Parkinson's Disease Flashcards
1
Q
What is the mechanism of action of Amantadine?
A
Increases dopamine release and block cholinergic receptors
Acts as an N-Methyl-D-Aspartate antagonist in the glutamatergic pathway from subthalamic nucleus to globus pallidus.
2
Q
What are the pharmacological therapies in PD?
A
Madopar (levodopa and benserazide)
3
Q
What is the mechanism of action benserazide?
A
Inhibits the peripheral decarboxylation of levodopa into dopamine to but not in the CNS as it doesn’t cross the BBB
4
Q
What is the use and mechanism of action of benztropine?
A
Used in end stage PD for medications SE’s
Centrally acting anticholinergic/antihistamine
