urinary Flashcards
Layers Surrounding the Kidney
Renal Capsule: Fibrous sac covering the kidney.
Adipose Capsule: Cushion of fat around the kidney.
Renal Fascia: Anchors the kidney to surrounding structures.
Hilus (Hilum)
Entry/exit for blood vessels, nerves, lymphatics, and ureters.
Cortex
Outer layer; contains renal corpuscles.
Medulla
Inner layer; contains renal pyramids.
Renal Pyramids
Contain collecting ducts, apex forms renal papilla.
Renal Columns
Inward extensions of cortex between pyramids.
Renal Lobes
One pyramid plus surrounding cortical tissue.
Glomerulus
Capillary tuft where filtration occurs (fenestrated capillaries).
Bowman’s Capsule
Parietal Layer: Simple squamous epithelium.
Visceral Layer: Podocytes with filtration slits.
Filtration Membrane
Fenestrated endothelium of capillaries.
Basement membrane.
Filtration slits of podocytes.
Proximal Convoluted Tubule (PCT):
Site of most reabsorption (water, ions, nutrients).
Contains microvilli for increased surface area.
Loop of Henle
Descending Limb: Reabsorbs water.
Ascending Limb: Reabsorbs ions (Na⁺, Cl⁻).
Distal Convoluted Tubule (DCT)
Reabsorption regulated by hormones (ADH, aldosterone).
Collecting Duct:
Receives filtrate from multiple nephrons.
Final site for water and ion reabsorption.
Filtration
Occurs in glomerulus.
Produces filtrate (similar to plasma but without large proteins/cells).
Reabsorption
99% of filtrate reabsorbed.
Occurs in PCT, Loop of Henle, DCT, and collecting duct.
Reabsorbed substances: Water, glucose, amino acids, ions.
Secretion
Active process of removing unwanted substances (e.g., drugs, toxins, excess ions) from blood into filtrate.
Occurs in PCT, DCT, and collecting ducts.
Juxtaglomerular Apparatus
Juxtaglomerular Cells: In afferent arteriole, secrete renin in response to low BP.
Macula Densa: Chemoreceptors in DCT that monitor solute concentration.
Renin-Angiotensin-Aldosterone System (RAAS)
Renin triggers angiotensin II production, leading to aldosterone release.
Aldosterone increases Na⁺ and water reabsorption in DCT.
ADH (Antidiuretic Hormone)
Released by posterior pituitary.
Increases water reabsorption in collecting ducts.
ANP (Atrial Natriuretic Peptide)
Reduces Na⁺ reabsorption, decreasing blood pressure.
Ureters
Transport urine from kidneys to bladder via peristalsis.
Lined with transitional epithelium.
Bladder
Stores urine (~500 ml capacity).
Detrusor Muscle: Smooth muscle for contraction during urination.
Lined with transitional epithelium for stretch.
Urethra:
Carries urine out of the body.
Males: Prostatic, membranous, and spongy urethra (also carries semen).
Females: Shorter, only for urine.
Micturition (Urination)
Reflex controlled by the pons.
Steps:
Bladder fills, stretch receptors send signal to pons.
Parasympathetic stimulation causes:
Detrusor muscle contraction.
Internal urethral sphincter relaxation.
Voluntary relaxation of external urethral sphincter (skeletal muscle).