Urology/Renal Flashcards
average values of HCO3, pH, and CO2
HCO3: 24
pH: 7.40
CO2: 40
3 step acid-base approach
- normal pH range: 7.35-7.45 -> acidosis vs alkalosis
- CO2 (respiratory): normal range: 35-45
- HCO3 (metabolic): normal range: 20-26
ex.
elevated CO2, low pH: respiratory acidosis
low CO2, high pH: respiratory alkalosis
low HCO3, low pH: metabolic acidosis
elevated HCO3, elevated pH: metabolic alkalosis
6 types of urinary incontinence
urge
stress
overflow
functional
mixed
nocturnal
urinary incontinence due to detrusor overactivity
sudden urge to urinate, loss of large volumes, small post void residual
urge incontinence
tx for urge incontinence
pelvic muscle exercises
anticholinergics/TCAs
urinary incontinence due to weak pelvic floor muscles
involuntary urine loss in spurts during activities that increase abdominal pressure, small post void volume
stress incontinence
tx for stress incontinence
kevels
topical estrogens
mid-urethral sling
urinary incontinence caused by impaired detrusor contractility
inability to empty bladder -> high void post volume, nocturnal wetting
overflow incontinence
6 causes of overflow incontinence
diabetes
neuro d.o
anticholinergics/alpha agonists
BPH/prostate ca
urethral stricture
constipation/fecal impaction
tx for overflow incontinence
gs: self catheterization
cholinergics (bethanecol)
alpha blockers (tamsulosin)
urinary incontinence that involves normal voiding systems but difficulty reaching toilet 2/2 mental/physical disability
functional incontinence
tx for functional incontinence
scheduled voiding times
mixed urinary incontinence is a combo of
stess/urge
mc type of urinary incontinence
mixed
involuntary urination during sleep w.o urologic or neurologic causes after 5 yo
nocturnal enuresis
management of nocturnal enuresis (4)
UA
postvoid residual volume
urodynamic studies
US/cystoscopy
stages of acute renal failure based on GFR
stage 1 (normal): GFR > 90
stage 2 (early): GFR 60-89
stage 3 (moderate): GFR 30-59
stage 4 (severe): GFR 15-29
stage 5 (kidney failure): GFR < 15
top 2 causes of renal vascular dz
1. DM
2. HTN
other:
smoking
renal a stenosis
glomerular dz
renal cysts
genetics
_ is caused by a rise in BUN concentration
azotemia
AKI is marked by elevated serum _ and decreased _
Cr
GFR
3 types of AKI
prerenal
intrinsic
postrenal
AKI caused by decrease bloodflow to the kidneys
nephrons intact
prerenal
AKI in the kidneys
intrinsic
AKI downstream of the kidneys
postrenal
3 causes of prerenal AKI
hypovolemia - mc
NSAIDs, IV contrast, ACE/ARB
renal artery stenosis
tx for prerenal AKI
IVF
underlying cause
causes of intrinsic AKI
direct damage to the kidneys:
nephrotoxic drugs: ex aminoglycosides
cyclosporines
tumor lysis syndrome
vasculitis (SLE/Sjorgens)
gout
rhabdo
hallmark finding of intrinsic AKI
RBC casts
tx for intracellular AKI
IVF
Lasix
causes of postrenal AKI
obstruction:
nephrolithiasis
BPH/tumors
congenital/structural abnl’s
retention of nitrogenous waste
azotemia
symptomatic azotemia w. n/v/lethargy
uremia
oliguria is defined as
urine output < 400 ml/day
causes of prerenal failure
-volume loss
-HF
-loss of peripheral vascular resistance (sepsis/anesthesia)
sx of prerenal AKI (5)
weak
dizzy/orthostatic
decreased urine
sunkey eyes
tachy
labs findings of prerenal AKI
FENa nl
SpGr >1.030
Bun/Cr > 20
urine osm > 500
tx for prerenal AKI
fluids
cardiac support
treat shock
3 types of intarenal AKI
glomerular
tubular
intersitial
RBC casts
glomerulonephritis
WBC casts
pyelonephritis
muddy casts
ATN
hyaline casts
normal
waxy casts
CKD
lab findings of intrarenal AKI
SpGr < 1.010
Bun/Cr < 10
urine osm < 300
post renal failure is mc due to
prostate pathology
mc cause of post renal failure
low/no urine output
management of post renal AKI
catheter
US - find blockage/hydronephrosis
muddy, pigmented/brown granular casts
ATN
2 causes of ATN
renal ischemia (dehydration/shock/sepsis)
toxins
mc cause of ATN
prerenal failure
5 drugs associated w. ATN
amp B
cisplatin
aminoglycosides
NSAIDs
ACE
lab finding of ATN
FENa > 2%
urine osm: high
immune mediated AKI
interstitial nephritis
4 drugs assocaited w. interstitial nephritis
PCN
sulfa
NSAIDs
phenytoin
3 UA findings of interstitial nephritis
WBC casts
eosinophilia
hematuria
dx for interstitial nephritis
renal bx
management of interstitial nephritis (4)
identify offending drugs
steroids
self limiting
+/- dialysis
IgA nephropathy, postinfectious, membranoproliferative
glomerulonephritis
UA findings of glomerulonephritis
oliguria
hematuria
RBC casts
4 common causes of glomerulonephritis
GAB hemolytic strep
IgA
anti-GBM
ANCA
mc cause of acute glomerulonephritis
post streptococcal:
skin (impetigo) vs pharyngitis
triad for glomerulonephritis
hematuria
HTN
periorbital edema
dx for glomerulonephritis
UA: RBC, proteinuria
4 types of kidney stone mc -> least
- calcium oxalate
- uric acid
- struvite
- cystine
colicky, unilateral back/flank pain radiating to the groin, CVA tenderness, n/v
nephrolithiasis
labs will prob be normal for nephrolithiasis, but what abnl might you see
leukocytosis
gs dx for nephrolithiasis
CT w.o contrast (spiral CT)
CT can detect stones as small as
1 mm
tx for nephrolithiasis based on size
< 5 mm: likely to pass on their own, supportive
5-10: not likely to pass spontaneously, supportive, lithotripsy/uteroscopy w. extraction
> 10 mm: high likelihood of complication, inpt, stent/nephrostomy, opioids, lithotripsy
gs tx for kidney stones > 10 mm
ureteral stent/percutaneous nephrostomy
bacteria mc associated w. cystitis
e.coli
2 urine dipstick findings of cystitis
nitrite
leukocyte esterase
UA findings of cystitis
pyuria
bacteruria
+/- hematuria
tx for uncomplicated UTI
bactrim
nitro
x 3-5 days
tx for post coital UTIs
single dose bactrim OR cephalexin may reduce frequency
tx for UTI in pregnant pt
nitro
OR
cephalexin
31 yo M w. unilateral scrotal swelling/pain radiating to ipsilateral groin - PE shows tender, swollen testicle, scrotal edema, erythema w. shiny overlying skin
orchitis
common cause of orchitis in postpubertal males
mumps
orchitis is rarely seen w.o
epididymitis
what do you think when you see orchitis w.o epididymitis
mumps
UA findings of bacterial orchitis
pyuria
baceriuria
tx for orchitis
< 35 yo OR sexually active (over for GC/CT): ceftriaxone PLUS doxy
> 35 yo (STI not suspected): levofloxacin
5 causes of dysuria
cystitis
pyelonephritis
urethritis
epididymitis
prostatitis
gs dx for cystitis
urine cx
tx for pyelonephritis
fluroquinolones
definition for recurrent UTIs
2 uncomplicated x 6 mo
3+ complicated x 1 year
definition for UTI relapse
UTI w.in 2 weeks of tx
mc cause and dx for urethritis
mc: GC/CT
dx: NAAT
dysuria, unilateral scrotal pain
epididymitis
what sign is associated w. epididymitis
prehn’s: relief w. testicle elevation
pathogens associated w. epididymitis:
treatment for epididymitis:
< 35 yo: GC/CT
> 35 yo: e.coli
tx: fluoroquinolone OR doxy
PLUS
ceftriaxone
sudden onset f/c, lbp, increased frequency/urgency/dysuria
prostatitis
mc cause of prostatitis
< 35 yo: GC/CT
> 35 yo: e.coli
never _ a pt. w. prostatitis
prostate massage
all pt’s w. prostatitis present w. (2)
irritative bladder sx
obstruction
dx for prostatitis
-UA: pyuria and hematuria
-prostatic fluid: leukocytosis, culture
pathogens associated w. acute vs chronic prostatitis
acute: GC/CT vs. e.coli vs pseudo
chronic: enterococcus
tx for acute prostatitis
< 35 yo: ceftriaxone PLUS doxy
> 35 yo: fluoroquinolones vs bactrim x 4-6 weeks
+/- inpatient
tx for chronic prostatitis
fluoroquinolones
OR
bactrim
x6-12 weeks
when should sexual partners of epididymitis pt be treated
if contact w.in 60 days of sx onset
tx for epididymitis in pt’s wh practice insertive anal sex
ceftriaxone
PLUS
fluoroquinolone
organism mc associated w. pyelonephritis
e.coli
lab findings of pyelonephritis
leukocytosis w. left shift
US findings suggestive of complicated pyelonephritis
hydronephrosis 2/2 obstruction
tx for pyelo
outpt: cipro vs levo vs bactrim x 1-2 weeks
inpt: IV fluoroquinolones/cephalosporins/gentamycin
2 mc cause of hyperphosphatemia
1. renal failure
2. hypoparathyroidism
other:
DKA
crush injuries
rhabdo
infxn
tumor lysis
metabolic vs respiratory alkalosis
sx of severe hyperphosphatemia
diplopia
low CO
dysphagia
respiratory dpn
AMS
coma
tx for hyperphophatemia
IVF
acetazolamide
phosphate binders
lab to order if suspicious of phos or ca imbalance
PTH
causes of hypophosphatemia
hyperparathyroidism
etoh
burns
starvation
CKD
diuretics
sx of hypophosphatemia
anorexia
muscle weaknes
sz/coma
osteomalacia
causes of hypocalcemia
1. hypoparathyroidism
other: thyroid surgery, renal dz
2 PE findings of hypocalcemia
trousseau’s sign
chvostek’s sign
EKG finding of hypocalcemia
prolonged QT
what is this showing
trosseau’s sign -> hypocalcemia
what is this showing
chvostek sign -> hypocalcemia
tx for hypocalcemia
IV calcium gluconate
what is more indicative of serious electrolyte imbalance over serum levels
EKG findings
causes of hypercalcemia
1. hyperparathyroidism
other:
sarcoidosis
TB
paget dz
metastases to bone
MM
sx of hypercalcemia
stones
bones
groans
psychiatric moans
ekg finding of hypercalcemia
shortened QT
sx of hypercalcemia
polyuria
constipation
anorexia
nephrolithiasis
muscle weakness
confusion
tx for hypercalcemia
IVF
furosemide
hypercalcemia in elderly is _ until proven otherwise
in young adults, think _
elderliy: cancer
young: hyperparathyroidism
2 pt pops at high risk for hyponatremia
etoh
malnourished
3 sx of severe hyponatremia
coma
brainstem herniation
sz
t/f: chronic hyponatremia is not as emergent as acute
t!
sx of chronic hyponatremia
problems w. motor/gait -> falls
correcting chronic hyponatremia too rapidly can lead to
osmotic demyelination syndrome
tx for acute vs chronic hyponatremia
acute: 50 mL bolus of 3% saline
chronic: IV NS
hypernatremia is mc caused by
dehydration (limited access to water)
impaired thirst mechanism
other: diabetes insipidus
sx of severe hypernatremia
confusion
neuromuscular excitability
hyperreflexia
sz/coma
tx for hypernatremia
IV D5W
vs
D5W 1/2 NS
rapid correction of chronic hypernatremia can cause
cerebral edema
pontine herniation
4 causes of hyperkalemia
late CKD
spironolactone
ACEI
AKI
EKG finding of hyperkalemia
peaked T waves
tx for hyperkalemia (5)
IV insulin
glucose
albuterol
Ca gluconate
lasix
indication for imergent tx w. hyperkalemia
EKG changes
EKG progression for hyperkalemia
peaked T waves
sine waves
wide QRS: v tach/vfib
2 mc causes of hypokalemia
diuretics
cushing’s
ekg finding of hypokalemia
u waves
sx of hypokalemia (3)
muscle cramps
constipation
prolonged QT
tx for hypokalemia
IV potassium PLUS oral potassium
replace Mg
what type of fluid is most similar to the body’s plasma/serum concentration
LR
when would you use NS 0.9% (3)
hydration due to vomiting/diarrhea
hemorrhage
shock
when would you use LR
burn victims
hypovolemia due to fluid shifts
D5W is _ tonic
hypotonic
indication for D5W
DM
NPO prior to surgery
3 contraindications for D5W
renal failure
cardiac compromise
increased intracranial pressure
1/2 NS (aka 45% NS) is _ tonic
hypo
indications for 1/2 NS
cellular dehydration:
hypernatremia
DKA
avoid 1/2 NS in what pt pops
burns
trauma
depleted intravascular fluid levels
5 causes of severe diarrhea
cholera
rotavirus
norovirus
DKA
burns
dehydration causes metabolic _
acidosis
tx for dehydration
NS 0.9%
diabetes insipidus is caused by
decreased ADH:
head trauma
brain tumor
autoimmune
hyperparathyroidism
2 drugs associated w. diabetes insipidus
lithium
demecloclycine
dx for diabetes insipidus
fluid deprivation test
effect of diabetes insipidus on urine osmolarity
low
tx for diabetes insipidus
desmopressin (DDAVP)
D5W 1/2 NS
increased ADH from pituitary gland -> inability to dilute serum through kidney excretion -> too much water in the serum
SIADH
ectopic cause of SIADH
SCLC
lab finding of SIADH
hyponatremia
4 meds associated w. hyponatremia
carbamazepine
HCTZ
NSAIDs
TCAs
tx for SIADH
restrict fluids
vasopressin-2 receptor agonists (tolvapatan)
demeclocycline
what test is always required w. suprapubic/flank pain
UA
pregnancy test for females
suprapubic tenderness in males always points to _ pathology (3)
bladder
colon
prostate
rapid swelling of the kidney -> severe pain
hydronephrosis
renal/utereal colic
nephrolithiasis
do not miss for flank pain
aortic aneurysm
damage to glomeruli by deposition of inflammatory proteins in as a result of immunologic response
glomerulonephritis
t/f: glomerulonephritis has a good prognosis in kids and bad prognosis in adults
t!
4 causes of glomerulonephritis
henoch-schonlein purpura
postinfectious
IgA nephropathy
hereditary
5 sx of glomerulonephritis
hematuria -> cola/tea colored urine
oliguria/anuria
AM edema of face/eyes
PM edema of feet/ankles
HTN
what lab is increased in 60-80% of post streptococcal GN
antistreptolysin-O
lab value decreased with post strep GN
complement
tx for GN
steroids
immunosuppression
limit Na/fluid
dialysis if azotemia
ACEI if chronic
15 yo M, severe, sharp lower abd pain that radiates to left thigh, n/v - hx cryptochordism - normal vitals - scrotal exam shows diffusely tender testis, lifting of testicle does not relieve pain - loss of cremasteric reflex
testicular torsion
what is this showing
absent blood flow -> testicular torsion
what is this showing
bilateral nonattachment of testicles to gubernaculum to the scrotum -> bell clapper deformity -> increased risk for testicular torsion
timeline for testicular torsion detorsion
< 6 hr: > 90% salvage rate
after 24 hr: < 10% salvage rate
what is this showing
tender nodule 2-3 mm in diameter on upper pole of testicle -> blue dot deformity
hx clue for testicular torsion
cryptochordism
mc vs gs imaging for testicular torsion
mc: testicular doppler
gs: radionuclide scan
tx for testicular torsion
- emergent surgery
- elective surgery on contralateral side (increased risk for torsion)
ddx for hematuria
bladder ca
renal cell carcinoma
nephrolithiasis
acute GN
coagulation d.o
polycystic kidney dz
nephrolithiasis
UTI
pyelonephritis
mc causes of urethritis
HSV - mc
CT
GC
trichomonas
2 sx of urethritis
dysuria
urethral d.c
t/f: sexually active pt w. sx of urethritis is treated presumptively for STIs
t!
tx for urethritis
ceftriaxone 500 mg IM x 1
PLUS
doxy 100 mg po bid x 7 days (azithromycin if pregnant)
types of hernias (7)
umbilical
diaphragmatic/hiatal
incisional
cystocele
rectocele
inguinal
ventral
what type of hernia is espically associated w. obesity
incisional
ventral hernias can be either _ or _
incisional
umbilical
imaging for hernia
US
esp in male kiddo w. other scrotal masses