Respiratory drugs Flashcards
What class of drug is salbutamol?
Short acting selective B2 agonist
What can happen if atomoxetine is given with parenteral salbutamol?
Increased risk of CV side effects
What drug class is tiotropium?
Antimuscarinic bronchodilators
Why should the use of 2+ antimuscarinic drugs be cautioned?
Can increase the risk of antimuscarinic side effects such as dry mouth, urine retention and constipation
Prednisolone is an example of which type of drug?
Corticosteroids
How does prednisolone work?
Inhibits phospholipase A2 activity, reducing arachidonic acid production which therefore reduces prostaglandin and leukotriene synthesis => anti-inflammatory effect
How should prednisolone be withdrawn?
Slowly, risk of acute adrenal crisis if withdrawn abruptly
Example of mucolytic?
Carbocysteine
How does carbocysteine work?
Reduces goblet cell hyperplasia and breaks down mucous making it less thick and sticky
When should carbocysteine use be avoided?
Active peptic ulceration, can increase GI bleed risk
How does theophylline work?
Relaxes bronchial smooth muscle, also suppresses eosinophil and neutrophil function.
When should theophyline use be avoided?
Porphyria. Caution use in cardiac arrhythmia, HTN, hyperthyroidism, peptic ulcer, epilepsy, elderly, fever
