Fronto-temporal dementia Flashcards
1
Q
What features are characteristics of bvFTD?
A
- Impaired attention and executive dysfunction, behavioural disinhibition
- Aphasia leading to mutism
- Hyperorality
- Slow speech
- Perseveration, Mental rigidity
- Affect change - depression, anxiety, excessive sentimentality
- Heritability
- Younger age
2
Q
What are the pathological features of bvFTD?
A
Cortical atrophy
Primary tauopathy
3
Q
What physical signs are found in bvFTD?
A
Cortical release signs
- Globellar tap
- Pout
- Palmomental reflex
4
Q
How is bvFTD managed?
A
Social intervention, counselling, speech/language/cognitive therapy
Anti-depressants, cholinesterase inhibitors
5
Q
What is the pathophysiology of bvFTD?
A
Mutation in the microtubule associated protein tau (MAPT) gene causing a tauopathy and cortical atrophy
6
Q
What is found in cognitive testing for FTD?
A
MMSE can be preserved
Frontal tests such as verbal fluency, abstraction, and alternating tasks are often poor
7
Q
Where is the mutation in FTD?
A
FTD protein mutation on chromosome 17
