Drug Action Flashcards
1
Q
Drug does not have to be in solution to leave GIT? T/F?
A
FALSE- must be in solution so drug needs some solubility
2
Q
What can increase dissolution of a drug in GIT?
A
- liquid dose
- salt forms
- amorphous forms
3
Q
What can slow dissolution in GIT?
A
Enteric coating
4
Q
Do drugs for inhalation need to dissolute?
A
NO- an exception
5
Q
What is the equilibrium in the GIT between?
A
Precipitation (solution—> solid) and dissolution (solid—> solution)
6
Q
Does solubility depend on pH ?
A
YES- ionisation improves solubility
7
Q
Difference between kinetic solubility and thermodynamic solubility?
A
Kinetic = influenced by formulation Thermo= innate
8
Q
Thermodynamic solubility is controlled/ determined by Gibbs free energy- T/F?
A
TRUE
