UWORLD 8 - CCS Flashcards

1
Q

Treatment of cystitis

Uncomplicated

Complicated

Pregnancy

A

Uncomplicated (normal non pregnant)

  • 3 day of TMP SMZ
  • if allergic do 3 day of fluoroquinolone (ex: ciprofloxacin)

Complicated (male, DM, anatomic, indwelling catherer, symptoms > 7 days, reurrent, >65)

  • 7 day TMP-SMZ

Cytitis in Pregnancy

  • 7 day course of Nitrofurantoin
  • If allergic, then 7 day of amoxicillin-calvulanate
  • Avoid TMP as it is a folic acid antagonist
  • avoid FQ due to caraliage damage
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cystitis and Diagnostic tests

A

B-HCG (qualitiative)

U/A

Urine Culture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Pregnant and uncomplicated cystits

therapy

monitoring

A

nitrofurantoin

prenatal vitamins

counseling

Monitoring - follow up urine culture in one to two weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

routine pre-natal laboratory tests in pregnancy

A

Atypical antibody

Blood Type & Rh

BMP

CBC

Chlamydia

HBV,

HIV

Pap-Smear

RPR, Rubella

Urine Culture,

U/A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Treatment & Follow up for Pregnant Patients

A

Treatment: Is For Pregnant Patients

  • Iron
  • Folate
  • Prenatal Vitamins
  • Prenatal Counseling

Follow up vist in 4 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Management of Ulcerative Colitis

Treatment of mild proctitis

A
  • Topical therapy with 5-ASA compounds (mesalamine suppository)
  • Taper over 4-6 weeks
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Management of UC:

Moderate proctitis

A
  • Oral thereapy with 5-ASA compounds (sulfasalzine, mesalamine, olsalzine)
  • Folic acid supplementation for patients taking sulfasalzine
  • Steriods are added with 5-ASA compounds fail to induce remission
  • Steriods should not be used for maintenance of remissions
  • Immunodulators (azathioprine, 6-MP) for refractory cases
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Mgmt of UC:

Severe proctitis

A
  • Hospitalize and resucitate with IV fluids & electrolytes
  • NPO, TPN
  • Abdominal exams, vitals and abdominal xray to monitor for complications
  • IV steriods
  • COnsider giving broad spectrum antibiotocisf or fever, luekocytosis or sepsis
  • Surgery is considered for refractory cases
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Other for Mgmt for UC

A
  • dietary counseling in all cases
  • annual surveillance colonoscoy beginning 8-10 years after diagnosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Diagnostic tests needed for UC

A

ESR

Sigmoidoscopy

Rectal Biopsy

*CBC with diff

*BMP

*Stool ova & parasites

*Stool for White cells

*Stool culture

*LFTs

*PT/INR

*PTT

*rule out alternative diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Managing diarrhea/cramps/mood for UC

A

Antidiarrhea agents (loperamide) for diarrhea (avoid in severe proctitis)

  • Anticholinergic agents for abd. cramps
  • Antiderpessants/anxiolytics for associated mood disorders
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Diagnostic tests needed for Ectopic pregnancy

A
  1. Beta-HCG, uine qualitative or Beta HCG serum
  2. Beta-HCG quantitative
  3. Transvaginal ultrasound
  4. Type and Cross matching
  5. Blood group & Rh
  6. CBC with diff
  7. PT/INR
  8. PTT
  9. BMP
  10. LFTs
  11. Gonoccoccal culture
  12. Chalmydia culture
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Therapy & Follow up for ectopic pregnancy

A
  1. MTX or laproscopy
  2. NPO
  3. IV access
  4. Normal saline, IV
  5. Bed rest, complete
  6. Morphone
  7. OB/GYN consult
  8. Counseling
  9. All Rh negative patients treated for ectopic pregnancy must receive Rh immunoglobulin
  10. Follow up in 4 days (if MTX is given to monintor serum HCG levels)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What do you need to monitor for Ectopic pregnancy

A
  1. Vital signs Q 1 hour
  2. If MTX is given, follow up in 4 days to monitor serum HCG level
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

IBS DIagnostic tests

A

IBS is a diagnosis of exclusion without a specfic confirmatory test

CBC with diff

BMP

FOBT

ESR

STOOL OVAL AND PARASITE

STOOL FOR WBC

STOOL FOR BACTERIAL CULTURE

72-HOUR STOOL FAT

PAP SMEAR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Therapy & Follow up for IBS

A

Lactose free diet

High fiber diet

Loperamide

Biofeedback

Reassurance

Relaxation exercise

Patient counseling

Schedule an appointment in two weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Diagnostic tests for Major Depression?

A

CBC with differential

BMP

TSH

Vitamin B12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Therapy & follow up for major depression

A

SSRI or other antidpressant

Medication compliance

Regular exercise

Patient education

FOLLOW UP: Every 1-2 weeks for the first 6-8 weeks of treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Diagnostic tests for Candidiasis

A

Vagina pH (<4.5 for Canidida and >4.5 for BV and Trich)

wet mount

Vaginal gram stain

Pap smear

GC culture

Chlamydial culture

UA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Therapy and follow up for Candida vaulvovaginitis

A

Anti-fungal (Miconazole, vaginal)

Counseling

  • patient education
  • Safe sex
  • No alcohol
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Diagnostic tests for Alzheimer’s dementia

A
  1. CBC with differential
  2. BMP
  3. LFTs
  4. TSH
  5. Vitamin B12, serum
  6. CT of the head or MRI of the head
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Therapy and follow up for Alzheimer’s dementia

A
  1. Cholinesterase inhibitor (Donepezil, oral, continous)
  2. Vitamin E
  3. Atypical antipsychotic (Olanzepine)
  4. Counseling

Follow up in 6 weeks.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Emergency orders (before Physicial examination) for COPD exacerbation

A

Elevate head of bed

Cardiac monitor

Pulse Ox

Oxygen

IV access

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Diagnostic tests for COPD exacerbation

A

PEFR (Q1 hour) (Peak Expiratory Flow Rate)

CXR, PA lateral

ABG

EKG

CBC

BMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Therapy for COPD Exacerbation
Bronchodilators (inhaled) - albuterol nebulizer, continous Steriods (IV methyl prednisone) Antibiotics (oral or IV) Counseling Influenza vaccine pneumococcal vaccine
26
Fibroadenoma Diagnostic tests
Mammography (not commonly used for women \<35) FNAB and/or Breast US Pap Smear
27
Therapy and follow up
Reassurance Counseling (patient counseling, contraception advise, safe sex, smoking cessation. limit alcohol intake, safety plan, seat belt use, regular exercise) Follow up physical exam every 3 to 6 months for 1 year
28
**Management of Hypertensive Emergency** Inital BP lowering management After 25% drop in BP is achieved Once BP is under control
**Inital BP lowering management** - If no evidence of stroke, lower DBP to 100-105 over 2-6 hours. Do NOT drop BP by more than 25% - IV nitroprusside (first line) - Alteratives (IV labetalol, nicardipine) - Transfer to ICU - Arterial line for BP measurement **After 25% drop in BP is achieved** **-** Transfer to ward - D/C arterial line - Change to PO anti-hypertensive **Once BP is under control** **-**Discharge to home - Lipid profile - Counseling (medication compliance, smoking cessation, exercise, limit alcohol intake, low salt diet)
29
Hypertensive Emergency - Emergency Orders
IV access Oxygen Pulse Ox Cardiac Monitor BP Monitor
30
Diagnostic tests for Hypertensive Emergency
12 Lead ECG Head CT (without contrast) CBC BMP CXR UA Llipid profile
31
Therapy for Hypertensive Emergency
1. NPO 2. Complete bed rest 3. IV antihypertensive (IV Nitropressuide, continous) 4. Counseling
32
Foreign body aspiration in 7 month old - emergency orders
Oxygen Pulse Oximetry IV access
33
Diagnostic tests for foreign body aspiration in 7 month old
1. CXR-PA/Lateral 2. X-ray Neck 3. CBC 4. Rigid bronchoscopy
34
Therapy and follow up
1. Bronchoscopy 2. Counseling Schedule appt in 1-2 weeks
35
Panic attacks Emergency Orders
IV access Pulse Ox Oxygen Cardiac Monitor ECG Glucometer Glucose
36
Diagnostic Tests for Panic Disorder
CBC BMP CXR TSH U/A Urine toxiciology screen Cardiac enzymes
37
Panic attack - therapy & Follow up
1) Benzodiazepines (Alprazolam, sublingual, one time) 2) Reassurance 3) Counseling (patient counseling, no caffeine, no nicotine, no alcohol) Follow up in two weeks
38
**Carotid Stenosis** Indications Contraindications Pharmcotherapy for Cartoid endarterectomy (CEA)
**Indications** - symptomatic with 70% to 99% stenosis - Greatest benefit if done within 14 days of the last symptomatic event **Contraindications** - 100% carotid stenosis - Previous stroke with persistent neurologic symptoms - Poor surgical candidate Pharmcotherapy with **aspirin** is indicated prior to the procedure and shoudld be continued **indefinitey**. **Clopidogrel** is an **acceptable** **alternative** in patients who are unable to tolerate aspirin. **-Warfarin and heparin are NOT INDICATED unless there is AFIB** **-Pre-ops antibotics** (Cefazolin, 1 gram, IV) recommended due to frequent use of prosthetic material **- Risk factor management (**HTN, DM, smoking, dysplipidedmia)
39
Cardioembolic Management
**Antithrombotic therapy for AFIB** **-Heparin use for acute TIA is controversial** - **Anticoagulate with warfari, dabigatran, apixaban, or rivaroxaban** is used for all patients who can tolerate anticoagution therapy - **use of direct thrombin inhibitor or a factor Xa inhibitor is preferred** to **warfarin,** unless there are cost or compliance concerns, the patient is already on warfarin, or there is signifcant renal failure (GFR \<30)
40
Diagnostic test for transient ischemic attack
Head CT (without contrast) CBC with diff BMP ECG Cardiac monitor Carotid Doppler Glucometer glucose Echocardiogram Lipid profile HBA1C MRI, head MRI, brain **Before CEA surgery** NPO PT/INR PTT
41
Therapy for Transient ischemic attack due to Carotid stenosis
IV access Aspirin CEA Cefazolin, IV one time Counseling (no smoking, no alcohol, regular excerise, diabetic diet, med compliance, better BP control, DM control)/
42
Diagnostic tests for PID suspicion
HCG, qualitative Gram stain, cervix Gonococcal culture Chlamydial culture UA Urine culture CBC BMP VDRL or RPR HIV Pap smear
43
Therapy for PID
**IV access** **Normal Saline** **Antibotics** _Inpatient_: IV cefoxitin, IV doxycycline _Outpatient_: Doxycycline, oral x 14 days **Antimetics** **Analgesics** (IV morphine, one time) **Antipyretics** (Acetaminophen, IV) **NPO** **Bedrest** *\*Do not wait for culture results to initate empiric antibiotics against N.gonorrha and C.trachomatis*
44
**Prolonged PTT with normal PT** may be due to a number of hereditary or acquired conditions inolving **which coagulation pathway?** ## Footnote **Inherited causes include?** **Acquired causes?**
**Intrinsic coagulation pathway** _Inherited causes_ Factor VIII (hemophilia A) Factor IX (hemophilia B) Factor XI Von Williebrand disease _Acquired causes_ Antiphospholipid syndrome Heparin use
45
Diagnostic tests for suspected Hemophilia A
CBC with differential BMP Bleeding Time PT PTT LFT Factor VIII, plasma Factor IX, plasma Factor XI, plasma
46
Therapy for Hemophilia A
Factor VIII, therapy No aspirin Counseling Consult, genetics \*Monitor PTT value
47
Emergency orders for chest pain
pulse oximetry oxygen cardiac monitor continous BP monitor 12 lead ECG IV access ASA Nitroglycerine \*MUST ORDER THESE BEFORE PHYSICAL EXAM
48
Diagnostic tests that need to be order for chest pain
12 lead ECG Cardiac enzymes CXR CBC BMP LFT Lipid profile PT/INR and PTT Echocardiography Cardiology consult Cardiac catherization
49
Therapy for chest pain
IV access Oxygen Aspirin Nitroglycerine Hepatrin Metoprolol Eptifibatide (GP IIB/IIIA inhibitor should be added before sendin gpatient for catherization) Simvastatin Cardiology consult Cardiac catherization NPO Bed rest Counseling
50
**Management of viral coup** Mild coup moderate to severe symptoms In all cases
**Mild (barking cough, no stridor at rest, no retractions)** - cool humidified mist and oxygen (relieves airway edema and decreases viscosity of mucus) - monitor for development of bronchospasm in suspectible children - oral dexamethasone **Moderate-severe symptoms (stridor at rest, moderate-severe retractions, anxious/agitated)** - add nebulized epinephrine - if no improvement, admit **In all cases** - if bacterial infection is suspected, add antibiotics (2nd generation cephalosporin) - arrange outpatient follow up
51
Emergency orders for viral coup
oxygen pulse oximetry
52
Diagnostic tests for viral coup
CBC Neck Xray BMP
53
Therapy for viral coup
humidified air epinephrine (inhaled) dexamethasone (oral) counsel patient
54
**_Asthma management_** **If impending respiratory arrest is suspected, then?**
**If impending respiratory arrest is suspected, then?** **-** Intubate, mechanically ventilate and admit to ICU - Administer nebulized albuterol/ipratropium - Administer systemic steriods
55
**_Asthma management_** If there is not suspiction of impending respiratory arrest, then? Decision to admit?
**PEFR \<40% predicted:** - Administer oxygen therapy with goal pulse ox \>=90% - Administer albuterol/ipratropium by nebulizer (q20 min) - IV steriods (then gradully taper) - Reassess PEFR every hour - Decision to admit within 4 hours **PEFR \>40% predicted:** - administer oxygen therapy with goal pulse ox\> or -90% - administer albuterol by nebulizer (q20mins) - consider oral steriods (gradually taper if initated) - If PEFR does not improve to \>70% predicted, then add ipratropium - decisiton to admit within 4 hours. **Decision to admit** - Admit for PEFR \<40% predicted at 4 hours - Consider admission for PEFR 40-70% at 4 hours - Discharge to home for PEFR \>70% at 4 hours
56
Emergency orders for asthma exacerbation
Pulse oximetry oxygen IV access Head elevation Cardiac monitor
57
Diagnostic tests for asthma exacerbation
Peak flow (PEFR) ABG ECG CXR CBC BMP
58
Therapy for mild to moderate asthma exacerbation
Oxygen albuterol, nebulizer Iptratropium bromide (nebulizer, continuous) Steriods counseling
59
Diagnostic tests for chronic constipation
CBC with diff BMP Serum magnesium Serum phosphate TSH FOBT Colonoscopy HBA1C
60
Therapy for chronic constipation
High fiber diet Metamucil (psyllium) oral hydration low salt diet low fat diet exercise program patient counseling
61
Appendicitis diagnostic tests
CBC with differential BMP LFT FOBT Abdominal xray Abdominal US UA PT/INR PTT
62
Therapy for appendicitis
NPO IV access IV Normal saline IV analgesia (morphine) IV antiemetics IV cefoxitin Surgery consulut Laproscopy
63
Diagostic tests for septic arthritis?
CBC with diff BMP Blood cultures PT/INRPTT X-ray of the Knee Synovial fluid analaysis Synovial fluid gram stain & culture
64
Therapy for septic arthritis
**IV access IV NSS 0.9%** **Acetaminophen, oral, continuous** **NPO** **IV analgesia** (Morphine, IV, one time) **IV antibotics Ortopedic consult** **Arthroscopy** (when there is failure to adequately drain the knee joint with joint aspiration) **Counseling**
65
What is the inital antibotic therapy while waiting for gram stain results?
**Broad spectrum coverage** IV 3rd generation cephalosporin (ceftriaxone, ceftazidmine, cefotaxime) with IV vancomycin.
66
**Adjust antibiotic regimen when gram stain results are obtained:** Gram stain shows gram-positive cocci Gram stain shows gram-negative bacilli
**_Gram stain shows gram-positive cocci_** _MRSA_: IV Vancomycin x 4-6 weeks _MSSA_: IV nafcillin or IV cefazolin for 2 weeks then 2-4 more weeks of oral antibiotics ***\*Staph aureus is the most common cause of non-gonococcal arthritis in adults*** **_Gram stain shows gram-negative bacilli_** IV 3rd geeneration cephalosporin (ceftriaxone x 14 days), then 14 days oral antibiotics
67
Diagnostic tests for Dysfunctional Uterine Bleeding
Qualitive urine HCG Serum TSH Serum Prolactin CBC with differential PT/INR PTT
68
Once Dysfunctional Uterine Bleeding is confirmed, what is the treament for Mild DUB Moderate DUB Severe DUB
_Mild DUB (normal Hgb)_ **Iron supplementation alone is sufficient** _Moderate DUB (Hgb = 10-12)_ **Iron supplementation** **Progestin-only OCP (preferred in absence of active bleeding)** **Combination OCP (preferred in presence of active bleeding)** _Severe DUB (Hgb\<10)_ **Depending on severity, hospitalization, transfusion as needed** **Hormonal therapy: Combination OCPs with high estrogen if stable; IV estrogen if unstable** (D&C and/or surgery are rarely necessary)
69
Therapy for moderate DUB
OCP Iron sulfate Reassurance Counseling - Med. compliance - safe sex - regular exercise - seat belt use
70
Emergency orders for suspected pericardits
Pulse Ox Oxygen Cardiac monitior BP monitor 12 lead ECG IV access
71
Diagnostic tests for pericarditis
CBC with differenital BMP Chest x-ray CK-MB Troponin I ESR BLood cultures Echocardiography
72
Therapy for pericarditis
NSAIDs Colchicine Reassurance Counseling
73
**Management of Blunt abdominal trauma:** Stable, alert and non-intoxicated Unstable, unconscious or intoxicated
_Stable, alert and non-intoxicated_ - proceed with **abdominal CT with contrast** - If **no intradominal injury**, just **observe** and perform serial exams - If **intrabdominal injury +/- hemoperitoneum**, **hospitalize** and consider conservative management or immediate lapartomy, depending on the extend of injury and the quantity of blood loss _Unstable, unconscious or intoxicated_ - proceed with **abdominal US** - If there is **no intraperitoenal hemorrhage**, perform **abdominal CT**; then manage as above - If there **is intraperitoneal hemorrhage,** perform **immediate** **lapraotomy**. Surgery consult should be obtained in all cases.
74
Emergency orders before phyical examination for Blunt abdominal trauma
C-spine immobilization IV access IV NSS 0.9% Pulse Oximetry Oxygen BP Monitor Cardiac Monitor *\*Cervical spine immobilization should be performed before the physical exam*
75
Diagnostic test for BAT
CBC with diff BMP LFT Serum Amylase Serum Lipase UA ABG PT/INR PTT Blood type & crossmatch Blood ethanol Urine toxicology screen Urine Qualitative HCG 12 lead ECG Spine Xray CXR Abdominal Ct Urine output \*Surgery ocnsult should be obtained immediately following the exam
76
THerapy for BAT
NPO General Surgery consult Foley catheter IV analgesia IV anti-emetics Cousneling - Avoid contact sport - no alcohol - no smoking - seat belt use \*\*Surgery ocnsult should be obtained immediately following the exam
77
Management of cellulitis
_Mild:_ - **No diagnostic investigations** - **Outpatient empiric antibotics** - If **purulent cellulitis** (purlent drainage or exudate, no drainable abscess), **MRSA** is suspected - **Clindamycin, TMP-SMX (Bactrim), Doxycycline or Linezolid** - If **nonpurlent** **cellulitis** (no purlent drainage, exudate, or abscess), beging empiric coverage for **beta-hemolytic streptocci and MSSA**- **Clinidamycin, Amoxiccillin + TMP-SMX, Amoxicllin+Doxyclicline, or Linezolid** _Severe: Systemic toxicity, extensive skin involvement, or failure of the inital antibiotics regimen_ - **Hospitalize** - **Limited diagnostic work-up** to rule out alternative diagnosies (xray of the affected extremity, CBC, BMP, blood cultures) - **Parenteral antibiotics with IV vancomycin** (until MRSA is ruled out) or clinidamycin; **switch to oral antibiotics upon clinical improvement** * \*Supportive therapy (leg elevation and heydration) in all cases; treatment of underlying conditions if present*
78
Managemen of acute gouty arthritis what is the DOC if there are no contraindications present? What if they are contraindicated? What if they can tolerate both above? What is used for prevention of recurrent gout?
**NSAIDS** **(naptroxen, indomethacin) a**re the drugs of choice for acute gouty arthritis **if no contraindications** (renal failure, heart failure, PUD, NSAID allergy) are present If NSAIDS are contraindicated, **use intraarticular or oral steriods** If NSAIDs and Steriods cannt be given, **administer cholchicine,** but be aware of the **high incidence of side effects** (diarrhea, abdominal cramps, N&V). **Allopurinol** should not be presecribed in acute gouty arthritis because it may worsen the acute attack. It is primarily used for **prevention of recurrent gout.**
79
What should be advised to all patients with gout?
Avoid aspirin & diuretics (if possible), excessive amoutn of alcohol and purine rich food. For overweight and obese patients, recommend weight loss through diet and exercise.
80
Diagnostic tests for acute gouty arthritis?
CBC with diff BMP PT/INR PTT ESR Serum Uric Acid Xray of the foot/toes Synoval fluid analysis
81
Diagnositc test in a stable patient with suspected PCP
Pulse Oximetry CBC with diff BMP ABG Serum LDH Sputum PCP stain CXR Blood G6PD (in anticipation of the potential need of dapsone or primaquine) HIV test by ELIZA HIV test by West. blot CD4 count HIV viral load
82
Therapy of a stable PCP patient
TMP-SMZ Glucocorticoids Oxygen Influneza vaccine Pneumococcal vaccine Start HAART (Efavirenz/Tenofovir/Emtricitable) Counseling - Medication compliance - no alcohol - safe sex - HIV support group - Patient counseling ***\*Must add steriods if P02 \<70 or A-a gradient is \>35 mm Hg***
83
Suppect RCC when any of the following are present? What is ordered for suspected RCC?
Unexplained hematuria Flank pain Palpable flank mass Order Abdominal CT (provides presumptive diagnosis, provides staging info)
84
If abdominal CT provides presuptive diagnosis of RCC, then:
- **Obtain CT chest** for further staging info - **Bone** **scan** if there is **bone pain or elevated alkaline phosphatase** _Determine stage based on abmoninal CT/chest Ct/+/- bones scan_ - **Nephretcomy** is prefered for **isolated renal mass (**diagnostic and therapeutic) - **Biopsy** preferred for **suspected metastic dz**; further treatment dictated by result
85
Diagnostic tests for suspected RCC
CBC BMP LFT UA FOBT Abdominal CT Chest CT Serum Iron TIBC Ferritin PT PTT/INR BLood type and cross match
86
Therapy for RCC (isolated mass)
NPO Oncology consult Surgery consult PT PTT/INR blood type & Cross match IV cefazolin Nephrotomy Counseling - No smoking - No alcohol - Cancer diagnosis **\*Must remember to order nephretcomy**
87
Emergency orders for suspected perforated peptic ulcer
Pulse Ox IV access BP monitor Oxygen 12 lead EKG Cardiac monitor
88
Diagnostic tests for perforated duodenal ulcer
CBC with differential BMP LFT serum lipase Serum amylase Abominal or CXR PT/INR PTT Type and cross match
89
Therapy for perforated duodenal ulcer
Bedrest NPO NG tube IV NSS IV analgesia (morphine) IV antiemetics IV antisecretory drug (PPI) IV antibotics (ampicilin--sulbactam) Surgery consult Lapartomy/laparoscopy Counseling - No smoking - patient counseling
90
Diagnostic tests for Turners syndrome
Karoytpe analysis Serum FSH Serum LH Serum TSH BMP Fasting glucose Lipid profile Renal US Pelvic US Echocardiography Skeletal survey Hearing test
91
Therapy for Turner's syndrome
Growh hormone therapy Estrogen progesterone therapy Vitamin D Calcium Dietary consult Psychiatry consult (estimate IQ) Opthalmology consult Counseling - reglar diet - regular exercise - medication compliance - parent counseling
92
Goal of hypertensive therapy
Goal BP \<140/90 for age \<60; CKD, DM Goal BP is \<150/90 for \> or = 60
93
**Prefferd drug in the presence of comorbidities:** Afib/Aflutter Angina pectoris MI CHF DM (no proteinuria) Proteinuria Osteoporosis BPH
_Afib/Aflutter (rate control)_ - **BB, Non-dihydroyrine CCB** _Angina pectoris_ - **BB, CCB** _MI_ - **ACE I/ARB, BB, or aldosterone antagonist** _CHF_ - **ACE I/ARB, BB, diuretic, or aldosterone antagonist** _DM (no proteinuria)_ - **Diuretic or ACE I** _Proteinuria_ - **ACE I or ARB** _Osteoporosis_ - **Thiazide diuretic** _BPH_ - **Alpha-blocker (Prazosin, Terazosin, or Doxazosin)**
94
What must you remember in patients with HTN?
make sure to repeat BP readings at least two more times over a period of weeks to months.
95
Diagnostic tests for essential HTN
CBC BMP UA Lipid profile 12-lead ECG
96
Therapy for essential HTN
**Life sytle modificaitons** - low salt diet - regular exercise - no smoking - no alsochol - calorie restricted diet - low fat diet **Oral antihypertensives**
97
Diagnostic tests for acute diverticulitis
CBC with diff BMP LFT UA Abdominal CT Blood culture
98
Therapy for acute diverticulitis
NPO IV access IV NSS 0.9% IV analgesia IV antiemetics (Phenergan) IV ampicillin-sulbactum Advance diet/clear liquids Counseling - High fiber diet - Medication compliance - Medication side effects - Regular excercise ***\*Empiric antibiotics and bowel rest should be initated immediately following the physical exam***
99
Diagnostic tests for child abuse
Pulse ox CBC with diff PT PTT/INR Bleeding time CXR
100
Therapy for child abuse
Analgesia (Nsaids or narcotics) chest physiotherapy Incentive spirometry Child protective service consult Psychiatric consult Regular diet Counsel parent ***\*Must promptly report suspicion of child abuse to child protective services***
101
Diagnostic tests for menopause
**None** Menopause is a clinical diagnosis, defined by 12 months of ammenorrhea in a women over 45 years of age, in the absence of an alternative explanation.
102
Therapy for menopause
**Estrogen-progesterone therapy** **Counseling** - regular exercise - high calcium diet - low salt diet - medication compliance - medication side effects - HRT
103
Outpatient managment of DVT
**Simple DVT** is often managed on an **outpatient** basis. Choices for **anticoagulant** therapy includes **LMWH (enoxparin) plus warfarn** or fondaparinux plus wafarin. **Enoxparin (lovenox) i**s the most commonly used LMWH. Coagulation monitoring is unnecessary for LMWH, but the **platelet count should be obtained on day 3 and 5 because of the risk of HIT.** **Warfarin is begun within 24 hours of heparin initation.** **Heparin is distoninuted after 5 days** if the **INR** has been **therapeutic** (INR =2-3) for 24-48 hours. **Stop heparin if platelet count drops under 100.000 or is reduced by \>50%**
104
Inpatient management of DVT
Commonly used anticoagulant therapy is **unfractionated heparin (UFH) plus warfarin or LMWH plus warfarin.** In addition to monitoring the platelet count (as outline in outpatiet management), **PTT should also be monitored while on UFH**, with a **therapetic PTT goal of 60-80.**
105
Deep vein thrombosis diagnostic tests
CBC BMP D-dimer Lower extremity doppler US ***\*Must not delay diagnosis caused by failure to order US***
106
Therapy for DVT
Heparin or fondaparinux Warfarin Bed rest Counseling - medication compiance - medication side effects - no smoking
107
What must you monitor on heparin therapy
INR (goal 2-3) Platelet count on day 3 and 5 PTT if UFH is used
108
How do you determine PE probability? Management if probablity is low versus high? What provides a definitive diagnosis? What do you do whie pending test results? Management of the following: - Postive CT/High probabilty scan: - Negative CT/Low probabily scan: - Inconclusive CT/Intermediate scan:
Based on modified **Well's score** **PE unlikely** if Well's score \< or = 4, obtain **D-Dimer,** and proceed to **CT-PA or V/Q if D-dimer \>500.** **PE likely** (score \>4), proceed directly to **CT or V/Q** **Spiral CT pulmonary angiography (CT-PA) or V/Q scan provide definitive diagnosis** **Empirically start hepatrin/fondaparinux pending test results** - _Postive CT/High probabilty scan_: continue with therapy - _Negative CT/Low probabily scan_: discontinue heparin - _Inconclusive CT/Intermediate scan_: Order **pulmonary angiogram or serial lsower extremeity doppler**; presence of DVT or Positive pulmonary anigogram warrants treatment. **Pulmonary anigogram is the gold standard, but is only used if spiral CT or V/Q scan are inconclusive.**
109
Commonly used Anticoagulant therapy for Pulmonary embolism What is preferred in hemodynamicaly stable patients without renal failure? What about those with renal failure?
LMWH + Warfarin, UFH + Warfarin, or Fondaparinux + Warfarin **SC LMWH i**s preferred in hemodynamicaly **stable patients without renal failure**, while **IV UFH** is preferred in cases of hemodynamic **instability**, **advanced renal failure, high risk of bleed and in anticipating for thrombolytic therapy.**
110
Emergency orders for patient suspected of PE
Pulse oxidmetry Oxygen IV access ECG Cardiac monitor
111
Diagnostic tests for PE
D-dimer Cardiac enzymes CBC BMP CXR ABG Spiral chest CT or V/Q scan \*Delay in diagnosis caused by failure to order d-dimer, spiral CT-PA or V/Q scan
112
Therapy for PE
DIscontinue OCP LMWH/UFH/Fondaparinux Warfarin Counseling - no smoking - medication compliance - medication side effects \*Do not delay treatment with heparin or fondaparinux \*Fialure to add warfarin to heparin or fondaparinux
113
DIagnostic tests for suspected colon cancer
CBC BMP LFTs Colonoscopy Abdominal CT CXR CEA UA ECG PT PTT/INR Blood type & cross match
114
Therapy for colon cancer
NPO Pre-colonscopic MBP Polyethyelen glycol Pre-op antiotics hemicolectomy Oncology consult Surgery consult Counseling - cancer diagnosis - no smoking - no alcohol
115
Orders for patietn suspected of bipolar I disorder, acute manic episode
CBC with diff BMP TSH Urine toxicology screen
116
Therapy for patient with bipolar I disorder, acute manic episode
Antipsychotic or BZD Mood stabilizer Psychiatry consultation Psychotherapy Counseling - Medicaiton compliance - medication side effects - suicide contract - regular exercise - patient education \*do not delay in treatment with antipsychotc or benzo \*Do not fail to add mood stabilizer
117
CSF findings suggestive of bacterial mengingitis include
turbid appearance WBC \>1000 PMN predominance Glucose \<45 protein \>250
118
Early empiric antibiotic therapy pending CSF gram stain for suspicion of bacterial meningitis Adjust antibiotic rigment when gram stain results are available. - Gram postive cocci - Gram negative cocci - Gram positive bacilli - Gram negative bacilli
_Early empiric antibiotic therapy_ Broad spectrum coverage against major pathogens of bacterial mengitis: **IV 3rd generation cephalosporin** (ceftriaxone, cefotaxime, ceftazidime) **plus IV vancomycin** **Ampillicin** is added to this regimen if the patient is immunocompromised _Gram postive cocci_ *(Strep pneumo, mcc of acute bacterial mengigitis in adults)* **- continue with above therapy** _Gram negative cocci *(*_*Neisseria)* **- IV 3rd generation cephalosporin (ceftriaxone, cefotaxime)** _Gram positive bacilli *(Listeria)*_ **- IV ampillicn plus IV gentamycin** _Gram negative bacilli_ (Enterobacteriaceae) **-IV 3rd generation cephalosporin (ceftriaxone, cefotazime, ceftazidime) plus IV gentamycin**
119
Diangostic tests in stable patient with suspected bacterial menigitidis
CBC with diff UA BMP CXR Blood culture Lumbar puncture CSF cell count CSF glucose CSF protein CSF gram stain CSF bacterial antigen CSF culture Head CT \*Delay in diagnosis caused by failure to order CSF analysis
120
Therapy for bacterial mengititis
NPO Head elevation Complete bedresst IV access IV NSS 0.9 IV antibitoics IV dexamethasone IV antiemetics Anitpyretics Patient counseling \*Delay in treatment with parenteral antibitoics \*Failure to order steriods in pneumoccal mengitis.
121
**Management of Cryptococcal meningitis** Pharmacotherapy (acute and maintenance) Management of ICP
**_Pharmacotherapy (acute and maintenance)_** -_Acute_: **IV ampthotericin B plus oral flucotosine for 14 days** (alt. is fluconazole plus flucytosine). This regiment is discontinued if clinical improvement is noted. **Afterward**, it is followed by **consolidation therapy** with **fluconazole** 400 mg/d for **8-10 weeks**.. **HAART can be initated at the end of acute treatment.** **Maintenance therapy: Fluconazole 200 mg** is the preferred drug; consider itraconazole if patient is allergic to fluconazole. **Discountinue maintenance therapy in asymptomatic patients with CD4\>100** for 1 year. Reinstitue maintenace therapy if CD4 \<100. **_Management of ICP:_** - **Repeat LP daily** until OP \<200 mm H20 or \> 50% reduction - If high ICP persists despite daily LP, consider **lumbar drain or ventricular shunt.**
122
Findings suggestive of AIDs-related CNS cyrptococcosis
Lymphopenia and monocytosis on CBC postive HIV by ELIZA High opening pressure during LP CSF analysis shows mononuclear pleocytosis, slightly elevated protenin, presence of encapsulated yeast on India ink stain and postive CrAg.
123
Diagnostic tests for suspected cryptococcal meningitis
CBC with differenital BMP Head CT/MRI Lumbar puncture CSF cell count CSF glucose CSF protein CSF gram stain CSF bacterial antigen CSF culture CSF CrAg CSF India ink stain CSF fungal culture CSF AFB Serum CrAg HIV by ELISA Blood Culture ***\*Delay in diagnosis cuased by failure to order CSF CrAg, CSF India ink stain, or CSF fungal culture***
124
Therapy for Crytococcal meningitis
**IV access** **Antifungals** - first IV amphotercin B, IV, continous & Flucoytosine, oral, continous - then discontinue after two weeks and start fluconazole, oral, continous **Counseling** - medication compliance - no smoking - no alcohol - safe sex- HIV support group
125
Suspect herpes encephalitis if any of the following are present?
- Febrile encephalopathic patient with focal neuroloica deficits on the physical exam - CSF analysis revealing lymphotocytic pelocytosis, elevated protein, elevated RBCs but normal glucose - Temporal lobe abnormaltiies on CT/MRI
126
Management of Herpes Encephalitis
**Early empiric antiviral therapy with IV acyclovir** (pending PCR results) is recommended to avoid neurologic sequelae or death. Patient should be treated for **14-21 days.** - **Hydration with NSS** should be given to avoid acyclovir-induced kidney injury from crystal formation - **Adjust acyclovir dose in patietns with kidney failure**
127
Diagnsotic tests for suspected Herpes simplex encephalitis
CBC with diff UA BMP CXR Blood culture Urine culture Lumbar puncture CSF cell count CSF glucose CSF protein CSF gram stain CSF bacterial antigen CSF PCR for HSV CSF culture PIT/INR PTT Head CT/MRI ***\*delay in diagnosis cuased by failure to order PCR of CSF for HSV***
128
Therapy for herpes encephalitis
NPO Head elevation Complete bedrest IV access IV NSS 0.9% IV acyclovir IV antiemetics Patient counseling
129
Diagnostic criteria for temporal arteritis
include the presence of at least 3 of the following 5: - age \>50 - new onset headache - temporal artery tenderness or decreased pulsations - elevated ESR (\>50) and/or CRP - Biopsy showing necrotizing vasculitis or granulomas Additional amnifestations may include fever, fatigue, weight loss, jaw claudification, visual disturbances and symptoms of PMR
130
Management for temporal arteritis
**_Uncomplicated temporal arteritis (can be managed as an outpatient)_** -_Acute therapy_: Begin with a **high dose oral steriod** (40-60 mg/day of prednisone) until clinical response is noted. Then, **slowly decrease steriod dose to 10 mg/day.** -_Maintenance therapy_: Once predinisone of 10 mg/day is achiveved, gradually taper predinisone in 1 mg decrements over a period of at least 9 months. **_Complicated (ex: vision loss)_** - acutely **initate IV steriods** (dexamethasone or methylprednisolone) for **three days**, and then **switch to oral steriods** as above. In all cases, **prophylactic therapy for gastroduodenal protection** with misoprostol, H2 blocker or PPI is indicated. **Prophylactic osteoporosis** prevention with clacium plus vitamin D is also indicated. **Baseline DEXA** scan should be obtained to assess the need for bispohosphonates.
131
Diagnostic tests suspected temporal (giant cell) arteritis
CBC with differential ESR BMP UA Urine Culture Blood Culture Head CT CXR Temp. artery biopsy ***\*Delay in diagnosis cuased by failure to order temporal artery biopsy***
132
Therapy for temporal (giant cell) arteritis
Biopsy, temporal artery, routine Prendisone, oral continous Aspirin, oral, continous Pantoproazole, oral, continous Calcium, oral, continous Vitamin D, oral, continous Counseling - patient counseling - medication compliance ***\*Delay in treatment with steriods***
133
PMR is a clinical diagnosis based on the following criteria
Age \> 50 Bilateral pain and morning stiffness (lasting \> 30 mins) for more than a month and involving the shoulders, neck, hips or torso ESR \> 40 mm/hr or ESR \< 40 mm/hr plus elevated CRP Rapid response to steriods, usually within 3 days Exclusion of alternative diagnoses
134
Therapy of PMR
Steriods are the mainstay of therapy Prompt resposne to **low dose steroids** is typical of PMR. Inital steriod dose is **maintained for two to four weeks** after symptoms resolution. Then it is **gradually tapered every two to four weeks** to the lowest dose that is needed to suppress the patient's symptoms and maintated at this level for one to two years. **Prophylactic therapy** with misoprostal, H2-blocker, or PPI is indicated for **gastroduodenal protection.** In addtion, calcium and vitamin D are recommended for **osteoporosis prevention.** **Baseline DEXA** scan should be ordered to assess the need for bisphosophonates.
135
Diagnostic tests for PMR
CBC with differential BMP ESR CRP RF ANA Serum TSH SErum CPK CXR ***\*Delay in diagnosis caused by failure to order ESR and additonal lab testrs to rule out alternative diagnoses.***
136
Therapy for PMR
Prednisone, oral, continuous Calcium, oral, continous, Vitamin D, oral, continuous Counseling - Patient counseling - Medication compliance
137
Diagnostic tests for simple ovarian cyst with torsion
CBC with diff BMP UA Pregnancy test Pelvic US PT/INR PTT \**Delay in diagnosis caused by failure to order pelvic US* *\*\*Failure to rule out pregnancy by not ordering HCG*
138
Therapy for simple ovarian cyst with torsion
IV access IV NSS 0.9% IV antiemetics IV analgesics NPO Bedrest Gynecology consult Laproscopy/Laparotomy Counseling *\*Delaying surgical intervention*
139
Diagnostic tests for ovarian cancer
CBC with differential BMP LFT UA Pelvic US colonosocpy Mammogram Pap smear Abdominal/pelvic CT CA 125 CXR ECG PTT PT/INR * \*Delay in diagnosis caused by failure to order pelvic US/CT* * \*\*Failure to request preoperative orders: CBC, BMP, LFT, UA, FOBT/Colonoscopy, mammogram, pap smear, CXR, ECG, PTT, PT/INR and CA 125*
140
Therapy for ovarian cancer
NPO Gynecology consult IV cefazolin DVT prophylaxis Laparotomy Oncology consult Counseling - cancer diagnosis - no smoking - no alcohol
141
Diagnostic tests for sigmoid volvulus
CBC with differential BMP Abdominal x-ray UA *\*Delay in diagnosis caused by failure to order abdominal x-ray*
142
Therapy for sigmoid volvulus
NPO IV access IV D5NS or D5-1/2 NS with KCL NG tube IV analgesics Gastroenterology consult Sigmoidoscopy Counseling *\*Failure to order, sigmoidsocopy, colonoscopy or rectal tube placement*
143
Diagnostic tests for Acute cholecystits
CBC with differential BMP LFT BLood cultures Adominal x-ray Abdominal US PTT PT/INR *\*Delay in diagnosis caused by failure to order CBC and adominal US*
144
Therapy of acute cholecystitis
NPO NG tube IV access IV D5-1/2NS or NS Analgestics (ex: ketorolac) IV antiemetics IV antibiotics Bed rest with BRP Surgery consult Laparoscopy/laparotomy Cousneling * \*delay in initating appoproiate empiric antibiotics* * \*\*failure to request cholecystectomy by laparoscopy or laparotomy*
145
Therapy for acute bacterial rhinosinusitis
**Empiric antibiotic therapy for 5-7 days** is recommended. **Oral amoxicillin-clavulanate is the drug of choice.** If **PCN allergy** is present, consider **doxycycline** **or respiratory fluoroquinolones** (levofloxacin or moxifloxacin) Supportive therapy include analgesics, nasal saline irrigation, topical glucocorticoids, and adequate hydration.
146
Diagnostic tests for acute bacterial rhinosinusitis
None
147
Management of suspected AAA rupture
**_Emergency orders:_** IV access, IV fluids and BP monitor Proceed according to the patient's hemodynamic status **_Unstable (SBP \< 90 mm Hg)_** consult vascular surgery immediately surgical intervention without delay **_Stable (SBP \>90 and talking)_** urgent confirmatory test: urgent abdominal US or CT Consult vascular surgery surgical intervention *\*Pre-operative orders (CBC, MBP, PTT/PT/INR, blood type and cross match, IV cefazolin and NPO) should be requested, although the restults may not be obtained before surgery*
148
149
Emergency orders for suspected ruptured AAA
IV access BP monitor Cardiac monitor ECG Pulse Ox Oxygen
150
Diagnostic tests for suspected ruptured AAA
CBC with diff BMP PT/INR PTT Abdominal US/CT
151
Therapy for ruptured AAA
discontinue metoprolol discountine aspirin NPO Bed rest IV fluids IV analgesics IV antiemetics Type and cross match Vascular surgery consult IV cefazolin Aneurysmectomy Counseling
152
Diagnostic tests for intussception
CBC with differential BMP Abdomnal x-ray Adominal US *\*delay in diagnosis caused by failure to order adominal US*
153
Therapy for intussception
NPO NG Tube IV access IV fluids IV analgesics IV antiemetics Surgery consult Constrast Enema Counseling * \*Failutre to decompress the stomach with NG tube* * \*Delay in reduction with constrast enema* * \*requesting laparotomy for uncomplicated intussception*
154
Stat orders for DKA
Pulse ox, stat and continuous Oxygen, inhalation, continuous IV access, stat Cardiac monitor, stat Normal saline, 0.9 Nacl, continous, stat Finger stick glucose, stat
155
Orders for DKA
Urine pregnancy test, stat CBC with differential, stat BMP, stat Calcium, serum, stat EKG, 12 lead, stat serum amylase, stat serum lipase, stat UA, stat ABG, stat Serum osmolality, stat Serum ketones, qualitative, stat Reguarlar insulin, IV, continuous, Phenergan, IV, one time (for nausea) Discontinue oxygen
156
DKA - Review orders
Admit patient to the ICU NPO Ved rest Vitals as per ICU protocol Urine outpout KCL, iV, continuous HbA1C level, routine Phosphorous, serum, stat (optional) Follow the patient with 1. BMP Q2-4 hours, then Q8-12 hours, then Q day 2. ABG Q2 hours x 2 days After 4 hours: 1. stop 0.9 NS and give 1/2 NS saline, IV continus Monitor potassium deficiency, add IV potassium chloride as needed Consider antibiotics if the preciptiating cause is an infection, get CXR, obtain blood cuylutres, UA and urine cultures Once nausea is decreased, start oral fluids Onc ethe patient is stabilized transfer to ward/floor
157
During discharge of DKA
D/C IV insulin, IV fluids, cardiac monitor NPH insulin, subcutaneous, continous Regular insulin, subcutaneous, continuous Diabetic diet Advance diet
158
Counseling for DKA
Diabetic teaching Patient education, diabetes Diabetic food care Home glucose monitoring, instructe patient No alscohol No smoking Safe sex No illegal drug use Regular excerise seat belt use \*follow up appointment in 10 days
159
28 year old white female is brought into ER in unconscious state
**Emergency management: hemodynamicaly unstable, so A, B, C, D** A: **airway suction, pulse ox, stat and coninous monitoring, O2** B: **Endotracheal intubation** is indicated in patietns who cannot protect their airway or if O2 saturation does not improve with O2 nasal/face mask, or PaO2 \<55 or PCO\>50 on ABG C: **IV access, cardiac monitor, place a foley, obtain finger stick glucose** D: drugs: **Administer thiamine, dextrose 50% and naloxone - all are IV bolus one time dose**
160
Emergency Orders for uncouscious state
Suction airway, stat pulse ox, stat and continous oxygen, inhalation, stat and intubation IV access, stat cardiac monitor, continous finger stick glucose, stat thiamine, IV stat, one time Dextrose 50%, IV stat, one time NS 0.9 NaCl, stat, continous, ABG, stat
161
Orders for Possible narcotic overdose
EKG 12 lead, stat CBC with diff, stat BMP, stat CXR, portable, PA stat LFTs, stat UA, stat Urine toxicology screen, stat B-HCG, serum, qualiative, stat Blood alcohol stat
162
Inital treatment with possible narcotic overdose
NG tube, gastric lavage, stat Activated charcol, oral, one time Naoloxone, IV, stat, continous
163
For narcotic over, after treatment
Decison about chaging patient lcoation move patient to ICU NPO bed rest, complete urine output, BMP, next eday Once the patietn is better, D/C oxygen, NG tube, cardiac monitor, IV fluids and naloxone Regular diet
164
Narcotic overdose - counseling
psychiatry consult (stat (reason: suicide attemp) sucide precaustions suicide contract patient cousneling reassurance no acohol no smoking safe sex no illegal drug use reguar exercsie seat blet use \* start patient on antidepression if neeeded
165
Emergency orders for acute exacerbation of heart failure
elevate head of bed pulse ox, stat and continuous oxygen, inhalation and continuous IV access, stat Cardiac monitor 12-lead ECG, stat
166
Order for suspected acute excerbation of heart failure
CXR, PA and lateral views, stat CBC with diff, stat BMP, stat Troponin I, stat and Q6 hours x 2 LFTs, stat NT-proBNP, stat Furosemide (lasix) IV, stat and continous
167
Patient with suspected acute excerabation of heart failure CXR is consistent with b/l pulonary edema. CBC with differential and troponin I are normal BMP shows Na 138 and K 4.0 Blood glucose is 380. NT-proBNP is 1800 (elevated) remainder of the labs are WNL. next orders?
Orders: admit to ward telemetry ambulate at will low satl, low cholesterol, diabetic diet fluid restriction input/output moniotor daily weights continue all home medications except glyburide KLC oral, ontinous (as long as lasix is given) start regular insulin sliding scle, ACHS Accu check ACHS Give 10 units regular insulin now Lovenox, SQ dialy for DVT prophylaxis BMP, next day (t to check renal function and electrolytes due to furosemid) HbA1c, routine lipid profie, routine Echocardiogram, routine (to asscess Left ventricular function)