Uses Of IR spectroscopy Flashcards
USES of IR spec?
ID of drugs by matching specs
Functional group analysis
Detect polymorphs of drugs
BP states some preparation and operational conditions must be same for sample and reference- T/F?
TRUE
What should be used to calibrate fro similar resolution and accuracy?
Reference
Which function group usually has the sharpest/ strongest peak?
C=O
Which function group gives a broad peak?
O-H
Which function groups are present in 2500-4000nm range
O-H
C-H
N-H
Which func groups in 2000- 2500nm range?
C triple bond N
C triple bond. C
Which func groups in range 1659- 1800?
C=O
Which func groups in range 1550- 1650 ?
C=N
C=C
Which func groups in range 650- 1550?
C-O
C-N
C-C
C=O could be in the form of….?
ACID- COOH - broad as OH also present AMIDE- CONH2 if NH band also present ESTER- RCOOR- if C-O present ANHYDRIDE- RCO-O-COR- if 2 close c=o bends present ALDEHYDE- RVHO- if CH weak bands occur
If C=O absent but OH present…?
Alcohol or phenol
O-H and N-H are broad and almost in the same region- T/F?
TRUE
Primary amine (RNH2) has how many peaks?
Broad with 2 sharp spikes
Secondary amine has how many peaks?
Broad with one sharp spike
