Urinary Sediment Flashcards
Smooth, Non-nucleated biconcave disc
Red Blood Cell
Normal Value of RBC in urine
0-2 cells/10 HPF
size of RBC
7mm
(Concentrated): Shrink → Crenated
Hypersthenuric
(Diluted): Swell and lyse → leaving cell membrane only → Ghost cell
Hyposthenuric
(cellular protrusions, fragmented): Glomerular Bleeding
Dysmorphic
Urine appears cloudy with a red to brown color
Macroscopic (Gross) hematuria
Associated with advanced glomerular damage, can also be seen with damage to the vascular integrity of the urinary tract caused by trauma, acute infection or inflammation and coagulation disorders
Macroscopic (Gross) hematuria
Presence of RBC can be seen only under the microscope, normal color
Microscopic hematuria
Can be critical to the early diagnosis of glomerular disorder and malignancy of the urinary tract and to confirm the presence of renal calculi (kidney stones)
Microscopic hematuria
Associated with damage to the glomerular membrane or vascular injury within genitourinary tract
RBC
The number of cells present is indicative of the extent of damage and injury
RBC
Increased in urinary WBC
Pyuria
Predominant, has granules and multilobed
Neutrophil
(absorbs water and swell)
Hypotonic
granules exhibit Brownian movement → sparkling appearance or appear as
“Glitter cells”
Drug-induced interstitial nephritis, small numbers can be seen in UTI and renal transplant rejection
Eosinophil
Ex. of Mononuclear cells
Lymphocytes, Monocytes, Macrophage, Histiocytes
resembles RBC because they are both small
Lymphocytes
large cells with vacuoles, may or may not contain inclusions
Monocytes, Macrophage, Histiocytes
increase in urinary WBCs which indicates the presence of an infection or inflammation in the genitourinary system
Pyuria
seen in increased number in the early stages of renal transplant rejection
Lymphocytes
(usually larger than WBCs with an eccentrically located nucleus)
renal tubular epithelia cells
Primary concern in identification of WBC in urine:
differentiation of mononuclear cells and disintegrating neutrophils from round renal tubular epithelia cells
used to enhance nuclear detail
Supravital staining / Addition of acetic acid
Normal, Sloughing off
Squamous EC
largest cells found in urine sediment, derived from the genitourinary tract
Squamous EC
They represent normal cellular sloughing and have no pathologic significance
Squamous EC
Urothelial
Transitional EC
Smaller than squamous cells and appear in several forms, including spherical, polyhedral and caudate
Transitional EC
These differences are caused by the ability of transitional epithelial cells to absorb large amounts of water
Transitional EC