Urology drugs

Question 1

Example of alpha blocker drug?

Answer 1

Doxazosin

Question 2

How does doxazosin work?

Answer 2

Selective, competitive alpha1-adrenergic receptor antagonist, decreases peripheral vascular resistance leading to decreased blood pressure. Also selectively blocks a1 receptors in urological smooth muscle so reduces symptoms

Question 3

What class of drug is finasteride?

Answer 3

5 alpha reductase inhibitor/anti-androgen

Question 4

How does finasteride work?

Answer 4

Inhibits 5a reductase, preventing conversion of testosterone which is needed for growth of prostate tissue

Question 5

Indications for doxazosin and finasteride?

Answer 5

Benign Prostatic Hyperplasia. Doxasozin also used in HTN, finasteride also used in male pattern baldness

Question 6

Side effects of finasteride?

Answer 6

Impotence, reduced libido, ejaculation disorders, breast tenderness and enlargement - could represent breast Ca, testicular pain

Question 7

Example of xanthine oxidase inhibitor?

Answer 7

Allopurinol

Question 8

How does allopurinol work?

Answer 8

Inhibits xanthine oxidase so lowers levels of uric acid in the plasma and urine

Question 9

Indications for allopurinol?

Answer 9

Gout and renal stone prophylaxis, prophylaxis of hyperuricaemia associated with cancer chemo

Question 10

Use of allopurinol and which drugs increases the risk of rashes?

Answer 10

Ampicillin/amoxicillin

Question 11

Why does allopurinol use need to be stopped immediately if skin rashes develop?

Answer 11

Could progress to Stevens-Johnsons syndrome or Toxic Epidermal Necrosis