with sore throat, cervical adenopathy, pharyngeal exudates, fever, and no cough
- rapid strep test is the best first test; can follow with a throat culture if rapid is negative
- will typically resolve on it’s own within one week without treatment, but amoxicillin is used to prevent rheumatic fever
- use cephalexin for those with penicillin allergy causing rash; use clindamycin or a macrolide for penicillin allergy causing anaphylaxis
What is the standard recommendation for colorectal cancer screening?
every 10 years starting at age 50
What is the recommendation for colorectal cancer screening in those with risk factors (family history of CRC, personal history of CRC, personal history of IBD)?
- single family member: begin at 40 or 10 years younger than age of the family member; repeat every 5 years if the family member was less than 60
- 3 family members across 2 generations with 1 before age 50 (HNPCC): start at age 25 and repeat every 1-2 years
- familial adenomatous polyposis (FAP): sigmoidoscopy at age 12 and repeat every year
- previous adenomatous polyp: colonoscopy every 3-5 years
- previous CRC: colonoscopy 1 year post-resection, 3 years post-resection, then every 5 years
- history of IBD: 8-10 years post-diagnosis, then repeat every 1-2 years
Describe the diagnosis and treatment of ADHD.
- diagnosis requires 6 months of symptoms (inattention, hyperactivity, etc.) that interfere with daily functioning in two areas with symptoms present since at least age 12
- first-line treatment are stimulants
- atomoxetine is a second-line agent with fewer side effects and less abuse potential
- alpha-2 agonists (clonidine and guanfacine) are second-line agents helpful for comorbid tic disorders, but have no benefit in adult populations
How does acute mediastinitis presents and how is it treated?
- presents with fever, chest pain, leukocytosis, and mediastinal widening on CXR
- it requires surgical drainage and prolonged antibiotics
How should afib be treated in the post-CABG patient?
- in this case it is a common and usually self-limited
- rate control with beta-blockers or amiodarone is best in these cases lasting less than 24 hours
- antigoculation and/or cardioversion should only be used for cases that persist for longer than 24 hours
What is the difference between atrial flutter and atrial fibrillation?
fluter is a regular rhythm that tends to return to sinus or deteriorate into fibrillation which is an irregularly irregular rhythm
Describe the management of atrial fibrillation.
- for hemodynamically unstable patients, the first step is synchronized electroconversion
- for acute but stable patients with an exogenous cause (post-CABG, cocaine, alcohol, etc.), rate control is all that is necessary; most cases with spontaneously revert
- chronic cases (lasting >48 hours) should be managed with rate control first (beta-blockers, CCBs, or digoxin) and then started on anticoagulation (NOACs preferred in most cases, warfarin for mitral stenosis or metal valves, aspirin for CHADS-VASC less than 2)
What is the most significant complication of succinylcholine use? How does its mechanism of action contribute? How can it be avoided?
- it is a depolarizing neuromuscular blocker that binds postsynaptic acetylcholine receptors, triggering an influx of sodium ions and efflux of potassium
- this may contribute to hyperkalemia and cardiac arrhythmias, especially in patients already at risk for hyperkalemia (crush injury, burn injury, etc.)
- in such patients, use a non-depolarizing agent like vecuronium or rocuronium
What is the most significant complication for each of the following anesthetics:
- succinylcholine
- halothane
- etomidate
- nitrous oxide
- propofol
- succinylcholine: hyperkalemia and cardiac arrhythmia
- halothane: acute liver failure
- etomidate: inhibition of 11B-hydroxylase and adrenal insufficiency
- nitrous oxide: vitamin B12 inactivation and deficiency
- propofol: myocardial depression and severe hypotension
Describe the spectrum of rashes that are attributable to drug hypersensitivities and which drugs are common offending agents.
- caused by the same agents that cause hemolysis, drug-induced thrombocytopenia, and interstitial nephritis
- these include penicillins, sulfa drugs, allopurinol, phenytoin, lamotrigine, and NSAIDs
- the mildest is a morbilliform rash: there is no mucous membrane involvement and the skin stays intact
- erythema multiform is a defined by widespread, small target lesions that spare the mucous membranes
- SJS involves the mucous membranes and sloughing; sloughing of the respiratory epithelium can lead to respiratory failure
- TEN is SJS which involves a greater portion of the skin and has a positive Nikolsky sign
- treat SJS and TEN with IVIG
Describe the etiology, presentation, and treatment of erythema multiforme.
- most commonly a drug hypersensitivity reaction or a manifestation of herpes simplex virus
- presents as small, erythematous, round papules that evolve into target lesions
- treat symptomatically with antihistamines and topical glucocorticoids
Describe the presentation, diagnosis, and management of fibrocystic changes of the breast.
- presents with nodular tissue bilaterally, often accompanied by diffuse, cyclical, premenstrual tenderness
- it is a clinical diagnosis based on exam findings
- management involves observation; NSAIDs and cOCPs can be offered for pain management
Describe the pathophysiology and management of symptomatic cholelithiasis in pregnancy.
- estrogen causes increased biliary cholesterol excretion while progesterone reduces gallbladder motility
- patients are managed conservatively with pain control
since most cases resolve - cholecystectomy is reserved for complicated or recurrent cases
Describe the five options and timing of genetic testing available in the prenatal period.
- in the first trimester, between 9-13 weeks, a combined test of maternal B-hCG, maternal PAPP-A, and nuchal translucency can be performed as a screening tool
- in the first trimester, after 10 weeks, cell-free fetal DNA testing can be performed as a screening tool
- in the second trimester, between 15-20 weeks, a triple or quad screen can be performed with MSAFP, B-hCG, estriol, and (for the quad) inhibin A
- CVS is a confirmatory test performed at 10-13 weeks
- amniocentesis is a confirmatory test performed at 15-17 weeks
What routine prenatal testing is performed in each of the trimesters?
- in the first trimester, a dating ultrasound, pap smear, and G/C are performed along with routine blood tests
- in the second trimester, a routine ultrasound for anatomy is performed at 18-20 weeks
- in the third trimester a 1-hr GTT is performed at 24-28 weeks; a CBC for anemia at 27 weeks; and G/C, STD, and GBS testing at 36 weeks
Describe the geographical distribution, presentation, and diagnosis of histoplasmosis.
- it is most prevalent in the Ohio and Mississippi river valleys, associated with caves and bird droppings
- it presents with respiratory symptoms, hilar adenopathy, non-caveating granulomas, erythema nodosum, and hepatosplenomegaly
- culture is the most accurate test but most often diagnosis is with urine antigen testing
Describe the geographical distribution, presentation, and diagnosis of blastomyces.
- it is most prevalent in the great lakes region and Ohio river valley, associated with soil
- it presents with respiratory symptoms, hazy patchy alveolar infiltrates on CXR, and skin, bone, and prostate lesions
- diagnosis is made with culture
Describe the geographical distribution, presentation, and diagnosis of coccidioidomycosis.
- most prevalent in the southwest US, associated with dust exposure
- it presents with respiratory symptoms, arthritis, erythema nodosum, and occasionally meningitis
- diagnosis is made by culture
Which two organisms that cause UTIs have urease activity? How does this affect the pH of an infected individual’s urine?
- both Proteus mirabilis and Klebsiella pneumoniae have urease activity
- this causes urinary alkalization
The first test of choice when evaluating for bladder cancer is what?
after other causes have been ruled out with UA, cystoscopy and abdominal CT are the next best steps
Under what circumstances should a patient with nephrolithiasis undergo evaluation by urology?
- if they initially present with urosepsis, AKI, anuria, or complete obstruction
- if the stone is found to be greater than 1cm
- if pain is uncontrollable or the stone fails to pass after 4-6 weeks of medical management
Describe the flow-volume loops for obstructive and restrictive lung disease and for fixed upper airway obstruction
- obstructive: shifted toward higher lung volumes with a scooped-out appearance during exhalation as airflow decreases during the effort-independent phase of exhalation
- restrictive: shift toward lower lung volumes with a normal pattern of air flow velocity
- fixed upper airway obstruction: limited airflow during inspiration and expiration causes a flattening fo the top and bottom of the curve with little change in overall volumes
Newborns should undergo what routine preventative measures and what routine screenings?
- prevention: vitamin K, hepatitis B vaccine, silver nitrate and erythromycin eye ointment
- screening: newborn screening, hyperbilirubinemia, hearing, pre- and post-ductal pulse oximetry, hypoglycemia
How do we screen for congenital heart disease in newborns? How should this be followed up?
- screen with pre- and post-ductal pulse oximetry
- follow up with echocardiogram
What is the best way to differentiate primary from central cases of adrenal insufficiency?
aldosterone levels will be normal for cases of central insufficiency because renin rather than ACTH controls release of aldosterone
What are the three key features of vascular dementia?
- significant executive dysfunction
- focal neurologic findings (asymmetric reflexes, urinary frequency, gait abnormalities)
- step-wise decline
What differentiates non-allergic rhinitis from allergic rhinitis? How are the two treated?
- NAR: prominent nasal congestion, postnasal drainage, onset after 20, and erythematous nasal mucosa without any specific triggers
- allergic: more eye symptoms, itching, sneezing, and a pale bluish nasal mucosa with identifiable triggers
- both are treated with intranasal glucocorticoids and antihistamines
GvHD targets what organs?
- skin: maculopapular rash that may generalize
- intestine: bloody diarrhea
- liver: jaundice and abnormal LFTs
How is severe hypercalcemia defined and managed?
- it is defined as serum calcium greater than 14
- short-term management includes normal saline to increase excretion and clacitonin to inhibit osteoclasts
- bisphosphonates are then given for long-term maintenance therapy but won’t be effective for several days
What is exercise-associated hyponatremia?
a phenomenon that affects athletes who ingest large amounts of hypotonic fluid during and immediately following prolonged exercise, which is then complicated by the nonosmotic stimulation (by exertion, pain, hypoglycemia, etc.) of ADH release
What is the only proven effective way to reduce the incidence of catheter-associated UTI?
avoiding unnecessary catheter use, minimizing the duration of catheterization, and replacing catheters often
What role does CT play in the management of pancreatitis?
it is used only when the diagnosis is uncertain or patients fail to improve with standard treatment
How is massive hemoptysis defined and controlled?
- it is defined as more than 600mL in a 24 hour period or rate greater than 100mL/hr
- begin by securing the patients airway
- if bleeding, continues begin with bronchoscopy, then embolization, and finally resection
How should ingestion of a foreign body be managed?
- begin with PA and lateral x-rays to locate the object
- for patients who are symptomatic or have swallowed objects that are sharp, magnetic, or batteries, perform endoscopic removal
- for patients without these high-risk features, serial x-rays can be performed with endoscopic removal only if the object fails to progress
Empiric antibiotic treatment for treatment of a pneumonia in a CF patient must cover what?
use cefepime and vancomycin to cover Pseudomonas and MRSA
What is the pathophysiology for referring syndrome?
- the surge of insulin is ultimately responsible
- it triggers a decrease in serum phos, potassium, and magnesium as well as a rise in sodium and water retention
- manifesting as seizures, wernicke encephalopathy, congestive heart failure, and arrhythmia
Describe the presentation of sick sinus syndrome?
- it is the inability of the SA node to generate an adequate heart rate secondary to age-related fibrosis of the node
- presents with bradycardia, sinus pauses (delayed P waves), and SA exit block (dropped P waves)
What is the hydrogen breath test?
a test for lactose intolerance which is positive if there is bacterial carbohydrate metabolism
When being mechanically ventilated, PaO2 is controlled by what two settings?
FiO2 and PEEP
The two preferred modalities for diagnosing a ureteral stone are what?
non contrast CT or ultrasound
What is the hallmark of hepatorenal syndrome? How is it treated?
- the hallmark are signs of pre-renal AKI that don’t respond to fluids
- treatment is with splanchnic vasoconstrictors midodrine, octreotide, and norepinephrine
Describe the proper evaluation of thyroid nodules.
- begin with a TSH level and thyroid ultrasound
- if the TSH is normal or elevated, consider an FNA - for low TS, perform a radioactive iodine scintigraphy
- a cold nodule should be referred for FNA - a hyper functional nodule should be treated for hyperthyroidism
Describe the presentation of vaginal cancer.
- vaginal bleeding
- malodorous vaginal discharge
- irregular vaginal lesion, typically in the upper third of the posterior vagina
What is chonedrocalcinosis?
calcified articular cartilage on radiographies diagnostic of calcium pyrophosphate dihydrate crystal deposition disease (pseudogout)
What are the features of hereditary hemochromatosis?
- bronze diabetes, hypogonadism, and hypothyroidism
- arthropathy and chondrocalcinosis
- hepatic dysfunction
- cardiomyopathy
Nocturnal watery bowel movements and abdominal cramps are a symptom of what kind of diarrhea?
osmotic diarrhea
What is the most common cause of abnormal uterine bleeding in adolescence?
HPO axis immaturity
Define the following types of chemotherapy:
- adjuvant
- neoadjuvant
- consolidation
- induction
- maintenance
- salvage
- adjuvant: given alongside standard standard therapy
- neoadjuvant: given before induction therapy
- consolidation: follows induction therapy to further reduce tumor burden
- induction: an initial dose of treatment to rapidly kill tumor cells and send the patient into remission
- maintenance: given after induction and consolidation to kill residual tumor cells and maintain remission
- salvage: used for recurrence of cancer
What are exudates and how are they differentiated from transudates?
- exudates are due to an increase in vascular permeability rather than an imbalance of hydrostatic and oncotic pressure
- they are defined by meeting at least one of Light’s criteria: pleural/serum protein ratio > 0.5, pleural/serum LDH ratio > 0.6, or pleural fluid LDH >⅔ upper limit of normal serum LDH
What is the best next step in a patient with acute arterial occlusion leading to a threatened limb?
anticoagulation with IV heparin
What is a short inter pregnancy interval and why is it avoided?
- defined as a period less than 18 months between pregnancies
- complications include maternal anemia and low birth weight as the woman are nutritionally depleted by prior pregnancy
- and preterm delivery or PPROM due to persistent genital tract inflammation caused by previous pregnancy
What is the strongest risk factor for preterm labor? What is the best first step in evaluating the risk of preterm labor?
- a prior preterm labor is the greatest risk factor
- and a transvaginal ultrasound measurement of cervical length in the second trimester is the best assessment
What is fetal fibronectin useful for?
it is an indicator for the risk of preterm labor after 20 weeks gestation (prior to that it is physiologically elevated and not a good indicator)
What is used for preterm birth prophylaxis?
- for women who have either a short cervix or a history of preterm birth, use vaginal or IM progesterone to maintain uterine quiescence
- for those with both, cerclage may be indicated
Describe the etiology, presentation, complications, treatment, and prevention of bronchiolitis.
- most often caused by RSV
- typically presents in children less than 2 with nasal congestion, cough, respiratory distress, and wheezing and crackles on lung auscultation
- may be complicated by apnea in infants less than 2 months old or by respiratory failure
- treatment is supportive
- palivizumab is used for prophylaxis for children less than 2 at high risk: congenital heart disease, chronic lung disease of prematurity, preterm birth before 29 weeks
How can seborrheic dermatitis be distinguished from tinea capitus?
SD is more oily and involves the eyelids, nasolabial folds, and post auricular area; tinea is made up of pruritic, fine, white scales and does not involve these additional structures
Which form of bilirubin is readily excreted in urine?
conjugated, which is the more water soluble
What are three metabolic changes that may exacerbate hepatic encephalopathy?
- hypovolemia
- hypokalemia: intracellular potassium shifts out and hydrogen ions replace them in the intracellular space, leading to an intracellular acidosis which increases ammonia production
- metabolic alkalosis: promotes conversion of ammonium to ammonia, which can enter the CNS
Which anticoagulation alternatives are acceptable for those with HIT?
argatroban and fondaparinux
What is unique about each of the following lung carcinomas:
- adenocarcinoma
- squamous cell
- small cell
- large cell
- adenocarcinoma: most common overall and in nonsmokers, typically a peripheral lesion
- squamous cell: central, necrotic, cavitary lesions associated with hypercalcemia
- small cell: central lesions associated with Cushing syndrome, SIADH, and LEMS
- large cell: peripheral lesions associated with gynecomastia and glaactorrhea
What is situational syncope?
a form of neurally mediated syncope associated with specific triggers like micturition, defecation, or coughing, which alter the autonomic response and can precipitate syncope