urology

Question 1

doxazocin

Answer 1

alpha blocker

Question 2

how do alpha blockers work

Answer 2

vasodilation = fall in BP and reduced resistance to bladder outflow

Question 3

indications for alpha blockers

Answer 3

first line option to improve symptoms of benign prostatic hyperplasia where lifestyle changes are insufficient

add on treatment for resistant hypertension

Question 4

contraindications of alpha blockers

Answer 4

postural hypotension

Question 5

side effects of alpha blockers

Answer 5

postural hypotension, dizziness and syncope

particularly after first dose, rather like ACEi and angiotensin receptor blockers

Question 6

interactions of alpha blockers

Answer 6

combining with antihypertensive = hypotension risk

Question 7

finasteride

Answer 7

5 alpha-reductase inhibitor

Question 8

how does finasteride/5alpha-reductase inhibitors work?

Answer 8

reduce prostatic enlargement and improves urinary flow (inhibits dihydrotestosterone), can take a while to work tho

Question 9

indications for finasteride/5alpha-reductase inhibitors?

Answer 9

BPH - second line treatment after alpha blocker

improve lower UTI symptoms

reduce need for prostate related surgery

Question 10

contraindications for finasteride/5alpha-reductase inhibitors?

Answer 10

feotus = abnormal external genitalia

so not in pregnant women or men wanting to conceive

Question 11

side effects of finasteride/5alpha-reductase inhibitors?

Answer 11

impotence
reduced libido
gynaecomastia
androgen inhibition - prevents male pattern balding

breast cancer in men