Urinary Tract Calculi Flashcards
List 4 general risk factors for stones?
- Dehydration
- High dietary oxalate
- Renal tubular acidosis
- Polycystic kidney disease
List the 2 key complications of kidney stones?
- Obstruction leading to AKI
- Infection with obstructive pyelonephritis
What is the most common type of stone?
List the 2 types?
Calcium-based stones
- Calcium oxalate (more common)
- Calcium phosphate
List 2 key risk factors for calcium stones
- Hypercalcaemia
- Low urine output
How does hypercalcemia present?
Renal stones, painful bones, abdominal groans and psychiatric moans
List 2 drugs which precipitate calcium stones
- loop diuretics
- steroids
- acetazolamide
- theophylline
List the 3 key causes of hypercalcemia
- Calcium supplementation
- Hyperparathyroidism
- Cancer (ie. myeloma, breast or lung cancer)
Which drug may prevent calcium stones?
Thiazides (increase distal tubular calcium resorption)
List 3 other types of kidney stones
- Uric acid (not visible on x-ray)
- Struvite
- Cystine
List 2 risk factors for urate stones
- gout
- ileostomy (loss of HCO3 and fluid results in acidic urine)
What are Struvite stones associated with?
Produced by bacteria, therefore, associated with infection
What are the components of a Struvite stone?
Magnesium, ammonium and phosphate
What are Cystine stones associated with?
Associated with cystinuria, an autosomal recessive disease
What is a Staghorn Calculus?
Stone forms in the shape of the renal pelvis and extends into at least 2 calyces
(resemble antlers of a deer)
Staghorn Calculus occur most commonly with what type of stone?
Why?
Struvite
In recurrent upper UTIs, bacteria hydrolyse urea in urine to ammonia, creating struvite