Unit Three Flashcards

1
Q

What is cellular respiration

A

Process in which cells consume O2 and produce CO2

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2
Q

What are the three majors stages of cellular respiration

A

Acetyl CoA production, acetyl CoA oxidation, electron transfer and oxidative phosphorylation

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3
Q

Acetyl Co A production generates what

A

ATP, NADH, FADH2

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4
Q

Acetyl co A oxidation generates

A

NADH, FADH2, and one GTP

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5
Q

Oxidative phosphorylation generates a lot of

A

ATP

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6
Q

Glycolysis occurs where

A

Cytoplasm

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7
Q

Citric acid cycle occurs where

A

Mitochondrial matrix

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8
Q

What part of the citric acid cycle occurs in the inner membrane of mitochondria

A

Succinct enough dehydrogenase

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9
Q

Oxidative phosphorylation occurs where

A

Inner mitochondrial matrix

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10
Q

What is the net reaction of conversion of pyruvate to acetyl co a

A

Oxidative decarboxylation of pyruvate, first carbons of glucose to be fully oxidized

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11
Q

Site of conversion of pyruvate to acetyl Co-A

A

Mitochondrial matrix

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12
Q

What catalyze the conversion of pyruvate to acetyl Co A

A

Pyruvate dehydrogenase complex

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13
Q

What is the only reaction with C-C bond formation

A

Citrate synthase

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14
Q

What does citrate synthase do

A

Condensation of acetyl CoA and oxaloacetate

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15
Q

Citrate synthase uses what type of catalysis

A

Acid/Base

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16
Q

What is the good electrophile of oxaloacetate

A

Carbonyl group

17
Q

What is not a good nucleophile of acetyl CoA

A

Methyl

18
Q

What is the rate limiting step of CAC

A

Acetyl Co A to citrate using citrate synthase

19
Q

Activity of citrate synthase depends on

A

Oxaloacetate

20
Q

Citrate synthase goes through conformational change when it binds with

A

Oxaloacetate

21
Q

Open conformation of citrate synthase does not have a binding site for

A

Acetyl CoA

22
Q

Closed conformation for citrate synthase occurs when

A

Binding of OAA which creates binding site for acetyl Co A

23
Q

Citrate to isocitrate is what type of reaction

A

Dehydration/rehydration

24
Q

From citrate to cis-aconitate what occurs

A

Removal of water causing a cis C=C bond

25
Q

Why go from citrate and cis-aconitate

A

Citrate is a tertiary alcohol and is a poor substrate for oxidation

26
Q

Isocitrate is a secondary alcohol and is a good

A

Substrate for oxidation

27
Q

What catalyze the water removal from citrate and subsequent addition to cis-aconitate

A

Iron sulfur center which sensitive to oxidative stress