Upper and Lower GI Disorders Flashcards

1
Q

What are the signs and symptoms of constipation?

A
  • Hard, painful stool
  • Poor appetite
  • Irritable
  • Lack of energy
  • Abdominal pain or distension
  • Withholding or straining
  • Diarrhoea
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2
Q

Why can children become constipated?

A
  • Poor diet: insufficient fluids and excessive milk
  • Potty training/ school toilet
  • Intercurrent illness
  • Medications
  • Family history
  • Psychological
  • Organic
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3
Q

How can constipation be treated?

A
  • Parent education
  • Change in diet
  • Reduce aversive factors
  • Laxatives: osmotic laxatives (lactulose), stimulant laxatives (senna, picolax) and isotonic laxatives (movicol)
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4
Q

What are the advantages and disadvantages of using laxatives for constipation?

A
  • Advantages: non invasive and given by parents
  • Disadvantages: non compliance and side effects
  • Empty impacted rectum
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5
Q

How does Crohn’s disease present in children?

A
  • Weight loss
  • Growth failure
  • Abdominal pain
  • Arthritis, mass, diarrhoea and rectal bleeding
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6
Q

How does UC present?

A
  • Diarrhoea
  • Rectal bleeding
  • Abdo pain
  • Tend not to get as many systemic symptoms as Crohn’s
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7
Q

What are you looking for on a history and examination in a child with suspected IBD?

A
  • Intestinal symptoms
  • Extra-intestinal manifestations (joint pain, red, painful, blurry eyes)
  • Exclude infection
  • FH
  • Growth and sexual development
  • Nutritional status
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8
Q

Which investigations would you do in a child with suspected IBD?

A
  • FBC: anaemia, thrombocytosis and raised ESR
  • Biochemistry: stool calprotectin , raised CRP and low albumin
  • Microbiology: no stool pathogens
  • Endoscopy and colonoscopy
  • Mucosal biopsy
  • MRI
  • Barium meal
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9
Q

How is IBD managed in children?

A
  • Induce and maintain remission
  • Correct nutritional deficiencies
  • Maintain normal growth and development
  • Promote quality of life and normal psycho-social development
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10
Q

Name the methods of treatment for IBD

A
  • Medical: anti-inflammatories (5-ASA), immunosuppressants (steroids), thiopurines and biologics (infliximab)
  • Nutritional: immune modulation and nutritional supplementation
  • Surgical
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11
Q

Name the stages of vomiting with retching

A
  • Pre ejection: pallor, nausea and tachycardia
  • Ejection: retch and vomit
  • Post ejection
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12
Q

Name the causes of stimulation of the vomiting centre

A
  • Enteric pathogens
  • Intestinal inflammation
  • Metabolic derangement
  • Infection
  • Head injury
  • Visual stimuli
  • Middle ear stimuli
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13
Q

How does pyloric stenosis present?

A
  • Babies 4-12 weeks
  • Projectile non-bilious vomiting
  • Weight loss
  • Dehydration +/-shock
  • Metabolic alkalosis
  • Hypochloraemia
  • Hypokalaemia
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14
Q

How can pyloric stenosis be managed?

A
  • Fluid resus

- Surgery: Ramstedts pyloromyotomy

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15
Q

What are the causes of bilious vomiting?

A
  • Intestinal obstruction until proved otherwise
  • Intestinal atresia
  • Malrotation +/- volvulus
  • Intussusception
  • Ileus
  • Crohn’s disease with strictures
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16
Q

How can bilious vomiting investigated?

A
  • Abdo XR
  • Contrast meal
  • Surgical opinion re exploratory laparotomy
17
Q

What is the main cause of effortless vomiting?

A

Gastro-oesophageal reflux

18
Q

In which cases does gastro-oesophageal reflux not resolve on its own?

A
  • Cerebral palsy
  • Progressive neurological problems
  • Oesophagial atresia +/- TOF operated
  • Generalised GI motility problem
19
Q

How does reflux present?

A
  • Vomiting
  • Haematemesis
  • Feeding problems
  • Failure to thrive
  • Apnoea
  • Cough
  • Wheeze
  • Chest infections
  • Sandifer’s syndrome
20
Q

How can reflux be assessed?

A
  • History and exam
  • Video fluroscopy
  • Barium swallow
  • pH study
  • Oesophageal inpedance monitoring
  • Endoscopy
21
Q

How can reflux be treated?

A
  • Feeding advice (thickness, texture, feeding position etc.)
  • Nutritional support (calorie supplements, exclusion diet, NG tube and gastrostomy)
  • Medical treatment (feed thickener, prokinetic drugs and acid suppressing drugs)
  • Surgery
22
Q

What are the indications for surgery for reflux?

A

Persisten failure to thrive, aspiration and oesophagitis

23
Q

What is the definition of chronic diarrhoea?

A

4 or more stools a day for more than 4 weeks

24
Q

What are the causes of diarrhoea?

A
  • Toddler diarrhoea
  • IBS
  • Acute infective diarrhoea
  • IBD
  • Food allergy
  • Coeliac disease
  • CF
25
Q

What are the features of osmotic diarrhoea?

A
  • Movement of water into the bowel
  • Usually a feature of malabsorption
  • Generally accompanied by macroscopic and microscopic intestinal injury
  • Clinical remission with removal of causative agent
  • Mechanism of action of lactulose and movicol
26
Q

What are the features of secretory diarrhoea?

A
  • Associated with toxin production from vibrio cholerae and E coli
  • Intestinal fluid secretion predominantly driven by active chlorine secretion via CFTR
27
Q

What are the causes of motility diarrhoea?

A
  • Toddlers diarrhoea
  • IBS
  • Congenital hyperthyroidism
  • Chronic intestinal pseudo-obstruction
28
Q

What are the features of inflammatory diarrhoea?

A
  • Malabsorption due to intestinal damage
  • Secretory effect of cytokines
  • Accelerated transit time in response to inflammation
  • Protein exudate across inflamed epithelium
29
Q

How can diarrhoea be assessed?

A
  • Age at onset
  • Abrupt/gradual onset
  • FH
  • ? Nocturnal defecation
  • Growth and weight gain of child
  • Faeces analysis: appearance and stool culture
30
Q

What are the causes of fat malabsorption?

A
  • Pancreatic disease: CF
  • Chronic liver disease
  • Cholestasis
31
Q

How does coeliac disease present?

A
  • Abdominal bloatedness
  • Diarrhoea
  • Failure to thrive
  • Short stature
  • Constipation
  • Tiredness
  • Dermatitis herpatiformis
32
Q

Which tests can be done for coeliac disease?

A
  • Anti tissue transglutaminase
  • Anti endomysial
  • Anti gliadin
  • IgA
  • Duodenal biopsy
  • Genetic testing: HLA DQ2 and DQ8