Unit 5 Terms Flashcards

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1
Q

Function of the Nervous System

A

Communication

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2
Q

Sensory Input

A

Monitoring changes using sensory receptors

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3
Q

Integration

A

Process and interpret senses and decide on required action.

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4
Q

Motor Output

A

Cause a response by activating muscles or glands.

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5
Q

Cell

A

The basic unit of a structure and function in the nervous system.

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6
Q

Supporting Cells

A

(Glia). Support, insulation, protection. Cannot transmit impulses. Do not lose their ability to divide.

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7
Q

Neurons

A

Specialized nervous system cell. Conduct electrical impulses that allow cells, tissues, and organs to detect and respond to stimuli. types of neurons.

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8
Q

Nerves

A

Composed of many different neurons bundled together.

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9
Q

Neurons are made up of…

A

-Cell body
-Dendrites
-Axon

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10
Q

Cell Body

A

-Contains nucleus and metabolic center
-Lacks centrioles so it can’t divide

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11
Q

Dendrites

A

Projections or extensions that receive signals from other neurons and carry impulses toward the cell body. Usually highly branched.

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12
Q

Axon

A

A single thin projection from the cell body. Carries impulses away from the cell body towards either other neurons or effectors. Ends in a series of branches with slight enlargements on their ends called axon terminals.

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13
Q

Myelin Sheath

A

Schwann cells in the peripheral nervous system forms a shiny white fatty protein (doesn’t conduct electricity well) wrapped around axons. Remains intact if damaged. Oligodendrocytes form myelin in the central nervous system.

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14
Q

The myelin sheath has three main functions…

A

-protection of nerve fibre
-good insulator
-increase rate of transmission of nerve impulses along the axon. (Gaps between sections of the sheath called nodes of ranvier allow the impulse to jump from node to node.) Allows them to travel much faster than unmyelinated nerves.

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15
Q

Sensory Neurons

A

Gather info from receptors and carry it towards brain or spinal cord. Can be specialized for heat, light, pressure, etc. Cell body is located in clusters called ganglia next to spinal cord. Axons usually terminate at interneurons.

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16
Q

Interneurons

A

Found entirely within CNS. Stimulated by sensory neurons. Information if brought together and a decision is made (sometimes involves brain/spinal cord). Relays the decision to the brain or motor neurons.

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17
Q

Motor Neurons

A

Muscles are glands that respond to stimuli. Effector organs. Carry the impulses from the brain/spinal cord to the effectors that causes a reaction or gland. Cell body is located in spinal cord or brain. Since impulses travel away from cell bodies they have long axons.

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18
Q

Reflex Arc

A

Basic nervous response. Has five basic parts; receptor, sensory neuron, interneuron (in the spinal cord), motor neuron, effector. Withdrawl or protective actions. Brain doesn’t participate. Some interneurons inform the brain so it is still aware. Startle response, blinking, knee jerk, etc.

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19
Q

What happens when the impulse is too important?

A

It is sent to the spinal cord and bypasses the brain causing a faster response.

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20
Q

Polar

A

Opposite charges

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21
Q

Nerve Membrane At Rest…

A

Inner area of the neuron contains more K and is negatively charged, outside area contains Na and is positively charged. This causes polarization and a large potential difference.

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22
Q

Action Potential Initiation and Generation…

A

A stimuli initiates an action potential. Membranes become more permeable and allow a rapid inward movement of sodium ions causing rapid depolarization. If the stimulus is strong enough it transmits a long distance signal called action potential. The huge influx of Na causes other channels to open allowing K ions to leave, repolarization. As the impulse moves forward the original potential is restored behind it.

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23
Q

Threshold value

A

The minimum input needed to initiate an action potential.

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24
Q

Movement of the Impulse along the Neuron…

A

A change in permeability causes a change in the adjoining section as the impulse moves along. In myelinated fibres this occurs only at the nodes of ranvier so it can be up to 4 times faster.

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25
Q

Repolarization must occur…

A

for a neuron to conduct another impulse.

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26
Q

Facts about Action Potentials

A

Neurons have an all or none response. If it’s below the threshold value it causes no impulse, no matter how high above it is it will cause the same impulse unless it’s so strong that it causes a reaction in more neurons. Sedatives block the altering of permeability.

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27
Q

Synaptic Cleft

A

Neurons aren’t directly connected to other neurons, so instead there is a space in between them called the synaptic cleft.

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28
Q

How do impulses get across the synaptic cleft?

A

When an impulse reaches the end of an axon, vesicles release a chemical known as a neurotransmitter into the space via, exocytosis. The neurotransmitter diffuses across the synapse to the membrane of the dendrite off the next neuron.

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29
Q

What does the neurotransmitter do?

A

The chemical alters the permeability of the dendrite’s membrane to sodium ions and a new impulse is initiated.

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30
Q

What happens to the neurotransmitter once it’s finished?

A

Almost as soon as the axon terminal has released the chemical transmitter some of it begins being reabsorbed by the dendrite. Enzymes released by the axon terminal break down the rest. This very fast action prevents the transmitter from continually firing impulses at the dendrite.

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31
Q

What keeps the neuron travelling in only one direction?

A

Only axon terminals release the chemical transmitters and only dendrites are sensitive to them. Therefore, impulses only move from axon terminals to dendrites and not the other way.

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32
Q

Two divisions of the nervous system

A

Central and peripheral.

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33
Q

Central Nervous System

A

Made up of brain and spinal cord and the interneurons carrying information in and out. Integrating and command centers. Interpret sensory information based on past experience and current conditions. Like a control panel that receives input signals, analyses them, and send out instructions. Stores information for future use.

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34
Q

Peripheral Nervous System

A

Made up of nerves that carry information between organs in the body and the central nervous system (sensory and motor neurons). Communication lines.

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35
Q

The Brain

A

Contains over 1 billion neurons. From the superior view we see two large hemispheres. Three protective meninges cover the entire brain. Between the second and third layers there is cerebrospinal fluid that is further protection. This fluid is secreted by clusters of capillaries. The fluid also functions in nutrient distribution, waste removal, movements of hormones, movement of white blood cells. Divided into forebrain, midbrain, and hindbrain.

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36
Q

Hindbrain

A

Made up of the cerebellum, the pons, and medulla oblongata.

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37
Q

Medulla Oblongata

A

Nerve impulses controlling some of the vital processes that are involuntary such as breathing, heartbeat, swallowing, blood pressure occur here. Damage equals coma or death.

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38
Q

Pons (bridge)

A

acts as a relay station passing information between cerebellum and the cerebrum. A pathway connecting the various parts of the brain with each other. Important in breathing.

39
Q

Cerebellum

A

Coordinates muscle actions, balance, posture, etc. Impaired by alcohol. Muscle instructions from the nerves and cerebrum enter and are coordinated so we can maintain balance. Important in learning and remembering motor responses.

40
Q

Midbrain

A

Relays impulses between forebrain and hindbrain. Relays impulses between forebrain and eyes/ears.

41
Q

Brain Stem

A

made up of the medulla, pons, and midbrain. All information must pass through on the way to higher brain regions, it serves as a filter.

42
Q

Forebrain

A

Largest part of the brain. Cerebrum takes up most of it. other parts are the thalamus and hypothalamus.

43
Q

Cerebrum

A

Divided into left and right hemispheres. Each consists of many creases. Deepest crease creates the two hemispheres, it extends down to the corpus callosum where nerve bundles cross over from one hemisphere to the other allowing communication between left and right. Other deep creases divide each hemisphere into four segments (frontal, parietal, occipital, and temporal). Consists of three basic regions (cerebral cortex, white matter, basal nuclei.)

44
Q

Cerebral Cortex

A

Non-myelinated. The gray matter. Speech, memory, logic, emotional response, interpretation of voluntary movement, interpretation of sensation, consciousness.

45
Q

White Matter

A

fibre tracts (connections)

46
Q

Basal Nuceli

A

patches of gray matter that helps regulate the stopping of voluntary motor actions.

47
Q

Thalamus

A

Below the cerebrum. In and area where sensory messages pass through and these enable us to be aware of pressure, pain, or temperature extremes.

48
Q

Hypothalamus

A

Mostly functions in the endocrine system. Below the thalamus. Regulates the pituitary gland. Controls water and salt concentration in the blood. Regulates body temperatures, blood pressure, thirst, sex drive, fight or flight responses, and helps experience emotions. Maintains sleep and hunger and is our biological clock.

49
Q

Spinal Cord

A

Other major coordinating center of CNS. Two way pathway to and from brain. Major reflex center, surrounded by meninges. 31 pairs of spinal nerves arise from the cord and serve as a link between CNS and brain. Damage to grey matter can result in flaccid paralysis (no movement). Damage to white matter can result in spastic paralysis (involuntary spastic movements).

50
Q

Structure of a Nerve

A

A nerve is a bundle of fibres on the outside of the CNS. Classified according to which way they transmit impulses. Sensory nerves carry impulses to CNS, motor nerves carry them away. Mixed do both.

51
Q

The Somatic Nerves

A

Nerves that the body has conscious control over. Carries voluntary actions back and forth between organs. Skeletal, muscles, skin.

52
Q

The Autonomic Nerves

A

Actions/responses can’t be voluntarily controlled. Regulate conditions in the internal environment. Smooth muscle, cardiac muscle, organs, breathing rate, stomach secretions. Made up of two sets of neurons with opposing effects, sympathetic and parasympathetic.

53
Q

Sympathetic

A

Nerves come from thoracic and lumbar vertebrae. Involves all internal adjustments that prepare the body for action or increased levels of stress.

54
Q

Parasympathetic

A

Leave brain directly or from cervical or caudal sections of spinal cord. Carry impulses that return the body to normal after a period of high stress. Allows us to conserve energy.

55
Q

Functions of Sympathetic

A

Dilates pupil, inhibits salivation, relaxes bronchi, accelerates heart, inhibits digestive activity, stimulates glucose release, secretion of adrenaline, relaxes bladder, contracts rectum.

56
Q

Functions of Parasympathetic

A

Constricts pupil, stimulates salivation, inhibits heart, constricts bronchi, stimulates digestive activity, stimulates gallbladder, contracts bladder, relaxes rectum.

57
Q

What is an MRI?

A

A type of anatomical imaging based on the behaviour of neutrons and protons. Provides detailed images of soft tissue in any plane.

58
Q

How Does an MRI Work?

A
  1. The normal behaviour of neutrons, electrons, and protons causes a small, magnetic field around the atom. Our atoms are constantly changing and moving meaning the magnetic field is not aligned.
  2. Radio waves are introduced and the hydrogen atoms absorb the energy which alters the alignment. Once the radio waves are stopped the H return to normal alignment and release the energy they absorbed, this energy is read.
    An injectable contrast can be used.
59
Q

What to Expect during MRI?

A

Fast for 6 hours previous. Remove anything magnetic, lie completely still. Can be very loud.

60
Q

Functional Magnetic Resonance Imaging

A

Used for measuring and mapping brain activity. Blood flow is sensitive to changes in neural activity, so fMRI creates images by detecting changes in blood flow. Oxygenated and deoxygenated blood is affected differently.

61
Q

Endocrine System

A

Composed of glands and function as a communication/control system. Relies on chemical messengers, but uses hormones instead of neurotransmitters. Slower than nervous system. No electrical impulses.

62
Q

Hormones

A

Chemical messengers that affect target cells and tissues to produce a specific response. They are produced within cells and move through the circulatory system.

63
Q

Target Cells

A

Have receptors or molecules that combine with certain hormones. These receptors can be on the surface or inside depending on the hormone.

64
Q

Jobs of Hormones

A
  1. synthesis of proteins/regulatory molecules (ie. enzymes) in the cell
  2. activation or inactivation of enzymes
  3. stimulation of mitosis
  4. promotion of secretory activity
65
Q

Steroid Hormones

A

> direct gene activation (leading to protein synthesis)
soluble in lipids (therefore can diffuse through plasma membranes)
bind receptor inside cell in nucleus
hormone-receptor complex attaches to DNA in nucleus and signals mRNA transcription
– ex: estrogen and testosterone

66
Q

Amino Acid Hormones

A

> composed of amino acids
second messenger system
hormone binds to receptors on membrane of target cell (not lipid soluble)-1st messenger
receptor activates enzyme inside cell which starts a biochemical pathway (cascade)
final molecule in pathway activates a protein/enzyme to carry out the response-2nd messenger
– ex: insulin and growth hormones

67
Q

Why do Endocrine Glands Release Hormones?

A
  • Negative Feedback Mechanisms
  • how the endocrine system controls/regulates itself
  • how much hormone is present in the blood determines whether more or less of the
    hormone is produced
  • a stimulus triggers hormone secretion; then rising hormone levels inhibit further
    hormone release…then hormone levels drop in the blood
68
Q

Endocrine

A

Ductless. Endocrine glands secrete hormones directly into the blood or lymph.
* Glands have blood vessels running through them so that hormones do not find it
difficult to enter the circulatory system.
* All the ductless glands, whose hormones remain inside a body, make up an
endocrine system.

69
Q

Exocrine

A

exocrine glands utilize ducts or tubes to transport their secretions to
specific areas of the body, which could include outside surfaces or internal body cavities
* Examples are sweat glands, salivary glands and tear glands.
* They secrete such substances as sweat, milk, digestive enzymes and other materials

70
Q

Hypothalamus

A

sensitive to various body
conditions, including chemical concentrations, and can
transmit neural or chemical signals to the pituitary and
other glands to control these.
* regulates other endocrine glands
* synthesizes 2 hormones to be released by the pituitary
gland

71
Q

Antidiuretic Hormone (ADH or Vassopressin)

A

o acts as an antidiuretic.
* promotes retention of water by kidneys; thus, inhibiting urine production
* It increases the permeability of the kidney tubules, causing the kidneys to reabsorb
much of the water originally removed from the blood.
* increases blood pressure
* causes contraction of arterial walls
* increases blood volume
* Occasionally, the pituitary may not release very much of this hormone.
* This action would lead to body dehydration and excessive thirst.
* Even if a pituitary is functioning properly under ordinary circumstances, consumption of alcohol/
caffeine will begin suppressing the production of ADH.
* This is what increases the frequency of urination when a person drinks alcohol or caffeine

72
Q

Pituitary Gland

A

About the size of a pea, the structure of this gland has two functional parts: an anterior lobe and a
posterior lobe.
* The posterior lobe developed as an apparent extension of a portion of the hypothalamus.
* The anterior lobe developed from a different kind of embryonic tissue and is considered as a true
endocrine gland (while the posterior lobe is not generally considered as such).
* The release of these hormones into the blood is controlled mainly by the hypothalamus
* Most of the pituitary hormones influence other glands, causing them to produce and release secretions
* For this reason, the pituitary gland is often called the “master gland”
* Anterior Lobe
> synthesizes and secretes HGH, FSH, LH, Prolactin, TSH, and ACTH
* Posterior Lobe
> secretes oxytocin and ADH

73
Q

Thyroid Stimulating Hormone (TSH)

A
  • influences the growth and activity of the thyroid gland
74
Q

ACTH (Adrenocorticotropic hormone)

A

regulates the endocrine activity of the cortex of the adrenal gland.

75
Q

Human Growth Hormone (HGH)

A
  • stimulates growth (indirectly controls skeletal muscle and long bone development) and metabolic
    functions.
  • stimulates protein synthesis and cell growth and division
  • causes fat to be broken down to be used for energy (instead of glucose)
  • Imbalances:
  • An excess of this hormone during childhood can lead to a pituitary giant
    (sometimes called gigantism), with individuals ranging in height from 8-9 feet
    (body proportions are fairly normal)
  • Excess HGH in adults produces acromegaly, symptoms of which include
    excessive thickening of bone tissue, leading to abnormal growth of head,
    hands and feet.
  • A deficiency of the hormone during childhood results in pituitary
    dwarfism, with individuals being about 4 feet tall (body proportions are
    fairly normal)
76
Q

Gonadotrophic hormones (FSH and LH)

A
  • Act upon and regulate the hormonal activity of the sex organs (gonads) of females and males.
  • In males, FSH (Follicle-stimulating hormone) stimulates the formation of sperm producing
    tubules in testes.
  • In females, FSH promotes follicle development in ovaries (for egg development); as the follicle
    matures it also produces estrogen
  • Estrogen is responsible for secondary female sex characteristics and also affects female
    reproductive cycles.
  • In females, Luteinizing hormone (LH) induces ovulation, or release of an egg, from the ovary; it
    also causes the ruptured follicle to make estrogen and progesterone
  • In males, LH acts upon cells in the testes causing them to release other testosterone
  • Imbalances:
  • a deficiency of FSH and/or LH in both males and females leads to sterility
  • an excess may lead to increased fertility and multiple births
77
Q

Prolactin

A
  • In humans it is produced during and after pregnancy.
  • It stimulates the development of mammary glands and milk production in females; function not
    known in males
78
Q

Thyroid Gland

A

located at base of the throat (inferior to the Adam’s apple)
* makes two hormones: thyroid hormone and calcitonin

79
Q

Calcitonin

A
  • lowers blood calcium
  • signals bones to absorb calcium and
    kidneys to increase calcium secretion
80
Q

Thyroid Hormone (Thyroxine and Triiodothyronine)

A

Is an iodine-containing hormone which controls the rate of body metabolism.
> controls the rate of cellular respiration
* every cell needs energy, so every cell is a target for this hormone
* Often, this hormone may be undersecreted or oversecreted, leading to medical complications.

81
Q

Hypothyroidism

A

Undersecretions of thyroxine.
* This may be caused by iodine shortages in the environment and diet (leads to
Goiters)
* If lack of stimulation by TSH in childhood, the result is Cretinism, where an
individual remains very short, is the resulting abnormality/ disease.
* Individuals are not only small physically, but are poorly developed mentally (a
(difference from pituitary dwarfism).
* If lack of stimulation by TSH in adulthood, the result is Myxedema, whish is
characterizes by physical and mental sluggishness

82
Q

Hyperthyroidism

A
  • Overproduction of thyroxine.
  • Individuals may be hyperactive or irritable, unable to sleep and show
    such body symptoms as
    trembling, rapid heart beat, nervousness, sweating, weight losses and
    protruding eyes. May lead to Goiters
    > example: Grave’s Disease
  • can be treated surgically (removal of the tumor or part of thyroid
    gland) or chemically (thyroid blocking drugs or radioactive iodine)
83
Q

Parathyroid Glands

A

Located on the posterior side of the thyroid gland. * secretes Parathyroid hormone
* regulator of concentration of calcium ions in the blood.
* The hormone causes bone cells destruction to release calcium
into surrounding blood vessels and kidneys and intestines to
increase reabsorption of calcium.
* Calcium ions are used in bone formation and are also
particularly important in muscle contractions
* Low calcium levels can lead to muscle twitches, convulsions and
death because neurons become overactive and deliver impulses to
muscles so rapidly that uncontrollable spasms result
* A reduced amount of calcium in the diet causes parathyroid
hormone to remove more of the mineral from the bones.
* This can cause the bones to be weak, deformed and prone to
breaking easily

84
Q

Thymus Gland

A

upper thoracic cavity, posterior to the sternum
* A two-lobed gland, which is prominent in the early years but
becomes reduced in size in adulthood
* this gland is important in the early development years when the
body is first setting up an immune system
* Produces Thymosin
* stimulates T-cell development

85
Q

Testes

A
  • When testes are stimulated by the LH from the pituitary
    gland, they produce and release a number of hormones called
    androgens of which testosterone is the most important.
  • This hormone leads to a further development of the male
    gonads and to a development of the secondary male sex
    characteristics
86
Q

Ovaries

A

Estrogens and progesterones are
two types of steroid hormones produced by the
ovaries when they are influenced by the FSH and
LH from the pituitary gland.
* Estrogens lead to the development
of secondary sexual characteristics of
females.
* These hormones also promote cyclic changes in
the uterine lining (menstrual cycle)
* Estrogens are released by the follicles in which
eggs develop. Progesterone is released when the
follicle ruptures (corpus luteum)

87
Q

Pancreatic Islets

A
  • There are isolated clusters of cells throughout the
    pancreas, called islats of Langerhans, which function as
    an endocrine gland to act as fuel sensors
  • normal blood glucose = 80-120 mg/mL
  • Two kinds of cells make up the islets of Langerhans:
    Alpha and Beta Cells
88
Q

Beta Cells

A

> produces insulin
released when blood glucose is high
acts of body cells and increases their ability to
transport glucose across plasma membranes into cells
to be used in cellular respiration or stored as glycogen

89
Q

Alpha Cells

A

> produces glucagon (antagonist of insulin)
released when blood glucose is low
stimulates a particular enzyme in the liver to convert
glycogen, carbohydrates and fats into glucose, which
enters the blood stream to increase blood glucose

90
Q

Diabetes Mellitus

A

the condition commonly resulting from a shortage of insulin or not properly using
insulin, is treated with injections of insulin from animal extracts.
> Type 1: early onset (by age 20): body cannot make insulin
> Type 2: 70-80% of people; onset over the age of 40; cells become insensitive to insulin (insulin
resistance)

91
Q

Adrenal Glands

A
  • located on the top of each kidney
  • a darker central area or adrenal medulla is surrounded by a lighter outer part called the
    adrenal cortex
    > these two parts have different functions
92
Q

Adrenal Cortex

A
  • produces many secretions which are steroid in nature (corticosteroids)
  • Mineralocorticoids (Aldosterone)
    > increases kidney reabsorption of sodium and potassium
    > water is reabsorbed as well
  • Glucocorticoids (cortisone and cortisol)
    > helps cells convert fats and amino acids into glucose
93
Q

Adrenal Medulla

A

> the “emergency gland”
it triggers adrenaline (epinephrine) and noradrenaline (norepinephrine)
both of these hormones induce changes designed to prepare the body for some type of action
stimulated by the sympathetic nervous system
the liver converts glycogen into glucose and releases it into the blood (increase blood sugar
levels)
breathing rates (and heart rate) increase and blood vessels constrict which sends more blood to the
heart and muscles where it is needed more