UWorld Biology Flashcards
A woman with low serum cortisol due to partial adrenal dysfunction is treated with high doses of a synthetic cortisol analogue. According to Figure 2, treatment with a cortisol analogue will most likely cause this patient’s serum level of endogenous cortisol to:
Decrease.
Adrenal cortex synthesizes cortisol. If theres a high amount, cortisol inhibits the Hypothalamus to stop producing CRH which stops the anterior pituitary from producing ACTH
A drug that blocks the release of adrenocorticotropic hormone from the anterior pituitary would most likely:
A.decrease secretion of cortisol from the adrenal cortex.
B.decrease secretion of thyroid-stimulating hormone from the anterior pituitary.
C.increase secretion of oxytocin from the posterior pituitary.
D.increase secretion of calcitonin from the thyroid.
A.decrease secretion of cortisol from the adrenal cortex.
Which statement best describes the characteristics of hormones secreted from the pituitary gland?
A.Hormones secreted from the posterior pituitary are synthesized in the hypothalamus.
B.Hormones secreted from the posterior pituitary act on other endocrine glands.
C.Hormones secreted from the anterior pituitary only act directly on nonendocrine tissues.
D.Hormones secreted from the anterior pituitary are released by depolarization of the nerve terminals.
A.Hormones secreted from the posterior pituitary are synthesized in the hypothalamus.
Hormones secreted from the hypothalamus to the anterior pituitary are released into the ________
hypophyseal portal system - a network of capillaries that enables small quantities of hormones secreted from the hypothalamus to directly reach the anterior pituitary without being diluted in the circulation
Posterior pituitary hormones are synthesized where?
In hypothalamic neurons and are then transported down the axon to the axon terminals in the posterior pituitary, where they are stored. The secretion of stored hormones in the posterior pituitary are mediated by APs that cause exocytosis of neurosecretory vesicles
pancreas and pituitary gland, respectively
As the two anatomical divisions of the adrenal gland, the adrenal cortex and adrenal medulla share a common feature in that both:
A.synthesize steroid hormones.
B.release signaling molecules into lymph vessels.
C.regulate the synthesis of red blood cells.
D.secrete hormones that alter blood pressure.
D.secrete hormones that alter blood pressure.
Adrenal medulla secretes amino acid (peptide hormones) such as NE and EPI
Adrenal cortex secretes steroid hormones such as glucocorticoids and mineralcorticoids (INCREASES BP)
The adrenal ______ secretes the hormones cortisol and aldosterone, and the adrenal ______ secretes the hormones epinephrine and norepinephrine.
Cortex
Medulla
Patients with CAH exhibit hypoglycemia due to numerous endocrine abnormalities. In healthy individuals, hypoglycemia will trigger an increase in the serum level of:
insulin.
epinephrine.
glucagon.
A.I only
B.II only
C.I and III only
D.II and III only
D.II and III only
When blood glucose levels are low (eg, during periods of fasting), the hormone glucagon is secreted from the alpha cells of the pancreas, and the autonomic nervous system promotes the release of epinephrine and norepinephrine by the adrenal medulla.
Epinephrine and norepinephrine also promote glycogenolysis. Therefore, the overall effect of glucagon, epinephrine, and norepinephrine is to promote the synthesis of glucose and its release into the systemic circulation, thereby correcting the low serum level of glucose.
Intraperitoneal injection of insulin would cause the peptide hormone to enter the bloodstream and exert its effect on target cells by:
A.acting as a second messenger.
B.diffusing through the plasma membrane.
C.binding an extracellular receptor.
D.disassociating from a carrier protein.
C.binding an extracellular receptor.
After a meal, the body is in an energy-rich state (ie, high concentrations of glucose and lipids); as a result, the hormone leptin is released by ____________ to trigger feelings of satiety by communicating to the hypothalamus in the brain that the stomach is full, thereby suppressing appetite.
white adipose tissue
Which of the following is a potential complication of secondary hyperparathyroidism?
A.Decreased bone mineralization
B.Decreased osteoclast activity
C.Increased osteoblast activity
D.Increased cortical bone mass
A.Decreased bone mineralization
PTH increases blood calcium - high osteoclast activity
In response to increased plasma calcium concentration, the peptide hormone calcitonin is secreted by the
thyroid gland
A student analyzing actively dividing cells under the microscope finds that each daughter cell contains half the number of chromosomes as the parent cell. Given this, these cells most likely contain all of the following EXCEPT:
A.peroxisomes.
B.nuclear pore proteins.
C.single-stranded genomic material.
D.microtubules.
C.single-stranded genomic material.
microtubules form the cytoskeleton - shape of the cell
Plasmodium falciparum is a protozoan parasite known to cause malaria, an illness characterized by fever, chills, and flu-like symptoms. Which of the following is the most likely reason why P. falciparum would be classified as a eukaryotic organism?
A.It is able to reproduce sexually.
B.It has a mechanism for intron splicing.
C.It has a cell wall.
D.It has a cell membrane.
B.It has a mechanism for intron splicing.
eukaryotic cells are unique in that they have membrane-bound organelles as well as a mechanism for intron splicing by the spliceosome.
A pathogen identified in a patient’s blood sample is found to lack a phospholipid bilayer. Therefore, any medications used to treat the disease caused by this pathogen would most likely be classified as:
A.antiprotozoal drugs.
B.antifungal drugs.
C.antiviral drugs.
D.antibacterial drugs.
C.antiviral drugs.
bacteria and eukaryotes have phospholipid bilayers
E. coli K-12, a normal bacterial strain of the human microbiota, is able to cause disease by inducing enterocyte lesions after it is grown in media with EHEC bacteria that contain the F factor plasmid. What process most likely granted virulence to E. coli K-12?
A.Transformation
B.Transduction
C.Conjugation
D.Transfection
C.Conjugation
Transformation is the cellular uptake of foreign DNA from the environment.
Transduction involves DNA transfer from one bacterial cell to another by a bacteriophage (a virus that infects bacteria).
Which of the following is most likely to be found within the cell membranes of intestinal epithelial cells?
A.Peptidoglycan
B.Cholesterol
C.Cytoskeletal filaments
D.Cellulose
B.Cholesterol
In addition to phospholipids, animal cell plasma membranes also contain cholesterol, glycolipids (lipids with attached sugar groups), glycoproteins (proteins with attached sugar groups), and other proteins.
Cholesterol, which is found in eukaryotic but not prokaryotic cell membranes
Cytoskeletal filaments are found in the cytoplasm of cells
Which step(s) of the viral life cycle would most likely occur in lytic phages?
Injection of viral genetic material into the bacterial host
Integration of viral DNA into the bacterial genome
Degradation of the host genome
A.I only
B.III only
C.I and II only
D.I and III only
D.I and III only
Lytic: Attachment, injection, host genome degradation, synthesis of viral progeny, virions released due to lysozymes degrading host cell wall
In contrast, phages with a lysogenic life cycle integrate their genome with the host genome and replicate as the cell divides.
A student adds 5 bacterial cells to a test tube containing fresh medium and incubates it for 3 hours at 37°C. If the bacterial population shows an initial lag phase of 20 minutes followed by a doubling time of 40 minutes, what is the approximate number of bacterial cells present at the end of the incubation period? (Note: Assume unrestricted growth during incubation.)
A.20 cells
B.40 cells
C.80 cells
D.160 cells
C.80 cells
Assume a single-celled organism was discovered in water above 100°C. On closer inspection, it is determined that this organism was previously classified under the Archaea domain. Given this information, this organism most likely has:
A.a peptidoglycan layer in its cell wall.
B.a circular chromosome.
C.telomeres.
D.an endoplasmic reticulum.
B.a circular chromosome.
Like bacteria, archaea are unicellular (single-celled), have a circular chromosome, have no membrane-bound organelles or nucleus, and reproduce asexually via binary fission.
Researchers are studying a single-celled pathogen. Which experimental method would be LEAST effective for determining whether the pathogen is prokaryotic or eukaryotic?
A.Analyzing the cells for the number of origins of replication
B.Exposing the pathogen to a fluorescent antimitochondrial antibody
C.Testing the pathogen for ribosome size
D.Assessing the pathogen for the presence of pyruvate in the cytoplasm
D.Assessing the pathogen for the presence of pyruvate in the cytoplasm
Which of the following is true concerning transmembrane proteins?
A.They localize primarily in low-cholesterol environments known as lipid rafts.
B.They are held statically in place by cytoskeletal components.
C.They are able to interact only with the phospholipids on the outer leaflet of the cell membrane.
D.They can migrate laterally through the phospholipid-rich environment of the cell membrane.
D.They can migrate laterally through the phospholipid-rich environment of the cell membrane.
As it matures, the endosomal lumen becomes acidified relative to the cytosol. Protons from the cytosol most likely enter the endosomal lumen by which of the following processes?
A.Simple diffusion
B.Facilitated diffusion
C.Passive transport
D.Active transport
D.Active transport since its acidic in the cytosol it needs to go against gradient
Microtubules make up:
A.ribosomes.
B.centrioles.
C.cilia.
D.centromeres.
B.centrioles.
which of the following best explains how mitochondrial genes differed from eukaryotic genes prior to gene transfer? Mitochondrial genes were:
A.interspersed with noncoding sequences.
B.located on chromosomes without telomeres.
C.present on a single-stranded DNA genome.
D.associated with histones.
B.located on chromosomes without telomeres.
circular DNA
Ponyfish cells containing P. leiognathi symbionts were exposed to a spindle fiber toxin that inhibits microtubule polymerization. Given this information, which of the following would most likely result as a consequence of toxin exposure?
A.P. leiognathi daughter cells with multiple copies of the Cu/Zn SOD gene
B.Ponyfish daughter cells containing the same copy number of the Cu/Zn SOD gene
C.Delayed separation of P. leiognathi cells during binary fission
D.Nondisjunction in somatic ponyfish cells undergoing nuclear division
The mitotic spindle begins to form when centrosomes (microtubule-organizing centers consisting of a pair of centrioles) start migrating to opposite poles of the cell and microtubule filaments grow from them, resulting in spindle fibers.
D.Nondisjunction in somatic ponyfish cells undergoing nuclear division
In anaerobic environments, P. leiognathi can produce energy by using an inorganic final electron acceptor other than oxygen in the electron transport chain. Under anaerobic conditions, which of the following is NOT active in ponyfish cells but active in P. leiognathi?
A.Glycolysis
B.Gluconeogenesis
C.Fermentation
D.ATP synthase
D.ATP synthase
The reduced virulence of lac+ S. typhimurium has been correlated with an inability to generate the torque that turns the flagellum. Which structure in the flagellum is most likely being affected by lac genes?
A.Hook
B.Filament
C.Basal body
D.Cell membrane
C.Basal body
the filament propels bacterium, hook transmits force, basal body works as a motor
Scientists studying evolution in yeast found that a certain species underwent a reduction in chromosome number with no loss of coding information. Given this, which of the following mechanisms best explains how this reduction in chromosome number may have occurred?
End-to-end fusion of two chromosomes followed by inactivation of one centromere on the newly formed chromosome
Breakage of a chromosome at the centromere and fusion of the two resulting chromosomal portions to the ends of other chromosomes
Transfer of a DNA sequence from one chromosomal arm to a different chromosomal arm
A.I only
B.II only
C.I and II only
D.I and III only
C.I and II only
end-to-end (telomere-to-telomere) fusion of two chromosomes and inactivation of one of the centromeres. This fusion would initially generate a larger chromosome with two centromeres, and inactivation of one of these centromeres would produce a single new chromosome, reducing the chromosome number in the cell by one (Number I).
breakage of a chromosome at the centromere and fusion of each chromosomal portion to the ends of other chromosomes. This initial breakage would result in two individual chromosomal portions. Fusion of these portions to other chromosomes would cause the original chromosome to be lost, also reducing the overall chromosome number in the cell by one
Assume bacteria are infected with a vector containing HBV genetic material. This vector has been shown to introduce its genomic content into bacterial cells without fully gaining entry into the bacterial cytoplasm. Based on this information, the vector is most likely a:
A.prion.
B.bacterium.
C.viroid.
D.bacteriophage.
D.bacteriophage.
Which organ synthesizes bile? Which stores it?
Liver synthesizes
Gallbladder stores it
Consequently, bile salts break down large lipid globules into smaller droplets (micelles) in a process known as _______
Emulsification
these lipids have increased SA on which pancreatic lipase can act on
The peritoneum is composed of two membranes that line the abdomen: the _______ layer, which lines the abdominal wall, and the _______ layer, which covers the abdominal organs.
parietal
visceral
The peritoneal cavity is found within the abdomen and contains organs such as the liver, stomach, and intestines.
Stenosis is the abnormal narrowing of a tubular structure in the body, such as a blood vessel. Stenosis of the afferent arterioles in the kidney would be expected to:
A.decrease the glomerular filtration rate.
B.increase blood flow to the glomeruli.
C.decrease resistance in the afferent arterioles.
D.increase output of urine.
A.decrease the glomerular filtration rate.
Cirrhosis of the liver is characterized by hepatic cell death, tissue scarring, and altered liver function. All of the following would be disrupted by cirrhosis of the liver EXCEPT:
A.the production of ketone bodies.
B.the metabolism of most drugs.
C.the oncotic pressure within capillaries
D.the secretion of digestive proteolytic enzymes.
D.the secretion of digestive proteolytic enzymes.
Osmotic pressure within capillaries is due to the presence of plasma proteins that cannot easily cross the capillary membrane. Oncotic pressure causes a “pulling force” inside capillaries, which balances the pushing force of hydrostatic pressure, helping keep fluid in the vasculature. The majority of plasma proteins such as albumin are synthesized in the liver. Therefore, cirrhosis is expected to impact the production of plasma proteins, which in turn would affect oncotic pressure in the capillaries
Ketogenesis (synthesis of ketone bodies) occurs mainly in the ______ and plays a critical role in energy metabolism when glycogen stores are depleted and blood glucose levels become low. During times of fasting, _______within _____cells convert ______ into ketone bodies, which are then used by the brain to make ATP
liver
mitochondria within liver cells
Acetyl CoA
Human cardiac muscle differs from skeletal muscle because it:
A.appears striated.
B.requires acetylcholine to contract.
C.contains intercalated discs.
D.contains cells with multiple nuclei.
C.contains intercalated discs.
it doesnt require ACh to contract.
Cardiac muscle is under involuntary control and is myogenic, meaning that it does not require nervous system input to contract. Instead, specialized cells in the sinoatrial node spontaneously depolarize to produce electrical impulses that spread through the cardiac muscle via its intercalated discs.
During muscle contraction, the power stroke is the pivoting motion of the myosin head that pulls the actin filament inward to shorten the sarcomere. Given this, which of the following events immediately precedes the power stroke?
A.The binding of ATP to the myosin heads
B.The hydrolysis of myosin-bound ATP to ADP and Pi
C.The release of ADP and Pi from the myosin head
D.The binding of Ca2+ to tropomyosin
C.The release of ADP and Pi from the myosin head
In one of the four pathways, the transcription factor NF-kB is activated, which leads to increased expression of the proto-oncogene c-Fos.
A student isolates the cellular components of OPCs in wild-type (WT) mice and in mutant (MT) mice exhibiting a single base substitution that causes reduced osteoclast activity. Western blot analysis is then performed to test for NF-kB and c-Fos expression in the cytoplasm and nucleus of OPCs isolated from these mice. The results of this analysis are shown below.
Which statement best explains these results?
A.MT mice have a mutation that disables the ability of NF-kB to localize to the nucleus.
B.MT mice have a mutation that prevents c-Fos from interacting with NF-kB.
C.MT mice have a mutation in the DNA binding region of NF-kB.
D.MT mice have a mutation that prevents the transcription of c-Fos in OPCs.
A.MT mice have a mutation that disables the ability of NF-kB to localize to the nucleus.
Transcription factors are proteins that can alter gene expression by binding DNA near gene promoter regions to either increase or decrease the transcription of a target gene. Like all proteins, transcription factors are translated in the cytoplasm and must enter the nucleus (where DNA is stored) to influence gene expression. Transcription factors rely on their nuclear localization sequence to gain nuclear entry. The nuclear localization sequence is composed of amino acids and functions as a nuclear import tag that is recognized and bound by nuclear import proteins, which facilitate the transport of transcription factors into the nucleus.
Transcription factors contain DNA binding regions that allow them to interact with DNA in the nucleus. A mutation in the DNA binding region of NF-kB would prevent it from interacting with DNA and increasing the expression of c-Fos. However, a mutation in this region would notprevent NF-kB from entering the nucleus.