Urinary Incontinence Flashcards

1
Q

Which nerves control storage, voiding, and somatic control respectively?

A

Storage - hypogastric (Sympathetics)
Voiding - Pelvic (Parasympathetic)
Somatic control - Pudendal

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2
Q

What two things must occur for voiding to occur?

A

Urethral sphincter relaxation (NO)

Bladder contraction via the detrusor muscle contraction (pelvic nerve and ACh)

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3
Q

What are some types of incontinence and common causes?

A

Urge - UTI,
Stress - reduced sphincter function
Overflow - outflow obstruction, detrusor weakness
Continuous - fistula
Functional - impaired cognition, psychiatric

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4
Q

What is the DIAPPERS mnemonic for causes of treatable incontinence?

A
D - Delirium
I - Infection
A - Atrophy urethritis, vaginitis
P - Pharmaceuticals
P - Psychological 
E - Excessive urine output
R - Restricted mobility
S - Stool impaction
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5
Q

How do you treat incontinence due to detrusor overactivity?

A
  • Behavioural techniques - bladder training, posture
  • Pelvic floor muscle strengthening
  • Anti-cholinergics - Oxybutynin on PBS, mirobagron (alpha 3 agonist)
  • Intradetrusion botulinum toxin A
  • Surgery
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6
Q

How do you treat outflow track obstruction?

A

Treat cause

  • Prostate - alpha blockage, 5 alpha reductase inhibitors
  • TURP
  • Women - gyne repair
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7
Q

How do you treat stress incontinence?

A

Pelvic floor exercises
Electrosimulation and biofeedback
Avoid triggers
Intravaginal devices

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8
Q

What are the storage symptoms?

A

Frequency (>8 during the day), urgency, Nocturia

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9
Q

What are the voiding symptoms?

A

Hesitancy, poor stream, intermittency, straining, drilling

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10
Q

What causes stress incontinence?

A

Sphincter weakness

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11
Q

Which part of the CNS controls micturition?

A

Pons micturition centre

Sacral micturition centre

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12
Q

How does caffeine affect the bladder?

A

Causes detrusor hyperactivity

Coffee also has a diuretic effect

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13
Q

Does does diabetes affect continence?

A

Osmotic diuresis with glucose
Autonomic neuropathy
Glucosuria = increase risk of UTIs

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14
Q

How does autonomic neuropathy affect the bladder?

A

Starts out causing hyperactivity

This is followed by bladder enlargement, then underactivity and acontractility > residual volume

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15
Q

What is a normal residual volume? What about in the elderly?

A

less than 50ml

less than 100ml unless symptomatic

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16
Q

How does constipation affect continence?

A

Stool puts pressure on the bladder

Straining affects the pelvic floor

17
Q

What is constipation?

A

Infrequent passage of stool

Hardness of stools

18
Q

How do benzodiazepines affect continence?

A

They reduce arousal and cause people to wake later causing a functional incontinence

19
Q

How does peripheral oedema effect continence?

A

Nocturnal polyuria as fluid returns to the intravascular space causing polyuria

20
Q

What is the definition of nocturnal polyuria?

A

1/3 of daily urine output during the night (including first urination in the morning)

21
Q

How do calcium channel blockers relate to continence?

A

Constipation and urinary retention due to smooth muscle affect
Particularly verapamil

22
Q

What is atrophic vaginitis? Mx?

A

Age related reduction in vaginal secretions causes excoriation, rash > dysuria, nappy rash

Topical vaginal oestrogen or pessary

23
Q

When don’t you use topical oestrogen?

A

Recent hx of breast cancer because of slight systemic absorption

24
Q

How do you Mx constipation?

A
Lifestyle
- 1.5L water
- Fibre 
- Exercise
Pharmacological
- Coloxyl and senna
- Silium 
- Movicol (bulking agent)
- Fibrogel 
- Lactulose
25
How does coloxyl and senna work?
Coloxyl is a softer | Senna is a stimulant
26
How is the mx of bowels in spinal cord patients different?
Coloxyl with every meal 5 Senna at night, alternant days So a bowel day every second day
27
Which anti-cholinergics are used? What are their SE's?
Oxybutynin Solifenacin Darifenacin Anti-SLUD, confusion in the elderly
28
Which other medications have anti-cholinergic affects?
Anti-depressants | Anti-psychotics
29
What is Mirobagron? What is the advantage of its use?
B3 agonist - synergic with the sympathetic action to help storage Little SEs except increase bioavailability of metoprolol and dig Increases metoprolol and digoxin levels when used
30
What are second line therapies for detrusor overactivity?
Intradetrusor botox - paralyses bladder to reduce bladder pressures 100units to reduce urgency but maintaining voiding capacity 200unit for total acontractility therefore requiring self-catheterisation Wears off after 8-9months +/- Self-catheterisation
31
When is desmopressin used?
In nocturnal polyuria - used mainly in children
32
Which drugs can adversely affect continence?
``` Opioids - constipation Diuretics Ca2+ channel blockers - impaired external sphincter contraction, and constipation EtOH Caffeine SGLT2s BZD ```