Upper GI Bleeding, C40 P254-270 Flashcards
What is it?
P254
Bleeding into the lumen of the proximal
GI tract, proximal to the ligament of
Treitz
What are the signs/symptoms?
P254
Hematemesis, melena, syncope, shock, fatigue, coffee-ground emesis, hematochezia, epigastric discomfort, epigastric tenderness, signs of hypovolemia, guaiac-positive stools
Why is it possible to have
hematochezia?
P254
Blood is a cathartic and hematochezia
usually indicates a vigorous rate of
bleeding from the UGI source
Are stools melenic or melanotic?
P254
Melenic (melanotic is incorrect)
How much blood do you
need to have melena?
P254
>50 cc of blood
What are the risk factors?
P254
Alcohol, cigarettes, liver disease, burn/ trauma, aspirin/NSAIDs, vomiting, sepsis, steroids, previous UGI bleeding, history of peptic ulcer disease (PUD), esophageal varices, portal hypertension, splenic vein thrombosis, abdominal aortic aneurysm repair (aortoenteric fistula), burn injury, trauma
What is the most common
cause of significant UGI
bleeding?
P255
PUD—duodenal and gastric ulcers (50%)
What is the common
differential diagnosis of
UGI bleeding?
P255
- Acute gastritis
- Duodenal ulcer
- Esophageal varices
- Gastric ulcer
- Esophageal
- Mallory-Weiss tear
What is the uncommon
differential diagnosis of
UGI bleeding?
P255
Gastric cancer, hemobilia, duodenal diverticula, gastric volvulus, Boerhaave’s syndrome, aortoenteric fistula, paraesophageal hiatal hernia, epistaxis, NGT irritation, Dieulafoy’s ulcer, angiodysplasia
Which diagnostic tests are useful?
P255
History, NGT aspirate, abdominal x-ray,
endoscopy (EGD)
What is the diagnostic test of
choice with UGI bleeding?
P255
EGD ( >95% diagnosis rate)
What are the treatment
options with the endoscope
during an EGD?
P255
Coagulation, injection of epinephrine
(for vasoconstriction), injection of
sclerosing agents (varices), variceal ligation
(banding)
Which lab tests should be performed?
P255
Chem-7, bilirubin, LFTs, CBC,
type & cross, PT/PTT, amylase
Why is BUN elevated?
P255
Because of absorption of blood by the GI
tract
What is the initial treatment?
P255
1. IVFs (16 G or larger peripheral IVS x 2), Foley catheter (monitor fluid status) 2. NGT suction (determine rate and amount of blood) 3. Water lavage (use warm H(2)O—will remove clots) 4. EGD: endoscopy (determine etiology/ location of bleeding and possible treatment—coagulate bleeders)
Why irrigate in an upper GI bleed?
P256
To remove the blood clot so you can see
the mucosa
What test may help identify the site of MASSIVE UGI bleeding when EGD fails to diagnose cause and blood continues per NGT? P256
Selective mesenteric angiography
What are the indications for
surgical intervention in UGI
bleeding?
P256
Refractory or recurrent bleeding and site
known, >3 u PRBCS to stabilize or
>6 u PRBCs overall
What percentage of patients
require surgery?
P256
≈10%
What percentage of patients
spontaneously stop bleeding?
P256
≈80% to 85%
What is the mortality of acute
UGI bleeding?
P256
Overall 10%, 60–80 years of age 15%,
older than 80 years of age 25%
What are the risk factors for
death following UGI bleed?
P256
Age older than 60 years
Shock
>5 units of PRBC transfusion
Concomitant health problems
PEPTIC ULCER DISEASE (PUD)
What is it?
P256
Gastric and duodenal ulcers
PEPTIC ULCER DISEASE (PUD)
What is the incidence in the
United States?
P256
≈10% of the population will suffer from
PUD during their lifetime!
PEPTIC ULCER DISEASE (PUD)
What are the possible
consequences of PUD?
P256
Pain, hemorrhage, perforation, obstruction
PEPTIC ULCER DISEASE (PUD) What percentage of patients with PUD develops bleeding from the ulcer? P256
≈20%
PEPTIC ULCER DISEASE (PUD)
Which bacteria are associated with PUD?
P256
Helicobacter pylori
PEPTIC ULCER DISEASE (PUD)
What is the treatment?
P257
Treat H. pylori with MOC or ACO 2-week antibiotic regimens: MOC: Metronidazole, Omeprazole, Clarithromycin (Think: MOCk) or ACO: Ampicillin, Clarithromycin, Omeprazole
PEPTIC ULCER DISEASE (PUD) What is the name of the sign with RLQ pain/peritonitis as a result of succus collecting from a perforated peptic ulcer? P257
Valentino’s sign
DUODENAL ULCERS
In which age group are
these ulcers most common?
P257
40–65 years of age (younger than
patients with gastric ulcer)
DUODENAL ULCERS
What is the ratio of male to
female patients?
P257
Men > women (3:1)
DUODENAL ULCERS
What is the most common location?
P257
Most are within 2 cm of the pylorus in
the duodenal bulb
DUODENAL ULCERS
What is the classic pain
response to food intake?
P257
Food classically relieves duodenal ulcer pain (Think: Duodenum = Decreased with food)
DUODENAL ULCERS
What is the cause?
P257
Increased production of gastric acid
DUODENAL ULCERS What syndrome must you always think of with a duodenal ulcer? P257
Zollinger-Ellison syndrome
DUODENAL ULCERS
What are the associated risk factors?
P257
Male gender, smoking, aspirin and other
NSAIDs, uremia, Z-E syndrome,
H. pylori, trauma, burn injury
DUODENAL ULCERS
What are the symptoms?
P257
Epigastric pain—burning or aching, usually
several hours after a meal (food, milk,
or antacids initially relieve pain)
Bleeding
Back pain
Nausea, vomiting, and anorexia
↓ appetite
DUODENAL ULCERS
What are the signs?
P258
Tenderness in epigastric area (possibly),
guaiac-positive stool, melena,
hematochezia, hematemesis
DUODENAL ULCERS
What is the differential diagnosis?
P258
Acute abdomen, pancreatitis, cholecystitis,
all causes of UGI bleeding, Z-E
syndrome, gastritis, MI, gastric ulcer,
reflux
DUODENAL ULCERS
How is the diagnosis made?
P258
History, PE, EGD, UGI series
if patient is not actively bleeding
DUODENAL ULCERS
When is surgery indicated
with a bleeding duodenal ulcer?
P258
Most surgeons use: >6 u PRBC
transfusions, >3 u PRBCs needed to
stabilize, or significant rebleed
DUODENAL ULCERS
What EGD finding is
associated with rebleeding?
P258
Visible vessel in the ulcer crater, recent
clot, active oozing
DUODENAL ULCERS
What is the medical treatment?
P258
PPIs (proton pump inhibitors) or H(2)
receptor antagonists—heal ulcers in
4 to 6 weeks in most cases
Treatment for H. pylori
DUODENAL ULCERS
When is surgery indicated?
P258
The acronym “I HOP”: Intractability Hemorrhage (massive or relentless) Obstruction (gastric outlet obstruction) Perforation
DUODENAL ULCERS
How is a bleeding duodenal
ulcer surgically corrected?
P258
Opening of the duodenum through the
pylorus
Oversewing of the bleeding vessel
DUODENAL ULCERS
What artery is involved with
bleeding duodenal ulcers?
P258
Gastroduodenal artery
DUODENAL ULCERS What are the common surgical options for the following conditions: Truncal vagotomy? P258
Pyloroplasty
DUODENAL ULCERS What are the common surgical options for the following conditions: Duodenal perforation? P259
Graham patch (poor candidates, shock, prolonged perforation) Truncal vagotomy and pyloroplasty incorporating ulcer Graham patch and highly selective vagotomy Truncal vagotomy and antrectomy (higher mortality rate, but lowest recurrence rate)
DUODENAL ULCERS
What are the common surgical options for the
following conditions:
Duodenal obstruction resulting from duodenal
ulcer scarring (gastric outlet obstruction)?
P259
Truncal vagotomy, antrectomy, and
gastroduodenostomy (BI or BII)
Truncal vagotomy and drainage procedure
(gastrojejunostomy)
DUODENAL ULCERS What are the common surgical options for the following conditions: Duodenal ulcer intractability? P259
PGV (highly selective vagotomy) Vagotomy and pyloroplasty Vagotomy and antrectomy BI or BII (especially if there is a coexistent pyloric/prepyloric ulcer) but associated with a higher mortality
DUODENAL ULCERS Which ulcer operation has the highest ulcer recurrence rate and the lowest dumping syndrome rate? P259
PGV (proximal gastric vagotomy)
DUODENAL ULCERS Which ulcer operation has the lowest ulcer recurrence rate and the highest dumping syndrome rate? P259
Vagotomy and antrectomy
DUODENAL ULCERS Why must you perform a drainage procedure (pyloroplasty, antrectomy) after a truncal vagotomy? P259
Pylorus will not open after a truncal
vagotomy
DUODENAL ULCERS Which duodenal ulcer operation has the lowest mortality rate? P259
PGV (1/200 mortality), truncal vagotomy and pyloroplasty (1–2/200), vagotomy and antrectomy (1%–2% mortality) Thus, PGV is the operation of choice for intractable duodenal ulcers with the cost of increased risk of ulcer recurrence
DUODENAL ULCERS
What is a “kissing” ulcer?
P260
Two ulcers, each on opposite sides of the
lumen so that they can “kiss”
DUODENAL ULCERS
Why may a duodenal rupture
be initially painless?
P260
Fluid can be sterile, with a nonirritating
pH of 7.0 initially
DUODENAL ULCERS
Why may a perforated duodenal ulcer present as lower quadrant abdominal pain?
P260
Fluid from stomach/bile drains down
paracolic gutters to lower quadrants and
causes localized irritation
GASTRIC ULCERS
In which age group are these
ulcers most common?
P260
40–70 years old (older than the duodenal
ulcer population)
Rare in patients younger than 40 years
GASTRIC ULCERS
How does the incidence in
men compare with that of women?
P260
Men > women