Urticaria

Question 1

Definition of urticaria?

Answer 1

vascular reaction to skin characterized by wheals with surrounding areas of erythema

cardinal symptoms = pruitis and swelling of upper dermis

Question 2

Definition of angioedema?

Answer 2

same pathogenic mechanism of urticaria, but involves deeper dermis and subcu tissue

cardinal symptom is swelling, mainly facial portion

Question 3

The major effector cell in urticaria?

Answer 3

mast cell;

immunologic urticaria is antigen binding to IgE,

non immunological can induce histamine release through arachidonic acid metabolism, physical stimuli, etc. all of which cause mast cell degranulation

Question 4

A common medication causing urticaria and angioedema is ?

Answer 4

Penicilin and related antibiotics

30% chronic urticaria is exacerbated by ASA/NSAID use

Question 5

Food allergies are more likely to cause what type of urticaria (time frame)?

Answer 5

acute