Uterine corpus cancer

Question 1

Which hereditary condition is implicated in 5% of all endometrial cancers?

Answer 1

• Lynch syndrome (hereditary nonpolyposis colon cancer)

Question 2

What is type I endometrial cancer related to?

Answer 2

• Unopposed estrogen exposure

- Has good prognosis

Question 3

What is type II endometrial cancer related to?

Answer 3

• Non-estrogen related
• Chromosomal abnormality
• Poor prognosis

Question 4

How can TV ultrasound be used to investigate endometrial cancer? WHat will it show?

Answer 4

• thickened endometrium (5mm or more)

Question 5

What is the most common presenting symptom in a patient with endometrial cancer?

Answer 5

Postmenopausal bleeding (90%)

Question 6

How do you work up a patient with suspected endometrial cancer?

Answer 6

1) TV ultrasound (endometrium thickened >5mm)
* If over 4mm requires endometrial biopsy to investigate
2) Endometrial biopsy (for malignant cells)
- If positive: treatment
- If negative: hysteroscopy with fractional dilation and curettage