Pulmonology Flashcards
pulmonary emergencies to know
(just to help my brain organize)
acute bronchiolitis
acute bronchitis
acute epiglottitis
acute respiratory distress syndrome (ARDS)
asthma
croup
foreign body aspiration
hemoptysis
influenza
lung ca
pertussis
pleural effusion
pleuritic chest pain
PNA
PTX
PE
RSV
TB
wheezing
mc cause of acute bronchiolitis
RSV
tachypnea, respiratory distress, wheezing in infants/young children
RSV/acute bronchiolitis
dx for acute bronchiolitis
nasal washing (RSV)
culture/antigen assay
CXR
CXR findings of acute bronchiolitis
normal
only tx that improves acute bronchiolitis
O2
indication for hospitalization for acute bronchiolitis (6)
O2 sat < 95-96%
< 3 months
RR < 70
nasal flaring
retractions
atelectasis on CXR
tx for bronchiolitis
+/- bronchodilators for sx relief
severe/immunocompromised: ribavarin, monoclonal abs (palivizumab)
what tx is not recommended for acute bronchiolitis for previously well infants
systemic steroids
definition of acute bronchitis
cough > 5 days
pathogens associated w. acute bronchitis
mc: viral
m. cat
h.flu
s.pneumo
mc bacterial cause of acute bronchitis
m.cat
t/f: fever is uncommon w. acute bronchitis
t!
2 lung sounds NOT associated w. acute bronchitis
rales
egophany
tx for acute bronchitis is mostly symptomatic, when should steroids/ribavirin/abx be used
-steroids: hx underlying RAD
-ribavirin: severe lung/heart dz, immunocompromised
-abx: elderly, underlying cardiopulm dz, cough 7-10 days, immunocompromised
indication for hospitalization for acute bronchitis
O2 < 96%
pathogen associated w. acute epiglottitis
h.flu type b (Hib)
acute epiglottitis mc affects what pt pop
unvaccinated kids
:(
Hib vaccination schedule
2, 4, 6, 12-15 months
3 d’s of epiglottitis
dysphagia
drooling
distress (respiratory)
imaging and classic finding for acute epiglottitis
lateral neck XR
thumbprint sign
what is this showing
thumbprint sign -> acute epiglottitis
management of acute epiglottitis
secure airway
culture
ceftriaxone
supportive
fluid collects in lungs -> respiratory failure -> organs deprived of O2
ARDS
hallmark of ARDS
non cardiogenic pulmonary edema
mc cause of ARDS
sepsis
also:
trauma
aspiration
near-drowning
rapid onset of dyspnea 12-24 hr after precipitating event
ARDS
3 PE findings of ARDS
tachypnea
pink, frothy sputum
crackles
CXR findings of ARDS
air bronchograms
bilaterally fluffy infiltrate
what is this showing
air bronchogram
intubation goals for ARDS
lowest level PEEP to maintain PaO2 > 60 mmHg OR SaO2 > 90
chronic, irreversible inflammatory airway dz w. recurrent attacks of breathlessness and wheezing
asthma
dx and monitoring of asthma
spirometry w. pre/post albuterol readings
spirometry findings of asthma
decreased FEV1/FVC < 80%
> 10% increase of FEV1 w. bronchodilator
what is FEV1
forced expiratory volume in the first second (should be greatest amt of air exhaled)
asthma classifications
-mild intermittent: < 2x/week OR < 2/mo night sx
-mild persistent: > 2x/week OR 3-4/mo nightly sx
-moderate persistent: daily sx OR > 1 night/week nightly sx
-severe persistent: sx severeal times/day + nightly sx
asthma tx based on classification
-mild intermittent: SABA PRN
-mild persistent: daily low dose ICS, SABA PRN
-moderate persistent: daily low dose ICS + LABA, SABA PRN
-severe persistent: daily high dose ICS + LABA, SABA PRN, +/- oral steroids
tx for acute asthma attack
O2
nebulized SABA, ipratropium bromide
oral steroids
infxn of upper airway that obstructs breathing and causes characteristic barking cough
croup
what pathogen is associated w. croup
parainfluenza
croup is mc in what pt pop
3-6 mo
2 hallmark PE findings of croup
barking cough
stridor
what is this showing
steeple sign -> croup
narrowing of trachea in subglottic region
tx for croup: nonsevere vs severe
nonsevere: supportive -> humidifier, antipyretics
severe: IVF, nebulized racemic epi, steroids
foreign body aspiration mc occurs due to
food
mc location for foreign body aspiration
mainstem or lobar bronchus
r > l
5 rf for foreign body aspiration
institutionalization
advaned age
poor dentition
etoh
sedatives
lung sound clues based on location of aspiration
inspiratory stridor: high in airway
wheezing/decreased breath sounds: low in airway
imaging for foreign body aspiration plus hallmark finding
expirational CXR -> hyperinflation of affected side
labs for foreign body aspiration
ABG
tx for foreign body aspiration kids vs adults
kids: rigid bronchoscopy
adults: flexible bronchoscopy
3 complications of foreign body aspiration
PNA
ARDS
asphyxia
3 mc causes of hemoptysis
- bronchitis
- tumor
- TB
also bronchiectasis, smoking, pulmonary htn, pulmonary catheter, pulmonary hemorrhage
what does pulmonary vascular engorgement make you think of (2)
pulmonary htn
masses
hemoptysis, dry cough vs phlegm cough
bronchitis
hemoptysis, chest pain, rib pain, tobacco, wt loss, clubbing
tumor
hemoptysis, chest pain, night sweats
TB
work up for hemoptysis
culture
cytology
fiberoptic bronchoscopy
rigid bronchoscopy
CT
preferred work up for hemoptysis w. suspected ca
high res CT
cytology
fiberoptic bronchoscopy
preferred work up for hemoptysis w. massive bleeding
rigid bronchoscopy
greater suctioning/airway maintenance
primary cause of death w. hemoptysis
asphyxiation
not exsanguination
emergent tx for hemoptysis
ABCs
mc presentation of aute or mild hemoptysis
bronchitis
older smokers w. hemoptysis must get
high res CT
t/f: negative CXR rules out lung ca
f!
duh
influenza is caused by the _ virus
orthomyxovirus
how many strains of flu are there
a, b, c
what age should people start getting the flu shot
> 6 months
contraindications for the flu shot (4)
severe egg allergy
previous rxn
guillain-barre w.in 6 weeks of prev. vaccination
< 6 months old
contraindication for flumist vaccination
asthma
CXR findings of influenza PNA
bilateral diffuse infiltrates
when should antivirals be given for flu
< 48 hr after symptom onset
what are the influenza antivirals
oseltaivir
relenza - inhaled
rapivab - IV
baloxavir
which influenza antivirals treat A and B
olsetamivir
zanamivir
indications for antivirals w. influenza
hospitalized
outpt w. severe/progessive illness
outpt at high risk for complications
who is at high risk for complications w. influenza
immunocompromised
chronic conditions
> 65 yo
pregnant or 2 weeks postpartum
categories of lung ca
small cell (SCLC) - poor prognosis
non small cell (NSCLC) - mc
4 types of NSCLC
adenocarcinoma
squamous cell carcinoma
large cell carcinoma
carcinoid
99% of SCLC can be attributed to
smoking
which location of SCLC is very aggressive
central
SCLC is associated w. what conditions
paraneoplastic syndromes
cushing’s
SIADH
SVC syndrome
pancoast tumor
horner’s syndrome
carcinoid syndrome
tx for SCLC
chemo
can’t do surgery
NSCLC adenocarcinoma is associated with a _ mass
peripheral
causes of NSCLC adenocarcinoma
smoking
asbestos
thrombophlebitis
squamous cell NSCLC presents with _
and is _ located
-hemoptysis, hypercalcemia, elevated PTHrP
-centrally
large cell NSCLC presents with _
and is _ located
gynecomastia
peripherally
NSCLC carcinoid tumors should make you think of
GI tract tumors metastasized to the lung
mc: appendix -> liver -> lung
carcinoid NSCLC presents w.
carcinoid syndrome:
cutaneous flushing
diarrhea
wheezing
hypotn
mc type of NSCLC carcinoid tumor
adenoma
bronchoscopy findings of NSCLC carcinoid tumors
pink/purple central lesion
well vascularized
lab finding of NSCLC carcinoid tumor
elevated 5-HIAA
tx for NSCLC based on stage
1-2: surgery
3: chemo
4: palliative
differentiation btw lung nodule vs mass
nodule: < 3 cm
mass: > 3 cm
steps of pulmonary nodule management
- incidental finding on CXR
- CT
- if suspicious on CT -> bx
- if not suspicious on CT and < 1 cm -> monitor at 3 mo, 6 mo, and annually x 2 years
characteristics of a suspicious pulmonary nodule
ill defined
lobular or spiculated
characteristics of a benign pulmonary nodule
calcification
smooth/well defined edges
highly contagious respiratory tract infxn marked by a severe hacking cough followed by a high pitched intake of breath
whooping cough/pertussis
bordetella pertussis is a gram _ bacteria,
and should be suspected in what pt’s (2)
-negative
-adults with cough > 2 weeks, pt’s < 2 yo
3 stages of pertussis
catarrhal: cold like sx, poor feeding/sleeping
paroxysmal: high pitched inspiratory “whoop”
convalescent: residual cough (up to 100 days)
dx for pertussis
nasopharyngeal swab culture
tx for pertussis
macrolides
steroids
beta 2 agonists
vaccination schedule for pertussis
5 doses DTap: 2, 4, 6, 15-18 mo, 4-6 yr
1 dose Tdap: 11-18 yo
expecting moms: Tdap each pregnancy @ 27-36 weeks
accumulation of excess fluid btw the layers of the leura outside the lungs
pleural effusion
describe pain w. pleural effusion
vague discomfort/sharp pain that worsens during inspiration
work up for pleural effusion includes pleurocentesis so that you can differentiate btw (2)
exudate
transudate
what criteria is used for exudative pleural fluid
light’s criteria:
-pleural fluid protein/serum protein > 0.5
-pleural fluid LDH/serum LDH > 0.6
-pleural fluid LDH > 2/3
causes of transudate pleural fluid (6)
transient:
-changes in hydrostatic pressure
-cirrhosis
-CHF
-nephrotic syndrome
-ascites
-hypoalbuminemia
causes of exudative pleural fluid (6)
PNA - mc
infxn
malignancy
cancer
PE
TB
what view is this, what is it showing
lateral decubitus
pleural effusion
gs dx for pleural effusion
thoracentesis
2 PE findings of pleural effusion
decreased tactile fremitus
dullness to percussion
isolated left sided pleural effusion is likely
exudative
right sided pleural effusion is likely
transudative
tx for pleural effusion
thoracentesis
tx for recurrent/chronic pleural effusions (2)
-pleurodesis
-indwelling catheter
mc causes of pleuritic CP (4)
**inflammation of tissues lining pleura **:
-PNA
-pericarditis
-pericardial effusion
-pancreatitis
describe pleuritic CP
intensely sharp/stabbing
burning
pain w. inhaling and exhaling
pleuritic CP is exacerbated by (2)
deep breathing
coughing/sneezing/laughing
4 types of PNA
bacterial
viral
fungal
HIV
mc cause of PNA in adults vs kids
adults: flu
kids: RSV
dx of viral PNA (3)
CXR
rapid flu/RSV
cold agglutinin titer negative
CXR findings of viral PNA
bilateral interstitial infiltrates
tx for viral PNA
tamiflu
beta 2 agonists
fluids
sx of bacterial PNA
fever
dyspnea
tachycardia/tachypnea
cough
+/- sputum
CXR findings of bacterial PNA
patchy, segmental lobar/multilobar consolidation
dx for bacterial PNA
CXR
blood cultures x 2
sputum gram stain
tx for bacterial PNA, inpt vs outpt
outpt: doxy, macrolides (based on local resistance)
inpt: ceftriaxone + azithromycin/respiratory FQ’s
what are the respiratory FQs
moxifloxacin
gemifloxacin
levofloxacin
fungal PNA is mc in what pt pops
immunocompromised:
HIV
steroids
organ transplant
5 types of fungal PNA
coccidioides (valley fever)
aspergillosis
cryptococcus
histoplasma capsulatum
pneumocystis jiroveci
which 2 fungal PNA’s are treated with fluconazole/itraconazole
coccidioides
aspergillosis
which 2 fungal PNAs are treated w. amphotericin B
cryptococcus
histoplasma capsulatum
tx for PJP
bactrim
sulfa allergy: ptenamidine
steroids
which fungal PNA is mc in western states
coccidoides (valley fever)
which fungal PNA affects pt’s w. healthy immune systems
aspergillosis
which fungal PNA is found in soil and can be complicated by meningitis
cryptococcus
which fungal PNA is characterized by apical pulmonary lesions that resemble TB
histoplasma capsulatum
where is histoplasma capsulatum typically found
misssissippi ohio river valley
zoos: bird/cat droppings
CXR findings of histoplasma capsulatum
apical lesions
mediastinal/hilar LAD
PJP is common in HIV pt’s w. CD4 count <
200
CXR findings of PJP
diffuse interstitial or bilateral perihilar infiltrates
dx for PJP
bronchoalveolar lavage PCR
HIV test
hallmark PE finding of PJP
low O2 despite supplemental O2
pharm/indication for prophylaxis for PJP
daily bactrim if CD4 < 200
what tool is used to estimate mortality of CAP to help determine inpt vs outpt tx
CURB 65:
confusion
urea >7
RR > 30
BP: SBP </= 90, DBP </= 60
>65 yo
0-1 = low risk -> outpt
2 = mod risk -> probs admit, maybe outpt
3-5 = severe risk -> admit
collapsed lung caused by accumulation of air in pleural space
PTX
PE findings of PTX (5)
acute onset ipsilateral CP
dyspnea
decreased tactile fremitus
hyperresonance
diminished breath sounds
2 types of PTX
spontaneous
traumatic
spontaneous PTX makes you think of what pt pop
tall, thin males age 10-30
4 common causes of secondary PTX
COPD
asthma
cystic fibrosis
ILD
air in pleural space from PTX increases and is unable to escape
tension PTX
what is this showing
mediastinal shift to the contralateral side, pleural air
-> tension PTX
tx for PTX based on size
< 15% diameter = small -> supportive
> 15% diameter or symptomatic = large -> CT placement
tension: large bore needles, CT placement
for all: serial CXR q 24 hr
blockage of one of the pulmonary arteries in the lungs
PE
90% of PE’s originate from cots in
deep veins of the LE
mc sx of PE
- dyspnea
- pleuritic CP
what is virchow’s triad
hypercoagulable state
trauma
venostasis
5 hypercoagulable states
surgery
cancer
OCP
pregnancy
smoking
what is homan’s sign
dorsiflexion of the foot causes pain in the calf -> DVT
ekg findings of PE
tachycardia - mc
S1Q3T3
non specific ST changes
what tool is used to assess probability of PE
wells score
initial and gs dx for PE
initial: spiral CT
gs: CTA
CXR findings of PE
westermark sign
hamptom hump
what is this showing
triangular pleural infiltrate adjacent to hilum -> hampton’s hump
what is this showing
focal oligemia (decreased vascularization)
-> westermark sign ->PE
ABG suggestive of PE
respiratory alkalosis 2/2 to hyperventilation
anticoagulation recs for PE
acute: heparin
maintenance: Xa inhibitors and DOACs
severe renal insufficiency: Warfarin
minimum duration of anticoagulation post PE
provoked: 3 months
unprovoked: 6 months
2 unprovoked: long term
leading cause of PNA and bronchiolitis in kiddos
RSV
PE findings of RSV
wheezing/coughing x months
low grade fever
nasal flaring/retractions
nail bed cyanosis
indications for RSV vaccination/prophylaxis
what is used for RSV prophylaxis
-kids w. lung issues
-kids born premature/immunocompromised
prophylaxis: synagis (palivizumab) once monthly x 4-5 months beginning in Nov
parameters for SOB
RR > 25 OR < 10
SpO2 < 92 on RA
SpO2 < 95% on high flow O2
3 mc causes of SOB
asthma
COPD
CHF
non respiratory causes of SOB
pegnancy
ASA poisoning
renal failure
anemia
pericarditis
epiglottitis
GAD
myasthenia gravis
rib fx
ABG finding of SOB
elevated CO2
tx for SOB
O2 duh (high flow vs rebreathing)
BiPAP
intubation
asthma/COPD: albuterol
CHF: lasix
all pt’s w. SOB should get what work up
CXR
CBC
CMP
BNP
troponin
EKG
what does acid fast bacilli make you think of
myobacterium tuberculosis
sx of TB
fatigue
productive cough
night sweats
wt loss
post tussive rales
rf for TB
endemic area/recent immigration
immunocompromised
prisoners
healthcare workers
how is TB transmitted
aerosolized droplets
2 types of TB screening
TST
interferon-gamma release assays (IGRAs)
mantoux test rules for TST
>5 mm = positive: HIV (+), recent contact w. (+) TB, CXR findings, organ transplant
>10 mm = positive: recent antivirals, IVDU, healthcare setting/employee, myobacteriology lab personell, comorbidities, <4 yo, kids exposed to high risk categories
>15 mm: no known rf for TB
dx for TB
guidelines for negative
-sputum for AFB and myobacterium TB cultures
at least 3 consecutive negatives
-NAAT = faster/more reliable
CXR findings of TB
cavitary lesions
ghon complexes in apex
infiltrates
CXR findings of TB
cavitary lesions
ghon complexes in apex
infiltrates
what is this showing
ghon complexes in apex -> TB
bx findings of TB
caseating granulomas
what is miliary TB
TB spread outside the lungs
what are pott dz and scrofula
pott: TB spread to vertebral column
scrofula: TB spread to cervical lymph nodes
what is this showing
Pott Dz -> TB in vertebral column
what might this be in pt w. TB
scrofula -> TB spread to cervical lymph nodes
work up for TB if PPD/IGRA is positive
- CXR
- start empiric tx if dx is likely
- if CXR is negative -> latent TB
- if CXR is positive -> active TB
tx for latent TB
4R: rifamycin x 3-4 months -> preferred
vs
3HP rifapentine PLUS isoniazid x 3 months
vs
3HR: rifampin PLUS isoniazid x 3 months
tx for active TB
4 month: rifapentine (RPT) + moxifloxacin (MOX) + isoniazid (INH) + pyrazinamide (PZA)
6-9 month: RIPE
what TB med causes QT prolongation
moxifloxacin (MOX)
s.e of RIPE
rifampin: red/orange body fluids
isoniazid: peripheral neuropathy -> give w. B6 (pyridoxine)
pyrazinamide: hyperuricemia -> gout
ethambutol: optic neuritis/red-green blindness
which TB med needs to be given w. pyridoxine
isoniazid
all TB meds are _toxic
hepato
get baseline labs
indications for tx cessation for pt’s w. active TB
negative AFB smears/cultures x 2
prophylactic tx for household members of active TB pt
isoniazid x 1 year
lab indication that you need to stop TB tx
LFTs < 3-5 x ULN
3 considerations for pt on TB tx
monitor SCr and LFTs
take meds on empty stomach
lots of ddi - esp HIV meds