Urology/Renal Flashcards
average values of HCO3, pH, and CO2
HCO3: 24
pH: 7.40
CO2: 40
3 step acid-base approach
- normal pH range: 7.35-7.45 -> acidosis vs alkalosis
- CO2 (respiratory): normal range: 35-45
- HCO3 (metabolic): normal range: 20-26
ex.
elevated CO2, low pH: respiratory acidosis
low CO2, high pH: respiratory alkalosis
low HCO3, low pH: metabolic acidosis
elevated HCO3, elevated pH: metabolic alkalosis
6 types of urinary incontinence
urge
stress
overflow
functional
mixed
nocturnal
urinary incontinence due to detrusor overactivity
sudden urge to urinate, loss of large volumes, small post void residual
urge incontinence
tx for urge incontinence
pelvic muscle exercises
anticholinergics/TCAs
urinary incontinence due to weak pelvic floor muscles
involuntary urine loss in spurts during activities that increase abdominal pressure, small post void volume
stress incontinence
tx for stress incontinence
kevels
topical estrogens
mid-urethral sling
urinary incontinence caused by impaired detrusor contractility
inability to empty bladder -> high void post volume, nocturnal wetting
overflow incontinence
6 causes of overflow incontinence
diabetes
neuro d.o
anticholinergics/alpha agonists
BPH/prostate ca
urethral stricture
constipation/fecal impaction
tx for overflow incontinence
gs: self catheterization
cholinergics (bethanecol)
alpha blockers (tamsulosin)
urinary incontinence that involves normal voiding systems but difficulty reaching toilet 2/2 mental/physical disability
functional incontinence
tx for functional incontinence
scheduled voiding times
mixed urinary incontinence is a combo of
stess/urge
mc type of urinary incontinence
mixed
involuntary urination during sleep w.o urologic or neurologic causes after 5 yo
nocturnal enuresis
management of nocturnal enuresis (4)
UA
postvoid residual volume
urodynamic studies
US/cystoscopy
stages of acute renal failure based on GFR
stage 1 (normal): GFR > 90
stage 2 (early): GFR 60-89
stage 3 (moderate): GFR 30-59
stage 4 (severe): GFR 15-29
stage 5 (kidney failure): GFR < 15
top 2 causes of renal vascular dz
1. DM
2. HTN
other:
smoking
renal a stenosis
glomerular dz
renal cysts
genetics
_ is caused by a rise in BUN concentration
azotemia
AKI is marked by elevated serum _ and decreased _
Cr
GFR
3 types of AKI
prerenal
intrinsic
postrenal
AKI caused by decrease bloodflow to the kidneys
nephrons intact
prerenal
AKI in the kidneys
intrinsic
AKI downstream of the kidneys
postrenal
3 causes of prerenal AKI
hypovolemia - mc
NSAIDs, IV contrast, ACE/ARB
renal artery stenosis
tx for prerenal AKI
IVF
underlying cause
causes of intrinsic AKI
direct damage to the kidneys:
nephrotoxic drugs: ex aminoglycosides
cyclosporines
tumor lysis syndrome
vasculitis (SLE/Sjorgens)
gout
rhabdo
hallmark finding of intrinsic AKI
RBC casts
tx for intracellular AKI
IVF
Lasix
causes of postrenal AKI
obstruction:
nephrolithiasis
BPH/tumors
congenital/structural abnl’s
retention of nitrogenous waste
azotemia
symptomatic azotemia w. n/v/lethargy
uremia
oliguria is defined as
urine output < 400 ml/day
causes of prerenal failure
-volume loss
-HF
-loss of peripheral vascular resistance (sepsis/anesthesia)
sx of prerenal AKI (5)
weak
dizzy/orthostatic
decreased urine
sunkey eyes
tachy
labs findings of prerenal AKI
FENa nl
SpGr >1.030
Bun/Cr > 20
urine osm > 500
tx for prerenal AKI
fluids
cardiac support
treat shock
3 types of intarenal AKI
glomerular
tubular
intersitial
RBC casts
glomerulonephritis
WBC casts
pyelonephritis
muddy casts
ATN
hyaline casts
normal
waxy casts
CKD
lab findings of intrarenal AKI
SpGr < 1.010
Bun/Cr < 10
urine osm < 300
post renal failure is mc due to
prostate pathology
mc cause of post renal failure
low/no urine output
management of post renal AKI
catheter
US - find blockage/hydronephrosis
muddy, pigmented/brown granular casts
ATN
2 causes of ATN
renal ischemia (dehydration/shock/sepsis)
toxins
mc cause of ATN
prerenal failure
5 drugs associated w. ATN
amp B
cisplatin
aminoglycosides
NSAIDs
ACE
lab finding of ATN
FENa > 2%
urine osm: high
immune mediated AKI
interstitial nephritis
4 drugs assocaited w. interstitial nephritis
PCN
sulfa
NSAIDs
phenytoin
3 UA findings of interstitial nephritis
WBC casts
eosinophilia
hematuria
dx for interstitial nephritis
renal bx
management of interstitial nephritis (4)
identify offending drugs
steroids
self limiting
+/- dialysis
IgA nephropathy, postinfectious, membranoproliferative
glomerulonephritis
UA findings of glomerulonephritis
oliguria
hematuria
RBC casts
4 common causes of glomerulonephritis
GAB hemolytic strep
IgA
anti-GBM
ANCA
mc cause of acute glomerulonephritis
post streptococcal:
skin (impetigo) vs pharyngitis
triad for glomerulonephritis
hematuria
HTN
periorbital edema
dx for glomerulonephritis
UA: RBC, proteinuria
4 types of kidney stone mc -> least
- calcium oxalate
- uric acid
- struvite
- cystine
colicky, unilateral back/flank pain radiating to the groin, CVA tenderness, n/v
nephrolithiasis
labs will prob be normal for nephrolithiasis, but what abnl might you see
leukocytosis
gs dx for nephrolithiasis
CT w.o contrast (spiral CT)
CT can detect stones as small as
1 mm
tx for nephrolithiasis based on size
< 5 mm: likely to pass on their own, supportive
5-10: not likely to pass spontaneously, supportive, lithotripsy/uteroscopy w. extraction
> 10 mm: high likelihood of complication, inpt, stent/nephrostomy, opioids, lithotripsy
gs tx for kidney stones > 10 mm
ureteral stent/percutaneous nephrostomy
bacteria mc associated w. cystitis
e.coli
2 urine dipstick findings of cystitis
nitrite
leukocyte esterase
UA findings of cystitis
pyuria
bacteruria
+/- hematuria
tx for uncomplicated UTI
bactrim
nitro
x 3-5 days
tx for post coital UTIs
single dose bactrim OR cephalexin may reduce frequency
tx for UTI in pregnant pt
nitro
OR
cephalexin
31 yo M w. unilateral scrotal swelling/pain radiating to ipsilateral groin - PE shows tender, swollen testicle, scrotal edema, erythema w. shiny overlying skin
orchitis