Unit 6 #2 - Genetics Flashcards

1
Q

what did nettie stevens discover

A
1. genes are located on the 
recently discovered CHROMOSOMES 
inside the cell nucleus.
2. in certain insects, the Y 
chromosome is only found in males.

Also, pioneered use of fruit fly as model organism

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2
Q

What is the SRY gene

A

carried by the y chromosome in mammals, causes gonad to develop as a testis (has the coding for the protein responsable to do this). If no SRY gene, then the embryo develops as female, by default.

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3
Q

What genes (3+) are on the y chromosome in humans

A
  1. SRY gene
  2. Gene that gives hairy ears
  3. other genes responsable for sperm+testis development
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4
Q

WHat is the difference between the X and Y chromosome?

A

X chromosome nothing to do with sex and it has many genes.

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5
Q

What is the fruit fly life cycle?

A

embryo, 1st instar larva, 2nd instar larva, 3rd instar larva, prepupa, pupa

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6
Q

What is particular about fruit fly chromosomes

A

4 pairs (2n=8) and they are giant chromosomes (eat a lot, make a lot of saliva and replicate a lot)

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7
Q

In fruit flies, what reabsorbs the nutrients from the old larval body to become parts of the adult fly?

A

Homologous imaginal discs

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8
Q

What is the purpose of a chi square and what needs to be looked at to determine if your suspicion is probable or not

A

Purpose: Quantifying your suspicion and the discrepancy between what you observe and expect

if probability greater than 0.05 = great probability that what you expect will occur/fail to reject null hypothesis

if chi square value calculated is smaller = small discrepancy between between what is observed and expected/fail to reject null hypothesis

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9
Q

When n=2, what is the size of the chromosmes relative to one another

A

2 sets of chromosomes, 1 big, 1 small

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10
Q

Are traits controlled by one gene

A

Often traits are controlled by more than one gene

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11
Q

What did mendel solve? (1866)

A

Darwin’s question about how traits were inherited.
Mendel realised that:
1. each trait is controlled by TWO « factors », one from
the mother and one from the father
2. One factor dominates the other – they do not blend
with each other. (dominate vs recessive)
whereas, darwin thought essence from mother anf father, for example, produced a child…no!

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12
Q

What is chromatin

A

DNA+protein

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13
Q

what are genes made of

A

DNA

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14
Q

Provide an example of self-fertilization and another type of pollination

A

Self-fertilizing (self-pollination): pea flower; produces pollen (male gamete), which is trapped in the flower because it is closed, and ovules (female gamete) so it self-fertilizes
Cross-pollination: remove male organs (so no pollen production) and use brush to collect and fertilizes ovules with the pollen from another plant.

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15
Q

What are pure lines

A

individuals that always give the same phenotype in the offspring

eg pp always gives white flowers for example (its a true-breeding) or PP

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16
Q

What are sport

A

Individual that has the phenotype of a great-grandparent or grandparent

17
Q

Why are genotypes represented with 2 letters eg. PP or Pp…

A

Because everybody has 2 versions of the gene

18
Q

what does P, F1, F2 means

A

Generations: P=parents, F1=child, F2=grandchild….

19
Q

what is a genotype

A

allele combination

20
Q

what is a phenotype

A

physical manifestation of the allele combination

21
Q

what is a gene

A

DNA code for a particular trait

22
Q

What is locus

A

Position of gene on a chromosome

eg. “here (pointing part of chromosome) is the locus for flower-color gene”

23
Q

what is an allele

A

alternative version a a gene

24
Q

Do males and females contribute equally to the appearance of the offspring

A

Yes, doesnt matter if the genetic determinant ie round seeds comes from male or female. Mendel showed this by reciprocal crosses: round seed male to wrinkled seed female and obtained same phenotypes in offspring for round seed female to wrinkle-seed male

25
Q

How did mendel use the scientific method?

A
  1. Selected EITHER: OR traits eg. for garden peas: flower color, seed color, seed texture, pod color…
  2. Used plants that were self-fertilising
  3. Controlled variables
  4. Reciprocal crosses
  5. Independent variable: the parents
  6. Dependent variable: offspring
  7. Quantified results and analysed them mathematically
26
Q

Name dominate and recessive traits in humans with their phenotypes

A

eg: recessive
Albinism: lack of melanin pigmentation
cystic fibrosis: abnormal gland secretion leading to liver degenerations and lung failure
Alkaptonuria: inability to metabolize homogentisic acid (urine black when exposed to light)
Hemophilia: inability blood clots properly
Sickle cell anemia: defective hemoglobin that causes red blood cells to curve and stick togheter

eg dominant traits: (also genetic diseases caused by dominant traits)
Huntington disease: degenerations of nervous system starting in middle age
Hypercholesterolemia: elevated levels of blood cholesterol and risk of heart attack
Polydactyly: extra fingers and toes

27
Q

What do genes cause to be made?

A

Enzymes (chemicals that bring 2 substances together to make a chemical reaction that gives us our appearance) eg gaited horses trot this way because of DMRT3 gene that controls an enzyme that effects nervous system

28
Q

What is Mendel’s first law

A

The Principle of Segregation:
The two alleles for a gene segregate during
gamete formation and are rejoined at random,
one from each parent, during fertilizations. So, gametes have one allele for seed shape since the alleles segregated/”separated” during meiosis I.

29
Q

How can you tell that a plant is true-breeding?

A

Do a test cross with a homozygote recessive, if true-breeding will all give the same phenotype

30
Q

What often causes hereditary diseases

A

Recessive alleles, and more particularly when homozygote recessive. They are versions of genes that stop gene functioning because they mutated. They make no gene product.

31
Q

What does inbreeding cause? eg. pedigree animals

A

increases the likelihood that the offspring will inherit two copies of a recessive allele

32
Q

Name harmless recessive alleles

A
Tongue	rolling T
Widow’s peak	W	
Unattached earlobes	E	
Hitchiker’s thumb	h	
Lex thumb	on	top	when clapping	L	
Mid-digit	hair	M
33
Q

Can genetic disease be cause by dominant genes and not only recessive genes?

A

Yes, usually because they are overly expressed
eg.
Huntington disease : degenerations of nervous system starting in middle age
Hypercholesterolemia: elevated levels of blood cholesterol and risk of heart attack
Polydactyly: extra fingers and toes
Hereditary sensory and autonomic neuropathy HSAN: dont feel pain

34
Q

What is Mendel’s hypothesis on flower colors for garden peas

A

Each parent contributes a factor of inheritance. The combination of these two factors determine the flower colour.

35
Q

What is mendels second law

A

The Principle of Independent Assortment
In a dihybrid cross, the alleles of each gene assort
independently
*Dihybrid cross: AaBb x AaBb