Unit 8

Question 1

What form are most g- pathogens?

Answer 1

rods

Question 2

What are the 3 g- pathogens that are not rods?

Answer 2

neisseria: diplococci
treponema: spirochete
borrelia: spirochete

Question 3

What endotoxin do g- pathogens have?

Answer 3

LPS in the cell walls

Question 4

What infection by which bacteria poses the greatest risk of endotoxic shock?

Answer 4

Blood infections with shigella, neisseria, and e. coli

Question 5

Can an endotoxin be converted to a toxoid?

Answer 5

No. Only exotoxins can be.

Question 6

Neisseria oxidase test

Answer 6

Positive

Question 7

Neisseria catalase test

Answer 7

Positive

Question 8

Where are neisseria present commensally?

Answer 8

Mucous membranes

Question 9

Bacterial meningitis in newborns is cause by what 3 species?

Answer 9

Listeria
E. coli
Streptococcus agalactiae

Question 10

Bacterial meningitis in individuals over 6 months of age are caused by what 3 species?

Answer 10

Streptococcus pneumoniae
Neisseria meningitides
Haemophilus influenza

Question 11

Can humans be carriers of neisseria meningitides?

Answer 11

Yes, anywhere from days to months

Question 12

How is neisseria meningitides contracted?

Answer 12

Close contact with secretions

Question 13

Neisseria meningitides mechanism of action

Answer 13

engulfed by epithelial cells of the mucosa
penetrate into blood vessels
cross blood-brain barrier
grow in CSF
shed endotoxin which stimulates macs, cytokines lead to vascular hemorrhage and coagulation

Question 14

How is neisseria meningitides diagnosed?

Answer 14

Spinal tap

Question 15

How is neisseria meningitides treated?

Answer 15

Penicillin

chemoprophylaxis for contact

Question 16

Neisseria meningitides virulence factors

Answer 16

huge capsule
LPS endotoxin
pili
adhesins
IgA protease
transferrin binding proteins 
LOS (ligooligosaccharide)