URINARY PATHOLOGY POWERPOINT Flashcards
pathology of the urinary system includes (6):
- Renal cystic disease
- Hematoma
- Abscess
- Nephritis
- Necrosis
- Renal failure
how are renal masses classified w/ sonography?
cystic, solid, or complex
what are the characteristics of a simple cyst?
Smooth, thin, well-defined border
Round or oval shape
Sharp interface between the cyst and renal parenchyma
No internal echoes (anechoic)
Increased posterior acoustic enhancement
true or false? about 50% of pt over age 50 have a simple renal cyst.
true
what is the criteria of a simple cystic mass
simple cyst:
- Smooth, thin, well-defined border
- Round or oval shape
- Sharp interface between the cyst and renal parenchyma
- No internal echoes (anechoic)
- Increased posterior acoustic enhancement
simple cyst images
simple cyst image
what are the characteristics of a solid mass?
- Irregular borders
- Poorly defined interface between the mass and kidney
- Low-level internal echoes
- Weak posterior border (because of the increased attenuation of the mass)
- Poor through-transmission
true or false? Complex mass shows characteristics associated with both cystic and solid lesions. Areas of necrosis, hemorrhage, abscess, or calcification within the mass
true
true or false? complex cysts may contain septations, thick walls, calcifications, internal echoes, and mural nodularity
true
clinical S/S of inflammoatory or necrotic cysts?
- Flank pain
- hematuria
- proteinuria
- white blood cells in urine
Clinical S/S of renal subcapsular hematoma?
- Hematuria
- hematocrit
clinical S/S of renal inflammatory processes?
- Abscess
- acute onset of symptoms
- fever
- palpable mass
- increased white blood cell count
- pyuria
what are the clinical S/S of acute focal bacterial nephritis?
- Fever
- flank pain
- pyuria
- elevated blood urea nitrogen (BUN)
- elevated albumin
- increased total plasma proteins
clinical S/S of acute tubular necrosis?
- Moderate-to-severe intermittent flank pain
- vomiting
- hematuria
- infection
- leukocytosis with infection
clinical S/S of chronic renal failure?
- Increased concentration of urea in blood
- high urine protein excretion
- elevated creatinine
- presence of granulocytes
what are the clinical S/S of renal cell carcinoma?
- Erythrocytosis
- leukocytosis
- red blood cells in urine
- pyruia
- increased lactic acid dehydrogenase
true or false? polycystic renal disease may present in one of two forms; the infantile autosomal recesssive form and the adult autosomal dominant form.
true
what is simple renal cystic disease?
- Encompasses a wide range of disease processes
- Typical, complicated, or atypical
- May be acquired (nongenetic) or inherited (genetic)
- Can occur in the renal cortex, medulla, or renal sinus
what are simple renal cysts? incidence? appearance?
- Acquired lesions, probably from obstructed ducts or tubules
- Estimated incidence: 50% of the population older than 50 years of age
- Asymptomatic; incidental finding
- Solitary or multiple
- One or both kidney involvement
cysts may be complicated by ______, ______, or _______ and become a complex cyst.
hemmorhage, infection, or calcification
cysts in the pediatric patient: differentiate a benign cyst from a cystic form of _______. (_____ _____)
nephroblastoma (Wilm’s tumor)
characteristics of a complex cyst:
- May contain septations, thick walls, calcifications, internal echoes, and mural nodularity.
- Considered malignant until proven benign
- Internal echoes are often the result of protein content, hemorrhage, and/or infection.
- Any irregularity at the base of the cyst should be considered a malignant growth.
- If septa is thicker than 1 mm with vascularity on color or power Doppler, the lesion is presumed malignant.
The renal sinus parapelvic cysts are ____ cysts that originate from the renal ___, most likely ______ in origin
small; sinus; lymphatic
do renal sinus parapelvic cysts communicate with the collecting system?
no
true or false? renal sinus parapelvic cysts are largely asymptomatic, but may occasionally cause pain, hematuria, hypertension, or obstruction
true
a _______ ______ (renal sinus cyst) is found in the renal hilum but does not communicate with the renal collecting system.
parapelvic cyst
which renal cysts are associated with renal neoplasms?
Von Hippel-Lindau
Tuberous Sclerosis
Acquired Cystic Kidney Disease
the sonographic appearance of tuber slcerosis may be difficult to differentiate from ____ _______ _____ disease.
adult polycystic kidney
autosomal -recessive polycystic kidney disease (ARPKD) is a ___ disorder that affects ____, chromosome __
rare; infants; 6
autosomal -dominant polycystic kidney disease (ADPKD) is a ____ disorder that affects ____, and the severity varies depending upon the _____
common; adults; genotype
true or false? with ARPKD dilation of the renal collecting tubules causes renal failure, and the liver is involved in the advanced stages.
true
What are the 4 kinds of ARPKD and what does the diagnosis depend on?
4 types
- perinatal
- neonatal
- infantile
- juvenile
type diagnosed depends on patient age at the onset of clinical signs
the ______ form of ARPKD is found in utero and usually progresses to renal failure, causing pulmonary hypoplasia and intrauterine demise
perinatal
what are the signs and findings of juvenile ARPKD?
these all Cause portal hypertension and esophageal varices
- Hypertension
- Renal insufficiency
- Nephromegaly
- Hepatic cysts
- Bile duct proliferation
- Caroli disease of the liver
- Periportal fibrosis
true or false? In older children with juvenile ARPKD, kidneys are enlarged with echogenic cortex and medulla, and corticomedullary differentiation is lacking.
true
what condition may also be microscopic or small cysts (1 to 2 mm) located in the medulla; are often associated with hepatic fibrosis and splenomegaly
juvenile autosomal-recessive polycystic kidney disease
(ARPKD)
true or false? autosomal-dominant polycystic kidney disease (ADPKD) is a bilateral progressive disease where kidneys are enlarged with multiple asymmetrical cysts (size varies) and are located in the renal cortex and medulla
true
what condition doesnt usually manifest until age 40 or 50 when hypertension or hematuria develops, and by age 60, approximately 50% of the patients have end-stage renal disease
autosomal dominant polycystic kidney disease (ADPKD)-adults
polycystic kidney disease
polycystic kidney disease
the nephroblastoma or ____ ____ is the most common solid renal mass of childhood peaking at age 2 and can reoccur.
Wilms tumor
true or false?
A simple renal cyst is an acquired lesion, probably from obstructed ducts or tubules that is asymptomatic, may be solitary or multiple and involves 1 or 2 kidneys
Estimated incidence: 50% of the population older than 50 years of age
true
Images of ADPKD
autosomal dominant polycystic kidney disease
(adult)
Images of ADPKD
autosomal dominant polycystic kidney disease
(adult)
images of polycystic kidney disease
images of polycystic kidney disease
what disease is this: a diffuse foci calcium deposits are usually located in the medula; may be seen in the renal cortex
nephrocalcinosis
what is corticomedullary differentiation?
you can not really differentiate cortex from the medulla; seen w/ MSK
Renal cell carcinoma tumors less than 3 cm are usually hyperechoic and it is hard to tell the difference between them and what other pathology?
angiomyolipomas
renal lymphoma may be confused with a ____.
renal cyst
what are the clinical symptoms of ADPKD?
Pain, hypertension, palpable mass, hematuria, headache, urinary tract infection, renal insufficiency
what are the complications of autosomal dominant polycystic disease?
Infection, hemorrhage, stone formation, rupture of cyst, renal obstruction
what abnormalities are associated w/ autosomal dependant polycystic kidney disease(ADPKD)?
it will be in the organs
- Cysts in the liver, spleen, pancreas, thyroid, ovary, testes, and breast
- Cerebral berry aneurysm
- Abdominal aortic aneurysm
true or false? patients w/ autosomal dependant polycystic kidney disease on renal dialysis have increased incidence of renal cell carcinoma
true
true or false? polycystic renal disease may present in one of two forms; infantile autosomal recessive form (rare) and the adult autosomal dominant form
true
______ ______ ______ disease is a common nonhereditary renal dysplasia that usually occurs unilaterally w/ the kidney functioning poorly, if at all and is the most common form of cystic disease in neonates and is believed to be the consequence of early in utero urinary tract obstruction
multicystic dysplastic kidney (MCDK)
____ changes usually involve the entire kidney, and bilateral involvement is incompatible with life
dysplastic
complications of multicystic dysplastic kidney (MCDK) complications:
- Hypertension
- hematuria
- infection
- flank pain
- Slight increased risk of malignancy if kidney is not removed
what are the sonographic findings of multicystic dysplastic kidney in children and adults?
- Neonates and children: Kidneys are multicystic, with the absence of the renal parenchyma, renal sinus, and atretic renal artery.
- Adults: Kidneys may be small (atrophic and calcified) and echogenic.
what is nephrocalcinosis?
Renal parenchymal calcium deposits that may be seen in patients with Medullary Sponge Kidney. affects both kidneys and diffuse foci calcium deposits are usually located in the medulla; may be seen in the renal cortex.
______ _______is most commonly seen with chronic glomerulonephritis, chronic hypercalemic states, sickle cell disease, and rejected renal transplants
Cortical nephrocalcinosis
true or false? Calcification seen in nephrocalcinosis may be dystrophic from devitalized tissues, ischemia and/or necrosis, or from hypercalemic states, hyperparathyroidism, renal tubular acidosis, and renal failure.
true
____ _____ _____ is a development anomaly that occurs in the medullary pyramids and consists of cystic or fusiform dilation of the distal collecting ducts (ducts of Bellini), causing stasis of urine and stone formation.
medullary sponge kidney (MSK)
____ _____ _____ is an anatomic defect and therefore may be unilateral or segmental, and many patients are asymptomatic.
medullary sponge kidney (MSK)
Patients with hematuria, infection, and renal stones should be evaluated for ____ ____ ____.
meduallary sponge kidney (MSK)
medullary sponge kidney (MSK) images
what are the sonographic findings of meduallary sponge kidney (MSK)?
- Small echogenic kidneys
- Loss of corticomedullary differentiation (can’t tell cortex from medulla)
- Multiple medullary small cysts under 2 cm
- With MSK, hyperechoic calyces, with or without stones
when is a renal mass considered malignant?
- a solid renal mass, is considered malignant unless fat is present.
- renal mass w/ calcifications
- If a cystic renal mass is not simple