Unit 5 Cytotoxic Drug Reconstitution Flashcards
What is cytotoxic drug
chemical substances that damage cells. These drugs are used to treat cancer and work by interfering with the replication and growth of
cells
Activities with exposure risk
PREPARATION
- handling and manipulating these drugs, which can lead to exposure through splashes, inhalation, or skin contact
ADMINISTRATION
- handling cytotoxic drugs during their administration to patients
CLEANING
- management of spills or leaks of cytotoxic drugs
Cause of accidental exposure
- Insufficient Understanding of
Safe Handling Procedures
( Not knowing the proper procedures for handling cytotoxic drugs can lead to accidental exposure ) - improper use of PPE
- accidental spills or leaks
- contaminated surfaces
Effects of exposure
- cell damage
- DNA mutation
- organ dysfunction
- immune system suppression
Safe working practices
- education and training
- control of working environment
- adoption of safe working procedures
Safe handling legislation
Work Health and Safety Act 2011, the Work Health and Safety Regulation
2011, and the Health Act 1937 are key pieces of legislation that define the
safety requirements for handling hazardous substances, including cytotoxic drugs. The Health Regulation 1996
Cytotoxic drug preparation
- Education
Appropriate personnel and qualified - Clean room
Maintain safe work environment - Procedure
Implementing safe work procedures, including following established standard operating procedures (SOP) - Validation
Performing regular assessments to ensure safe practices are maintained
Staff responsibility
- quality
- training
- supervision
- safety
- documentation
- compliance
- communication
Cytotoxic drug contents
- storage condition
- expiry date
- preparation instruction
- administration guideline
- information
- storage requirement
- label and packaging
Safety steps CDR reconstitution
- Wear proper PPE before enter hood
- Ensure Laminar flow hood function
- Follow strict aseptic technique
- Disinfect hood surfaces before and after use
- Clean label containers and equipment inside hood
- Use single use items
- Keep work area organized
- Establish no entry zone
- Clean and maintain hood
Preparation of cytotoxic drug in clean room
- Cleanliness standard
Minimise particle and microorganism contamination - Air filtration and pressure control
Hepa filter and pressure - controlled with positive pressure to prevent the
entry of contaminated air - Personnel protection
Gowns, gloves and masks to minimise contamination
Procedures entry into clean room
BEFORE ENTER
- remove accessories, makeup and wash hands and dry
INSIDE CHANGING ROOM
- wear shoe cover, head cover, mask
ENTRY INTO GRADE C OR GRADE D CLEAN ROOM
- non sterile garment, sterile non powdered gloves and sterile latex chemo gloves
ENTRY GRADE B CLEAN ROOM
- sterile non powdered gloves, sterile garments, enter gkwning room without touching handle, wear hood, jumpsuit, booties, throw away first gloves and wear sterile latex chemo gloves
Cleaning CDR safety cabinet
- Work surface
- walls and floors
- equipments
- waste disposal
Management of cytotoxic drug reconstitution isolater
- Use alcohol 70 % and non woven pad
- Spray on non woven pad
- Swab air lock area
- Swab preparation tray
- Swab preparation drugs
- All drug and close devices put on tray
- Put worksheet and preparation into air lock
- Preparation cytotoxic drug
- Second swabbing in sterile room
Waste management of cytotoxic drugs reconstitution
Specific protocols must be followed for safe disposal of cytotoxic waste,
with the aim of protecting personnel and the environment. Protocols
include the use of special containers for cytotoxic waste, proper labelling of the waste and the safe disposal of contaminated materials
